Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma.

abstract：:During cell division, the molecular motor Eg5 crosslinks overlapping antiparallel microtubules and pushes them apart to separate mitotic spindle poles. Dynein has been proposed as a direct antagonist of Eg5 at the spindle equator, pulling on antiparallel microtubules and favoring spindle collapse. Some of the experime...

journal_title：Cell reports

authors： Florian S,Mayer TU

更新日期：2012-05-31 00:00:00

abstract：:A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study the origin of novelties because mammals preserve stages in the...

journal_title：Cell reports

authors： Lynch VJ,Nnamani MC,Kapusta A,Brayer K,Plaza SL,Mazur EC,Emera D,Sheikh SZ,Grützner F,Bauersachs S,Graf A,Young SL,Lieb JD,DeMayo FJ,Feschotte C,Wagner GP

更新日期：2015-02-03 00:00:00

abstract：:Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and neurodegeneration in mice. Transcriptional analysis of endophilin-A mutant mi...

journal_title：Cell reports

authors： Murdoch JD,Rostosky CM,Gowrisankaran S,Arora AS,Soukup SF,Vidal R,Capece V,Freytag S,Fischer A,Verstreken P,Bonn S,Raimundo N,Milosevic I

更新日期：2016-10-18 00:00:00

abstract：:Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...

journal_title：Cell reports

authors： Moore AR,Ran L,Guan Y,Sher JJ,Hitchman TD,Zhang JQ,Hwang C,Walzak EG,Shoushtari AN,Monette S,Murali R,Wiesner T,Griewank KG,Chi P,Chen Y

更新日期：2018-02-27 00:00:00

abstract：:The transcriptional coactivators PGC-1α and PGC-1β are widely thought to be required for mitochondrial biogenesis and fiber typing in skeletal muscle. Here, we show that mice lacking both PGC-1s in myocytes do indeed have profoundly deficient mitochondrial respiration but, surprisingly, have preserved mitochondrial co...

journal_title：Cell reports

authors： Rowe GC,Patten IS,Zsengeller ZK,El-Khoury R,Okutsu M,Bampoh S,Koulisis N,Farrell C,Hirshman MF,Yan Z,Goodyear LJ,Rustin P,Arany Z

更新日期：2013-05-30 00:00:00

abstract：:Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam(+)UEA1(-)Ly-51(+)PLET1(+)MHC class II(hi), which comprises <0.5% of adult TECs, contains bipotent ...

journal_title：Cell reports

authors： Ulyanchenko S,O'Neill KE,Medley T,Farley AM,Vaidya HJ,Cook AM,Blair NF,Blackburn CC

更新日期：2016-03-29 00:00:00

abstract：:Intracellular transport and homeostasis of the endomembrane system in eukaryotic cells depend on the formation and fusion of vesicular carriers. Coat protein complex (COP) II vesicles export newly synthesized secretory proteins from the endoplasmic reticulum (ER), whereas COPI vesicles facilitate traffic from the Golg...

journal_title：Cell reports

authors： Adolf F,Rhiel M,Hessling B,Gao Q,Hellwig A,Béthune J,Wieland FT

更新日期：2019-01-02 00:00:00

abstract：:Recent rapid progress in the field of mechanobiology has been driven by novel emerging tools and methodologies and growing interest from different scientific disciplines. Specific progress has been made toward understanding how cell mechanics is linked to intracellular signaling and the regulation of gene expression i...

journal_title：Cell reports

authors： Cox CD,Bavi N,Martinac B

更新日期：2019-10-01 00:00:00

abstract：:The Drosophila pharyngeal taste organs are poorly characterized despite their location at important sites for monitoring food quality. Functional analysis of pharyngeal neurons has been hindered by the paucity of molecular tools to manipulate them, as well as their relative inaccessibility for neurophysiological inves...

journal_title：Cell reports

authors： Chen YD,Dahanukar A

更新日期：2017-12-05 00:00:00

abstract：:Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to severe ETC dysfunction when inactivated, we performed a genome-wide ge...

journal_title：Cell reports

authors： Chen WW,Birsoy K,Mihaylova MM,Snitkin H,Stasinski I,Yucel B,Bayraktar EC,Carette JE,Clish CB,Brummelkamp TR,Sabatini DD,Sabatini DM

更新日期：2014-04-10 00:00:00

abstract：:The Argonaute subfamily of proteins (AGO) loads microRNAs (miRNAs) to form the effector complex that mediates target gene silencing. Empty AGO, but not miRNA-loaded AGO, is selectively degraded across species. We have reported that the degradation of empty AGO is part of a quality control pathway that eliminates dysfu...

journal_title：Cell reports

authors： Kobayashi H,Shoji K,Kiyokawa K,Negishi L,Tomari Y

更新日期：2019-07-30 00:00:00

abstract：:Plant glutamate receptor homologs (GLRs) have long been proposed to function as ligand-gated Ca2+ channels, but no in planta evidence has been provided. Here, we present genetic evidence that Arabidopsis GLR3.1 and GLR3.5 form Ca2+ channels activated by L-methionine (L-Met) at physiological concentrations and regulate...

journal_title：Cell reports

authors： Kong D,Hu HC,Okuma E,Lee Y,Lee HS,Munemasa S,Cho D,Ju C,Pedoeim L,Rodriguez B,Wang J,Im W,Murata Y,Pei ZM,Kwak JM

更新日期：2016-12-06 00:00:00

abstract：:The lipid transporters of the phosphatidylinositol transfer protein (PITP) family dictate phosphoinositide compartmentalization, and specific phosphoinositides play crucial roles in signaling cascades, membrane traffic, ion channel regulation, and actin dynamics. Although PITPs are enriched in the brain, their physiol...

journal_title：Cell reports

authors： Ashlin TG,Blunsom NJ,Ghosh M,Cockcroft S,Rihel J

更新日期：2018-08-07 00:00:00

abstract：:Plasmodium parasites infect the liver and replicate inside hepatocytes before they invade erythrocytes and trigger clinical malaria. Analysis of host signaling pathways affected by liver-stage infection could provide critical insights into host-pathogen interactions and reveal targets for intervention. Using protein l...

journal_title：Cell reports

authors： Kaushansky A,Ye AS,Austin LS,Mikolajczak SA,Vaughan AM,Camargo N,Metzger PG,Douglass AN,MacBeath G,Kappe SH

更新日期：2013-03-28 00:00:00

abstract：:Trimethylated H3K27 (H3K27me3) is associated with transcriptional repression, and its abundance in chromatin is frequently altered in cancer. However, it has remained unclear how genomic regions modified by H3K27me3 are specified and formed. We previously showed that downregulation of transcription by oncogenic Ras si...

journal_title：Cell reports

authors： Hosogane M,Funayama R,Shirota M,Nakayama K

更新日期：2016-07-19 00:00:00

abstract：:Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in regulating the actomyosin network by suppressing Rho GTPase in medaka fish. Here, we identify Rho GTPase activating protein 29 (ARHGAP29) as a transc...

journal_title：Cell reports

authors： Qiao Y,Chen J,Lim YB,Finch-Edmondson ML,Seshachalam VP,Qin L,Jiang T,Low BC,Singh H,Lim CT,Sudol M

更新日期：2017-05-23 00:00:00

abstract：:Within the field of computational neuroscience there are great expectations of finding new ways to rebalance the complex dynamic system of the human brain through controlled pharmacological or electromagnetic perturbation. Yet many obstacles remain between the ability to accurately predict how and where best to pertur...

journal_title：Cell reports

authors： Kringelbach ML,Deco G

更新日期：2020-09-08 00:00:00

abstract：:Zika virus (ZIKV) is an emerging, mosquito-borne flavivirus responsible for recent epidemics across the Americas, and it is closely related to dengue virus (DENV). Here, we study samples from 46 DENV-naive and 43 DENV-immune patients with RT-PCR-confirmed ZIKV infection at early-acute, late-acute, and convalescent tim...

journal_title：Cell reports

authors： Michlmayr D,Kim EY,Rahman AH,Raghunathan R,Kim-Schulze S,Che Y,Kalayci S,Gümüş ZH,Kuan G,Balmaseda A,Kasarskis A,Wolinsky SM,Suaréz-Fariñas M,Harris E

更新日期：2020-04-28 00:00:00

abstract：:LIN28 is an RNA binding protein that plays crucial roles in pluripotency, glucose metabolism, tissue regeneration, and tumorigenesis. LIN28 binds to the let-7 primary and precursor microRNAs through bipartite recognition and induces degradation of let-7 precursors (pre-let-7) by promoting oligouridylation by terminal ...

journal_title：Cell reports

authors： Wang L,Nam Y,Lee AK,Yu C,Roth K,Chen C,Ransey EM,Sliz P

更新日期：2017-03-14 00:00:00

abstract：:Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β precursor protein (AP...

journal_title：Cell reports

authors： Park G,Nhan HS,Tyan SH,Kawakatsu Y,Zhang C,Navarro M,Koo EH

更新日期：2020-06-30 00:00:00

abstract：:Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)-18 and driving an essential interferon (IFN)-γ response that primes casp...

journal_title：Cell reports

authors： Kovacs SB,Oh C,Maltez VI,McGlaughon BD,Verma A,Miao EA,Aachoui Y

更新日期：2020-07-28 00:00:00

abstract：:Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...

journal_title：Cell reports

authors： Takahashi Y,Sekine K,Kin T,Takebe T,Taniguchi H

更新日期：2018-05-08 00:00:00

abstract：:DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental and cellular processes and ...

journal_title：Cell reports

authors： Veland N,Hardikar S,Zhong Y,Gayatri S,Dan J,Strahl BD,Rothbart SB,Bedford MT,Chen T

更新日期：2017-12-19 00:00:00

abstract：:Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC), frequent activation of HIF signaling induces a metabolic switch that promotes tumorigenesis. Here, we demonstrate that PGC...

journal_title：Cell reports

authors： LaGory EL,Wu C,Taniguchi CM,Ding CC,Chi JT,von Eyben R,Scott DA,Richardson AD,Giaccia AJ

更新日期：2015-07-07 00:00:00

abstract：:Kainate receptors (KARs) mediate postsynaptic currents with a key impact on neuronal excitability. However, the molecular determinants controlling KAR postsynaptic localization and stabilization are poorly understood. Here, we exploit optogenetic and single-particle tracking approaches to study the role of KAR conform...

journal_title：Cell reports

authors： Polenghi A,Nieus T,Guazzi S,Gorostiza P,Petrini EM,Barberis A

更新日期：2020-06-09 00:00:00

abstract：:Activation of the transcription factor NF-κB is essential for innate immune function and requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc deficiency is associated with elevated inflammation and worse outcomes in response to bacterial infection and sepsis. Previous studies sugg...

journal_title：Cell reports

authors： Liu MJ,Bao S,Gálvez-Peralta M,Pyle CJ,Rudawsky AC,Pavlovicz RE,Killilea DW,Li C,Nebert DW,Wewers MD,Knoell DL

更新日期：2013-02-21 00:00:00

abstract：:Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma. Type 2 innate lymphoid cells (ILC2s) represent the major player in allergic airway inflam...

journal_title：Cell reports

authors： He J,Yang Q,Xiao Q,Lei A,Li X,Zhou P,Liu T,Zhang L,Shi K,Yang Q,Dong J,Zhou J

更新日期：2019-11-26 00:00:00

abstract：:Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human (HeLa) cells, and ...

journal_title：Cell reports

authors： Weinert BT,Schölz C,Wagner SA,Iesmantavicius V,Su D,Daniel JA,Choudhary C

更新日期：2013-08-29 00:00:00

abstract：:One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS), who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack ...

journal_title：Cell reports

authors： Nissan X,Blondel S,Navarro C,Maury Y,Denis C,Girard M,Martinat C,De Sandre-Giovannoli A,Levy N,Peschanski M

更新日期：2012-07-26 00:00:00

abstract：:Evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain called outer radial glia (oRG). oRG cells display a characteristic division mode, mitotic somal translocation (MST), in which the soma rapidly translocates toward the cortical plate imm...

journal_title：Cell reports

authors： Ostrem BE,Lui JH,Gertz CC,Kriegstein AR

更新日期：2014-08-07 00:00:00