Abstract：
:T and innate lymphoid cells (ILCs) share some aspects of their developmental programs. However, although Notch signaling is strictly required for T cell development, it is dispensable for fetal ILC development. Constitutive activation of Notch signaling, at the common lymphoid progenitor stage, drives T cell development and abrogates ILC development by preventing Id2 expression. By combining single-cell transcriptomics and clonal culture strategies, we characterize two heterogeneous α4β7-expressing lymphoid progenitor compartments. αLP1 (Flt3(+)) still retains T cell potential and comprises the global ILC progenitor, while αLP2 (Flt3(-)) consists of ILC precursors that are primed toward the different ILC lineages. Only a subset of αLP2 precursors is sensitive to Notch signaling required for their proliferation. Our study identifies, in a refined manner, the diversity of transitional stages of ILC development, their transcriptional signatures, and their differential dependence on Notch signaling.
journal_name
Cell Repjournal_title
Cell reportsauthors
Chea S,Schmutz S,Berthault C,Perchet T,Petit M,Burlen-Defranoux O,Goldrath AW,Rodewald HR,Cumano A,Golub Rdoi
10.1016/j.celrep.2016.01.015subject
Has Abstractpub_date
2016-02-16 00:00:00pages
1500-1516issue
6issn
2211-1247pii
S2211-1247(16)00036-Xjournal_volume
14pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Folates are cofactors for biosynthetic enzymes in all eukaryotic and prokaryotic cells. Animals cannot synthesize folate and must acquire it from their diet or microbiota. Previously, we showed that inhibiting E. coli folate synthesis increases C. elegans lifespan. Here, we show that restriction or supplementation of ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.01.051
更新日期：2016-02-23 00:00:00
abstract：:Evidence suggests that Polycomb (Pc) is present at chromatin loop anchors in Drosophila. Pc is recruited to DNA through interactions with the GAGA binding factors GAF and Pipsqueak (Psq). Using HiChIP in Drosophila cells, we find that the psq gene, which has diverse roles in development and tumorigenesis, encodes dist...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.096
更新日期：2019-09-03 00:00:00
abstract：:53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other proteins, initial recruitment of 53BP1 to sites of DNA damage de...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.10.074
更新日期：2015-12-15 00:00:00
abstract：:Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide protection from future encounters, and their generation is the goal of many vaccin...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.064
更新日期：2019-08-20 00:00:00
abstract：:Protein-coding genes undergo a wide array of regulatory interactions with factors that engage non-coding regions. Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding a major role in gene regulation. Here, we explore Piwi-interacting (pi)RNA-mediated transgene silencing...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.009
更新日期：2018-02-27 00:00:00
abstract：:We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirm...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108448
更新日期：2020-12-08 00:00:00
abstract：:Epigenomic mechanisms direct distinct gene expression programs for different cell types. Various in vivo tissues have been subjected to epigenomic analysis; however, these studies have been limited by cellular heterogeneity, resulting in composite gene expression and epigenomic profiles. Here, we introduce "NuTRAP," a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.12.087
更新日期：2017-01-24 00:00:00
abstract：:The molecular basis of higher regenerative capacity of cold-blooded animals comparing to warm-blooded ones is poorly understood. Although this difference in regenerative capacities is commonly thought to be a result of restructuring of the same regulatory gene network, we hypothesized that it may be due to loss of som...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.09.038
更新日期：2019-10-22 00:00:00
abstract：:Complex febrile seizures (FSs) lead to a high risk of intractable temporal lobe epilepsy during adulthood, yet the pathological process of complex FSs is largely unknown. Here, we demonstrate that activated microglia extensively associated with glutamatergic neuronal soma displace surrounding GABAergic presynapses in ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108346
更新日期：2020-11-03 00:00:00
abstract：:Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. Liver-stage infection is suppressed by thes...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.03.018
更新日期：2014-04-24 00:00:00
abstract：:Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human (HeLa) cells, and ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.07.024
更新日期：2013-08-29 00:00:00
abstract：:The mechanisms by which p53 suppresses tumor growth remain ill defined. In this issue of Cell Reports, Timofeev et al. (2013) and Valente et al. (2013) reveal context-dependent contributions of p53-dependent apoptosis to its tumor-suppressive function. ...
journal_title：Cell reports
pub_type： 评论,杂志文章
doi：10.1016/j.celrep.2013.05.011
更新日期：2013-05-30 00:00:00
abstract：:Understanding how antibiotics impact bacterial metabolism may provide insight into their mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we profiled the metabolome of Escherichia coli after treatment with three different classes of bactericidal antibiotics (?-lactams, aminoglycosides, ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.09.059
更新日期：2015-11-03 00:00:00
abstract：:CRISPR-Cas13a enzymes are RNA-guided, RNA-activated RNases. Their properties have been exploited as powerful tools for RNA detection, RNA imaging, and RNA regulation. However, the relationship between target RNA binding and HEPN (higher eukaryotes and prokaryotes nucleotide binding) domain nuclease activation is poorl...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.105
更新日期：2018-07-24 00:00:00
abstract：:Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.123
更新日期：2018-05-08 00:00:00
abstract：:Trithorax proteins and long-intergenic noncoding RNAs are critical regulators of embryonic stem cell pluripotency; however, how they cooperatively regulate germ layer mesoderm specification remains elusive. We report here that HoxBlinc RNA first specifies Flk1(+) mesoderm and then promotes hematopoietic differentiatio...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.12.007
更新日期：2016-01-05 00:00:00
abstract：:DNA polymerase ζ (Polζ) is specialized for the extension step of translesion DNA synthesis (TLS). Despite its central role in maintaining genome integrity, little is known about its overall architecture. Initially identified as a heterodimer of the catalytic subunit Rev3 and the accessory subunit Rev7, yeast Polζ has ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.08.046
更新日期：2013-10-17 00:00:00
abstract：:Long noncoding RNAs (lncRNAs) are pervasively expressed in mammals, although their functions during development remain poorly understood. In this issue of Cell Reports, Delpretti et al. and Li et al. suggest essential roles for lncRNAs in coordinating Hox gene expression. ...
journal_title：Cell reports
pub_type： 评论,杂志文章
doi：10.1016/j.celrep.2013.09.033
更新日期：2013-10-17 00:00:00
abstract：:In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated at Ser139 to promote DSB repair. Here we show that H2AX is rapidly stabilized in response to DSBs to efficiently generate γH2AX foci. This mechanism operated even in quiescent cells that barely expressed H2AX. H2AX stabilization resulted fr...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.11.054
更新日期：2015-12-29 00:00:00
abstract：:Cockayne syndrome (CS) is a severe neurodevelopmental disorder characterized by growth abnormalities, premature aging, and photosensitivity. Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we attempted to bypass its function by expressing downstream target genes. Intrigui...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.051
更新日期：2016-03-22 00:00:00
abstract：:Shoot formation is accompanied by active cell proliferation and expansion, requiring that metabolic state adapts to developmental control. Despite the importance of such metabolic reprogramming, it remains unclear how development and metabolism are integrated. Here, we show that disruption of ANGUSTIFOLIA3 orthologs (...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108127
更新日期：2020-09-08 00:00:00
abstract：:A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study the origin of novelties because mammals preserve stages in the...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.12.052
更新日期：2015-02-03 00:00:00
abstract：:The endoplasmic reticulum (ER) unfolded protein response (UPR(er)) pathway plays an important role in helping pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPR(er) gene expression appears in rodent and human type 2 diabetic (T2D) islets, the underlyin...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.03.079
更新日期：2016-05-03 00:00:00
abstract：:How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.04.078
更新日期：2018-05-22 00:00:00
abstract：:KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood. We report that mutant KRAS regulates intracellular fatty acid metabolism through Acyl-coen...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.07.009
更新日期：2016-08-09 00:00:00
abstract：:Remyelination is a multistep regenerative process that results in the reformation of myelin sheaths around demyelinated axons and is a critical therapeutic target. Here we show that immediate access to a running wheel following toxin-induced demyelination in mice enhances oligodendrogenesis, the rate of remyelination,...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.08.060
更新日期：2018-09-18 00:00:00
abstract：:Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains fail...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.01.052
更新日期：2019-02-05 00:00:00
abstract：:Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range signaling from synapses in dendrites to the nucleus in the cell soma. Here, we ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.005
更新日期：2019-03-26 00:00:00
abstract：:A better understanding of the impact of antibiotics on bacteria is required to increase the efficiency of antibiotic treatments and to slow the emergence of resistance. Using Escherichia coli, we examined how bacteria exposed to sublethal concentrations of ampicillin adjust gene expression patterns and metabolism to s...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.09.001
更新日期：2016-09-27 00:00:00
abstract：:Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely understood. We profiled microglia of a discrete developing CNS region, the murine ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.062
更新日期：2019-05-14 00:00:00
