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Molecular and Cellular Organization of Taste Neurons in Adult Drosophila Pharynx.

Abstract：

:The Drosophila pharyngeal taste organs are poorly characterized despite their location at important sites for monitoring food quality. Functional analysis of pharyngeal neurons has been hindered by the paucity of molecular tools to manipulate them, as well as their relative inaccessibility for neurophysiological investigations. Here, we generate receptor-to-neuron maps of all three pharyngeal taste organs by performing a comprehensive chemoreceptor-GAL4/LexA expression analysis. The organization of pharyngeal neurons reveals similarities and distinctions in receptor repertoires and neuronal groupings compared to external taste neurons. We validate the mapping results by pinpointing a single pharyngeal neuron required for feeding avoidance of L-canavanine. Inducible activation of pharyngeal taste neurons reveals functional differences between external and internal taste neurons and functional subdivision within pharyngeal sweet neurons. Our results provide roadmaps of pharyngeal taste organs in an insect model system for probing the role of these understudied neurons in controlling feeding behaviors.

journal_name

Cell Rep

journal_title

Cell reports

authors

Chen YD,Dahanukar A

doi

10.1016/j.celrep.2017.11.041

subject

Has Abstract

pub_date

2017-12-05 00:00:00

pages

2978-2991

issue

10

issn

2211-1247

pii

S2211-1247(17)31678-9

journal_volume

21

pub_type

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