当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis.

YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis.

Abstract：

:Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in regulating the actomyosin network by suppressing Rho GTPase in medaka fish. Here, we identify Rho GTPase activating protein 29 (ARHGAP29) as a transcriptional target of YAP in a human gastric cancer cell line. YAP promotes the expression of ARHGAP29 to suppress the RhoA-LIMK-cofilin pathway, destabilizing F-actin. The overexpression of YAP causes cytoskeletal rearrangement by altering the dynamics of F-actin/G-actin turnover, thus promoting migration. In a mouse model, circulating tumor cells (CTCs) exhibit an increased ARHGAP29 RNA level compared with cells at primary tumor sites, and the metastatic potential of CTCs is positively correlated with ARHGAP29 expression. Moreover, increased ARHGAP29 expression is correlated with shortened survival of human gastric cancer patients. Our study provides a model to understand YAP's contribution to cancer metastasis via regulation of actin dynamics.

journal_name

Cell Rep

journal_title

Cell reports

authors

Qiao Y,Chen J,Lim YB,Finch-Edmondson ML,Seshachalam VP,Qin L,Jiang T,Low BC,Singh H,Lim CT,Sudol M

doi

10.1016/j.celrep.2017.04.075

subject

Has Abstract

pub_date

2017-05-23 00:00:00

pages

1495-1502

issue

8

issn

2211-1247

pii

S2211-1247(17)30604-6

journal_volume

19

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.

    abstract：:Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo. Analysis of resting microglia identified 29 genes that distinguish mic...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.06.018

    authors： Chiu IM,Morimoto ET,Goodarzi H,Liao JT,O'Keeffe S,Phatnani HP,Muratet M,Carroll MC,Levy S,Tavazoie S,Myers RM,Maniatis T

    更新日期：2013-07-25 00:00:00

  • Non-acylated Wnts Can Promote Signaling.

    abstract：:Wnts are a family of 19 extracellular ligands that regulate cell fate, proliferation, and migration during metazoan embryogenesis and throughout adulthood. Wnts are acylated post-translationally at a conserved serine and bind the extracellular cysteine-rich domain (CRD) of Frizzled (FZD) seven-pass transmembrane recep...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.12.104

    authors： Speer KF,Sommer A,Tajer B,Mullins MC,Klein PS,Lemmon MA

    更新日期：2019-01-22 00:00:00

  • Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.

    abstract：:Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer (NK)...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.07.021

    authors： Huang X,Li J,Dorta-Estremera S,Di Domizio J,Anthony SM,Watowich SS,Popkin D,Liu Z,Brohawn P,Yao Y,Schluns KS,Lanier LL,Cao W

    更新日期：2015-08-18 00:00:00

  • Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2.

    abstract：:Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms largely unknown. We here revealed an intramolecular interaction of the TRPP3...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.01.042

    authors： Zheng W,Cai R,Hofmann L,Nesin V,Hu Q,Long W,Fatehi M,Liu X,Hussein S,Kong T,Li J,Light PE,Tang J,Flockerzi V,Tsiokas L,Chen XZ

    更新日期：2018-02-06 00:00:00

  • Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2.

    abstract：:Communication between organelles plays key roles in cell biology. In particular, physical and functional coupling of the endoplasmic reticulum (ER) and mitochondria is crucial for regulation of various physiological and pathophysiological processes. Here, we demonstrate that Presenilin 2 (PS2), mutations in which unde...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.05.013

    authors： Filadi R,Greotti E,Turacchio G,Luini A,Pozzan T,Pizzo P

    更新日期：2016-06-07 00:00:00

  • NAADP mediates insulin-stimulated glucose uptake and insulin sensitization by PPARγ in adipocytes.

    abstract：:Insulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Peroxisome proliferator-activated receptor γ (PPARγ) enhances insulin sensitivity. Here, we demonstrate that insulin stimulates GLUT4 and GLUT1 translocation, and glucose uptake, by activating the signaling pathway involving nicot...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.10.018

    authors： Song EK,Lee YR,Kim YR,Yeom JH,Yoo CH,Kim HK,Park HM,Kang HS,Kim JS,Kim UH,Han MK

    更新日期：2012-12-27 00:00:00

  • VEGF-A from Granuloma Macrophages Regulates Granulomatous Inflammation by a Non-angiogenic Pathway during Mycobacterial Infection.

    abstract：:Many autoimmune and infectious diseases are characterized by the formation of granulomas which are inflammatory lesions that consist of spatially organized immune cells. These sites protect the host and control pathogens like Mycobacterium tuberculosis (Mtb), but are highly inflammatory and cause pathology. Using baci...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.04.072

    authors： Harding JS,Herbath M,Chen Y,Rayasam A,Ritter A,Csoka B,Hasko G,Michael IP,Fabry Z,Nagy A,Sandor M

    更新日期：2019-05-14 00:00:00

  • The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency.

    abstract：:Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ) pool and result in the generation of reactive oxygen species. To...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.03.009

    authors： Guarás A,Perales-Clemente E,Calvo E,Acín-Pérez R,Loureiro-Lopez M,Pujol C,Martínez-Carrascoso I,Nuñez E,García-Marqués F,Rodríguez-Hernández MA,Cortés A,Diaz F,Pérez-Martos A,Moraes CT,Fernández-Silva P,Trifunovic A,Navas

    更新日期：2016-04-05 00:00:00

  • Macrohistone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming to pluripotency.

    abstract：:Transcription-factor-induced reprogramming of somatic cells to pluripotency is a very inefficient process, probably due to the existence of important epigenetic barriers that are imposed during differentiation and that contribute to preserving cell identity. In an effort to decipher the molecular nature of these barri...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.02.029

    authors： Barrero MJ,Sese B,Kuebler B,Bilic J,Boue S,Martí M,Izpisua Belmonte JC

    更新日期：2013-04-25 00:00:00

  • Fungicidal drugs induce a common oxidative-damage cellular death pathway.

    abstract：:Amphotericin, miconazole, and ciclopirox are antifungal agents from three different drug classes that can effectively kill planktonic yeast, yet their complete fungicidal mechanisms are not fully understood. Here, we employ a systems biology approach to identify a common oxidative-damage cellular death pathway trigger...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.12.021

    authors： Belenky P,Camacho D,Collins JJ

    更新日期：2013-02-21 00:00:00

  • Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms.

    abstract：:Chromothripsis represents a novel phenomenon in the structural variation landscape of cancer genomes. Here, we analyze the genomes of ten patients with congenital disease who were preselected to carry complex chromosomal rearrangements with more than two breakpoints. The rearrangements displayed unanticipated complexi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.05.009

    authors： Kloosterman WP,Tavakoli-Yaraki M,van Roosmalen MJ,van Binsbergen E,Renkens I,Duran K,Ballarati L,Vergult S,Giardino D,Hansson K,Ruivenkamp CA,Jager M,van Haeringen A,Ippel EF,Haaf T,Passarge E,Hochstenbach R,Menten B,

    更新日期：2012-06-28 00:00:00

  • Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis.

    abstract：:Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.005

    authors： Traub S,Meier DT,Schulze F,Dror E,Nordmann TM,Goetz N,Koch N,Dalmas E,Stawiski M,Makshana V,Thorel F,Herrera PL,Böni-Schnetzler M,Donath MY

    更新日期：2017-03-28 00:00:00

  • Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding.

    abstract：:Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two opp...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.09.002

    authors： Delpretti S,Montavon T,Leleu M,Joye E,Tzika A,Milinkovitch M,Duboule D

    更新日期：2013-10-17 00:00:00

  • Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells.

    abstract：:In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. This system was...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.06.067

    authors： Monfort A,Di Minin G,Postlmayr A,Freimann R,Arieti F,Thore S,Wutz A

    更新日期：2015-07-28 00:00:00

  • Inferring Active Metabolic Pathways from Proteomics and Essentiality Data.

    abstract：:Here, we propose an approach to identify active metabolic pathways by integrating gene essentiality analysis and protein abundance. We use two bacterial species (Mycoplasma pneumoniae and Mycoplasma agalactiae) that share a high gene content similarity yet show significant metabolic differences. First, we build detail...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107722

    authors： Montero-Blay A,Piñero-Lambea C,Miravet-Verde S,Lluch-Senar M,Serrano L

    更新日期：2020-06-02 00:00:00

  • DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.

    abstract：:Embryonic stem cells (ESCs) exhibit high levels of ribosomal RNA (rRNA) transcription and ribosome biogenesis. Here, we reveal an unexpected role for an essential DEAD-box helicase, DDX18, in antagonizing the polycomb repressive complex 2 (PRC2) to prevent deposition of the repressive H3K27me3 mark onto rDNA in plurip...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.12.021

    authors： Zhang H,Wu Z,Lu JY,Huang B,Zhou H,Xie W,Wang J,Shen X

    更新日期：2020-01-07 00:00:00

  • The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes.

    abstract：:Neurodegenerative disorders are a major public health problem because of the high frequency of these diseases. Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders. We designed the KamiCas9 self-inactivating editing system to achieve transient expre...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.075

    authors： Merienne N,Vachey G,de Longprez L,Meunier C,Zimmer V,Perriard G,Canales M,Mathias A,Herrgott L,Beltraminelli T,Maulet A,Dequesne T,Pythoud C,Rey M,Pellerin L,Brouillet E,Perrier AL,du Pasquier R,Déglon N

    更新日期：2017-09-19 00:00:00

  • miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.

    abstract：:MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells follow...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.060

    authors： Chen Z,Stelekati E,Kurachi M,Yu S,Cai Z,Manne S,Khan O,Yang X,Wherry EJ

    更新日期：2017-09-12 00:00:00

  • Chd5 requires PHD-mediated histone 3 binding for tumor suppression.

    abstract：:Chromodomain Helicase DNA binding protein 5 (CHD5) is a tumor suppressor mapping to 1p36, a genomic region that is frequently deleted in human cancer. Although CHD5 belongs to the CHD family of chromatin-remodeling proteins, whether its tumor-suppressive role involves an interaction with chromatin is unknown. Here we ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.12.009

    authors： Paul S,Kuo A,Schalch T,Vogel H,Joshua-Tor L,McCombie WR,Gozani O,Hammell M,Mills AA

    更新日期：2013-01-31 00:00:00

  • Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection.

    abstract：:Residual cell-intrinsic innate immunity in cancer cells hampers infection with oncolytic viruses. Translational control of mRNA is an important feature of innate immunity, yet the identity of translationally regulated mRNAs functioning in host defense remains ill-defined. We report the translatomes of resistant murine...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.072

    authors： Hoang HD,Graber TE,Jia JJ,Vaidya N,Gilchrist VH,Xiang X,Li W,Cowan KN,Gkogkas CG,Jaramillo M,Jafarnejad SM,Alain T

    更新日期：2019-12-17 00:00:00

  • Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice.

    abstract：:The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that i...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108507

    authors： Todd L,Finkbeiner C,Wong CK,Hooper MJ,Reh TA

    更新日期：2020-12-15 00:00:00

  • Opiates modulate thermosensation by internalizing cold receptor TRPM8.

    abstract：:Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests itself with severe symptoms, including cold hyperalgesia, often preventing addicted patients from successfully completing the rehabi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.07.002

    authors： Shapovalov G,Gkika D,Devilliers M,Kondratskyi A,Gordienko D,Busserolles J,Bokhobza A,Eschalier A,Skryma R,Prevarskaya N

    更新日期：2013-08-15 00:00:00

  • Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA.

    abstract：:Clericuzio-type poikiloderma with neutropenia (PN) is a rare genodermatosis associated with mutations in the C16orf57 gene, which codes for the uncharacterized protein hMpn1. We show here that, in both fission yeasts and humans, Mpn1 processes the spliceosomal U6 small nuclear RNA (snRNA) posttranscriptionally. In Mpn...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.08.031

    authors： Shchepachev V,Wischnewski H,Missiaglia E,Soneson C,Azzalin CM

    更新日期：2012-10-25 00:00:00

  • Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.

    abstract：:GPR116 is an orphan seven-pass transmembrane receptor whose function has been unclear. Global disruption of the Gpr116 gene in mice revealed an unexpected, critical role for this receptor in lung surfactant homeostasis, resulting in progressive accumulation of surfactant lipids and proteins in the alveolar space, labo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.04.019

    authors： Yang MY,Hilton MB,Seaman S,Haines DC,Nagashima K,Burks CM,Tessarollo L,Ivanova PT,Brown HA,Umstead TM,Floros J,Chroneos ZC,St Croix B

    更新日期：2013-05-30 00:00:00

  • The Hidden Spatial Dimension of Alpha: 10-Hz Perceptual Echoes Propagate as Periodic Traveling Waves in the Human Brain.

    abstract：:EEG reverse-correlation techniques have revealed that visual information processing entails a ∼10-Hz (alpha) occipital response that reverberates sensory inputs up to 1 s. However, the spatial distribution of these perceptual echoes remains unknown: are they synchronized across the brain, or do they propagate like a t...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.12.058

    authors： Lozano-Soldevilla D,VanRullen R

    更新日期：2019-01-08 00:00:00

  • A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome.

    abstract：:Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized by severe hyperphagia. We fou...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.018

    authors： Bochukova EG,Lawler K,Croizier S,Keogh JM,Patel N,Strohbehn G,Lo KK,Humphrey J,Hokken-Koelega A,Damen L,Donze S,Bouret SG,Plagnol V,Farooqi IS

    更新日期：2018-03-27 00:00:00

  • Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2+ Granule Neuron Precursor.

    abstract：:Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2+ cells at the apex of tumor progression and relapse. To test whether this mechanism is rooted in a normal developmental process, we studie...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.03.075

    authors： Selvadurai HJ,Luis E,Desai K,Lan X,Vladoiu MC,Whitley O,Galvin C,Vanner RJ,Lee L,Whetstone H,Kushida M,Nowakowski T,Diamandis P,Hawkins C,Bader G,Kriegstein A,Taylor MD,Dirks PB

    更新日期：2020-04-14 00:00:00

  • Functional genomic analysis of human mitochondrial RNA processing.

    abstract：:Both strands of human mtDNA are transcribed in continuous, multigenic units that are cleaved into the mature rRNAs, tRNAs, and mRNAs required for respiratory chain biogenesis. We sought to systematically identify nuclear-encoded proteins that contribute to processing of mtRNAs within the organelle. First, we devised a...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.03.035

    authors： Wolf AR,Mootha VK

    更新日期：2014-05-08 00:00:00

  • A Targeted Multi-omic Analysis Approach Measures Protein Expression and Low-Abundance Transcripts on the Single-Cell Level.

    abstract：:High-throughput single-cell RNA sequencing (scRNA-seq) has become a frequently used tool to assess immune cell heterogeneity. Recently, the combined measurement of RNA and protein expression was developed, commonly known as cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq). Acquisition of prote...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.03.063

    authors： Mair F,Erickson JR,Voillet V,Simoni Y,Bi T,Tyznik AJ,Martin J,Gottardo R,Newell EW,Prlic M

    更新日期：2020-04-07 00:00:00

  • Control of outer radial glial stem cell mitosis in the human brain.

    abstract：:Evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain called outer radial glia (oRG). oRG cells display a characteristic division mode, mitotic somal translocation (MST), in which the soma rapidly translocates toward the cortical plate imm...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.058

    authors： Ostrem BE,Lui JH,Gertz CC,Kriegstein AR

    更新日期：2014-08-07 00:00:00