Abstract:
:A better understanding of the impact of antibiotics on bacteria is required to increase the efficiency of antibiotic treatments and to slow the emergence of resistance. Using Escherichia coli, we examined how bacteria exposed to sublethal concentrations of ampicillin adjust gene expression patterns and metabolism to simultaneously deal with the antibiotic-induced damage and maintain rapid growth. We found that the treated cells increased energy production, as well as translation and macromolecular repair and protection. These responses are adaptive, because they confer increased survival not only to lethal ampicillin treatment but also to non-antibiotic lethal stresses. This robustness is modulated by nutrient availability. Because different antibiotics and other stressors induce the same set of responses, we propose that it constitutes a general core hormetic stress response. It is plausible that this response plays an important role in the robustness of bacteria exposed to antibiotic treatments and constant environmental fluctuations in natural environments.
journal_name
Cell Repjournal_title
Cell reportsauthors
Mathieu A,Fleurier S,Frénoy A,Dairou J,Bredeche MF,Sanchez-Vizuete P,Song X,Matic Idoi
10.1016/j.celrep.2016.09.001subject
Has Abstractpub_date
2016-09-27 00:00:00pages
46-57issue
1issn
2211-1247pii
S2211-1247(16)31205-0journal_volume
17pub_type
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