Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics.

Abstract:

:A better understanding of the impact of antibiotics on bacteria is required to increase the efficiency of antibiotic treatments and to slow the emergence of resistance. Using Escherichia coli, we examined how bacteria exposed to sublethal concentrations of ampicillin adjust gene expression patterns and metabolism to simultaneously deal with the antibiotic-induced damage and maintain rapid growth. We found that the treated cells increased energy production, as well as translation and macromolecular repair and protection. These responses are adaptive, because they confer increased survival not only to lethal ampicillin treatment but also to non-antibiotic lethal stresses. This robustness is modulated by nutrient availability. Because different antibiotics and other stressors induce the same set of responses, we propose that it constitutes a general core hormetic stress response. It is plausible that this response plays an important role in the robustness of bacteria exposed to antibiotic treatments and constant environmental fluctuations in natural environments.

journal_name

Cell Rep

journal_title

Cell reports

authors

Mathieu A,Fleurier S,Frénoy A,Dairou J,Bredeche MF,Sanchez-Vizuete P,Song X,Matic I

doi

10.1016/j.celrep.2016.09.001

subject

Has Abstract

pub_date

2016-09-27 00:00:00

pages

46-57

issue

1

issn

2211-1247

pii

S2211-1247(16)31205-0

journal_volume

17

pub_type

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