当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.

Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.

Abstract：

:Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer (NK) cells. IFN-α/β produced by pDCs activated NK cells via IL-15 induction. Neutrophils released reactive oxygen species (ROS), which negatively modulated the levels of IL-15, thereby inhibiting IFN-γ production. Mice deficient in NADPH oxidase 2 produced increased amounts of IFN-γ and developed augmented titers of autoantibodies. Both the pDC-IFN-α/β pathway and IFN-γ were indispensable in stimulating humoral autoimmunity. Male NZB/W F1 mice expressed higher levels of superoxide than their female lupus-prone siblings, and depletion of neutrophils resulted in spontaneous NK cell and autoimmune B cell activation. Our findings suggest a regulatory role for neutrophils in vivo and highlight the importance of an NK-IFN-γ axis downstream of the pDC-IFN-α/β pathway in systemic autoimmunity.

journal_name

Cell Rep

journal_title

Cell reports

authors

Huang X,Li J,Dorta-Estremera S,Di Domizio J,Anthony SM,Watowich SS,Popkin D,Liu Z,Brohawn P,Yao Y,Schluns KS,Lanier LL,Cao W

doi

10.1016/j.celrep.2015.07.021

subject

Has Abstract

pub_date

2015-08-18 00:00:00

pages

1120-32

issue

7

issn

2211-1247

pii

S2211-1247(15)00761-5

journal_volume

12

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function.

    abstract：:53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficient cancers. In this study, we show that FOXK1 associates with 53BP1 and regula...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108018

    authors： Tang M,Feng X,Pei G,Srivastava M,Wang C,Chen Z,Li S,Zhang H,Zhao Z,Li X,Chen J

    更新日期：2020-08-11 00:00:00

  • Infant and Adult Gut Microbiome and Metabolome in Rural Bassa and Urban Settlers from Nigeria.

    abstract：:We assessed the subsistence-related variation of the human gut microbiome at a fine resolution for two of the main dimensions of microbiome variation, age and geography. For this, we investigated the fecal microbiome and metabolome in rural Bassa and urbanized individuals from Nigeria, including infants, and compared ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.05.018

    authors： Ayeni FA,Biagi E,Rampelli S,Fiori J,Soverini M,Audu HJ,Cristino S,Caporali L,Schnorr SL,Carelli V,Brigidi P,Candela M,Turroni S

    更新日期：2018-06-05 00:00:00

  • RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling.

    abstract：:Long-lasting forms of synaptic plasticity such as synaptic scaling are critically dependent on transcription. Activity-dependent transcriptional dynamics in neurons, however, remain incompletely characterized because most previous efforts relied on measurement of steady-state mRNAs. Here, we use nascent RNA sequencing...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108002

    authors： Garay PM,Chen A,Tsukahara T,Rodríguez Díaz JC,Kohen R,Althaus JC,Wallner MA,Giger RJ,Jones KS,Sutton MA,Iwase S

    更新日期：2020-08-11 00:00:00

  • Suppression of host p53 is critical for Plasmodium liver-stage infection.

    abstract：:Plasmodium parasites infect the liver and replicate inside hepatocytes before they invade erythrocytes and trigger clinical malaria. Analysis of host signaling pathways affected by liver-stage infection could provide critical insights into host-pathogen interactions and reveal targets for intervention. Using protein l...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.02.010

    authors： Kaushansky A,Ye AS,Austin LS,Mikolajczak SA,Vaughan AM,Camargo N,Metzger PG,Douglass AN,MacBeath G,Kappe SH

    更新日期：2013-03-28 00:00:00

  • Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis.

    abstract：:Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregulate the sympathetic nerve fiber (SNF) modulator Neuregulin 4 (Nrg4), activate ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107998

    authors： Henriques F,Bedard AH,Guilherme A,Kelly M,Chi J,Zhang P,Lifshitz LM,Bellvé K,Rowland LA,Yenilmez B,Kumar S,Wang Y,Luban J,Weinstein LS,Lin JD,Cohen P,Czech MP

    更新日期：2020-08-04 00:00:00

  • Global Reprogramming of Host SUMOylation during Influenza Virus Infection.

    abstract：:Dynamic nuclear SUMO modifications play essential roles in orchestrating cellular responses to proteotoxic stress, DNA damage, and DNA virus infection. Here, we describe a non-canonical host SUMOylation response to the nuclear-replicating RNA pathogen, influenza virus, and identify viral RNA polymerase activity as a m...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.10.001

    authors： Domingues P,Golebiowski F,Tatham MH,Lopes AM,Taggart A,Hay RT,Hale BG

    更新日期：2015-11-17 00:00:00

  • Direct Comparison of Mononucleated and Binucleated Cardiomyocytes Reveals Molecular Mechanisms Underlying Distinct Proliferative Competencies.

    abstract：:The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more responsive than are binucleated cardiomyocytes to pro-proliferative stimuli. We...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.02.034

    authors： Windmueller R,Leach JP,Babu A,Zhou S,Morley MP,Wakabayashi A,Petrenko NB,Viatour P,Morrisey EE

    更新日期：2020-03-03 00:00:00

  • In Vivo Estimates of Liver Metabolic Flux Assessed by 13C-Propionate and 13C-Lactate Are Impacted by Tracer Recycling and Equilibrium Assumptions.

    abstract：:Isotope-based assessment of metabolic flux is achieved through a judicious balance of measurements and assumptions. Recent publications debate the validity of key assumptions used to model stable isotope labeling of liver metabolism in vivo. Here, we examine the controversy surrounding estimates of liver citric acid c...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107986

    authors： Hasenour CM,Rahim M,Young JD

    更新日期：2020-08-04 00:00:00

  • Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase.

    abstract：:Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular fractionation, we pro...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.11.018

    authors： Quan Y,Xia Y,Liu L,Cui J,Li Z,Cao Q,Chen XS,Campbell JL,Lou H

    更新日期：2015-12-22 00:00:00

  • Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.

    abstract：:Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. However, recent work also shows that key molecular aspects of human END regulation differ even from rodents. Differentiation of human embryonic stem cells (ESCs) to END offers a tractable system to study the mole...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.03.076

    authors： Genga RMJ,Kernfeld EM,Parsi KM,Parsons TJ,Ziller MJ,Maehr R

    更新日期：2019-04-16 00:00:00

  • Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos.

    abstract：:The development of an embryo requires precise spatiotemporal regulation of cellular processes. During Drosophila gastrulation, a precise temporal pattern of cell division is encoded through transcriptional regulation of cdc25(string) in 25 distinct mitotic domains. Using a genetic screen, we demonstrate that the same ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.08.034

    authors： Momen-Roknabadi A,Di Talia S,Wieschaus E

    更新日期：2016-09-13 00:00:00

  • Sleep Induction by Mechanosensory Stimulation in Drosophila.

    abstract：:People tend to fall asleep when gently rocked or vibrated. Experimental studies have shown that rocking promotes sleep in humans and mice. However, the mechanisms underlying the phenomenon are not well understood. A habituation model proposes that habituation, a form of non-associative learning, mediates sleep inducti...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108462

    authors： Öztürk-Çolak A,Inami S,Buchler JR,McClanahan PD,Cruz A,Fang-Yen C,Koh K

    更新日期：2020-12-01 00:00:00

  • Conversion of MyoD to a neurogenic factor: binding site specificity determines lineage.

    abstract：:MyoD and NeuroD2, master regulators of myogenesis and neurogenesis, bind to a "shared" E-box sequence (CAGCTG) and a "private" sequence (CAGGTG or CAGATG, respectively). To determine whether private-site recognition is sufficient to confer lineage specification, we generated a MyoD mutant with the DNA-binding specific...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.02.055

    authors： Fong AP,Yao Z,Zhong JW,Johnson NM,Farr GH 3rd,Maves L,Tapscott SJ

    更新日期：2015-03-31 00:00:00

  • DNA copy-number control through inhibition of replication fork progression.

    abstract：:Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly,...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.10.005

    authors： Nordman JT,Kozhevnikova EN,Verrijzer CP,Pindyurin AV,Andreyeva EN,Shloma VV,Zhimulev IF,Orr-Weaver TL

    更新日期：2014-11-06 00:00:00

  • Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance.

    abstract：:Some epigenetic modifications are inherited from one generation to the next, providing a potential mechanism for the inheritance of environmentally acquired traits. Transgenerational inheritance of RNAi phenotypes in Caenorhabditis elegans provides an excellent model to study this phenomenon, and although studies have...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.085

    authors： Woodhouse RM,Buchmann G,Hoe M,Harney DJ,Low JKK,Larance M,Boag PR,Ashe A

    更新日期：2018-11-20 00:00:00

  • In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.

    abstract：:HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a "block-and-lock" functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA). HIV-1 transcriptional inhibitors could block ongoing viremia during antiretrov...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.09.080

    authors： Kessing CF,Nixon CC,Li C,Tsai P,Takata H,Mousseau G,Ho PT,Honeycutt JB,Fallahi M,Trautmann L,Garcia JV,Valente ST

    更新日期：2017-10-17 00:00:00

  • HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact.

    abstract：:HIV-1 is transmitted between T cells through the release of cell-free particles and through cell-cell contact. Cell-to-cell transmission is more efficient than cell-free virus transmission, mediates resistance to immune responses, and facilitates the spread of virus among T cells. However, whether HIV cell-to-cell tra...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.079

    authors： Agosto LM,Herring MB,Mothes W,Henderson AJ

    更新日期：2018-08-21 00:00:00

  • Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21.

    abstract：:Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we observe repression of host glycolysis in Mtb-infected macrophages, which is dependent on sustained u...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.12.015

    authors： Hackett EE,Charles-Messance H,O'Leary SM,Gleeson LE,Muñoz-Wolf N,Case S,Wedderburn A,Johnston DGW,Williams MA,Smyth A,Ouimet M,Moore KJ,Lavelle EC,Corr SC,Gordon SV,Keane J,Sheedy FJ

    更新日期：2020-01-07 00:00:00

  • Chaperoning HMGA2 protein protects stalled replication forks in stem and cancer cells.

    abstract：:Maintaining genome integrity requires the accurate and complete replication of chromosomal DNA. This is of the utmost importance for embryonic stem cells (ESCs), which differentiate into cells of all lineages, including germ cells. However, endogenous and exogenous factors frequently induce stalling of replication for...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.01.014

    authors： Yu H,Lim HH,Tjokro NO,Sathiyanathan P,Natarajan S,Chew TW,Klonisch T,Goodman SD,Surana U,Dröge P

    更新日期：2014-02-27 00:00:00

  • Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1.

    abstract：:Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.10.063

    authors： Nersesyan Y,Demirkhanyan L,Cabezas-Bratesco D,Oakes V,Kusuda R,Dawson T,Sun X,Cao C,Cohen AM,Chelluboina B,Veeravalli KK,Zimmermann K,Domene C,Brauchi S,Zakharian E

    更新日期：2017-11-07 00:00:00

  • Interphase Microtubules Safeguard Mitotic Progression by Suppressing an Aurora B-Dependent Arrest Induced by DNA Replication Stress.

    abstract：:The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or active regulators of the process. We show...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.02.051

    authors： Laflamme G,Sim S,Leary A,Pascariu M,Vogel J,D'Amours D

    更新日期：2019-03-12 00:00:00

  • Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection.

    abstract：:Residual cell-intrinsic innate immunity in cancer cells hampers infection with oncolytic viruses. Translational control of mRNA is an important feature of innate immunity, yet the identity of translationally regulated mRNAs functioning in host defense remains ill-defined. We report the translatomes of resistant murine...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.072

    authors： Hoang HD,Graber TE,Jia JJ,Vaidya N,Gilchrist VH,Xiang X,Li W,Cowan KN,Gkogkas CG,Jaramillo M,Jafarnejad SM,Alain T

    更新日期：2019-12-17 00:00:00

  • Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination.

    abstract：:The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin detyrosinating activity. Moreover, we demonstrate that SVBP acts as a bona...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.074

    authors： van der Laan S,Lévêque MF,Marcellin G,Vezenkov L,Lannay Y,Dubra G,Bompard G,Ovejero S,Urbach S,Burgess A,Amblard M,Sterkers Y,Bastien P,Rogowski K

    更新日期：2019-12-17 00:00:00

  • Subcellular Imbalances in Synaptic Activity.

    abstract：:The dynamic interactions between synaptic excitation and inhibition (E/I) shape membrane potential fluctuations and determine patterns of neuronal outputs; however, the spatiotemporal organization of these interactions within a single cell is poorly understood. Here, we investigated the relationship between local syna...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.01.024

    authors： Takahashi N,Kobayashi C,Ishikawa T,Ikegaya Y

    更新日期：2016-02-16 00:00:00

  • Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly.

    abstract：:Tight-junction-regulated actomyosin activity determines epithelial and endothelial tension on adherens junctions and drives morphogenetic processes; however, whether or not tight junctions themselves are under tensile stress is not clear. Here, we use a tension sensor based on ZO-1, a scaffolding protein that links th...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107924

    authors： Haas AJ,Zihni C,Ruppel A,Hartmann C,Ebnet K,Tada M,Balda MS,Matter K

    更新日期：2020-07-21 00:00:00

  • Hsp90 Is Essential under Heat Stress in the Bacterium Shewanella oneidensis.

    abstract：:The Hsp90 chaperone is essential in eukaryotes and activates a large array of client proteins. In contrast, its role is still elusive in bacteria, and only a few Hsp90 bacterial clients are known. Here, we found that Hsp90 is essential in the model bacterium Shewanella oneidensis under heat stress. A genetic screen fo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.082

    authors： Honoré FA,Méjean V,Genest O

    更新日期：2017-04-25 00:00:00

  • Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature.

    abstract：:Mural cells (pericytes and vascular smooth muscle cells) are essential for the regulation of vascular networks and maintenance of vascular integrity, but their origins are diverse in different tissues and not known in the organs that arise from the ectoderm, such as skin. Here, we show that tissue-localized myeloid pr...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.02.069

    authors： Yamazaki T,Nalbandian A,Uchida Y,Li W,Arnold TD,Kubota Y,Yamamoto S,Ema M,Mukouyama YS

    更新日期：2017-03-21 00:00:00

  • Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.

    abstract：:Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibr...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.03.062

    authors： Vila IK,Badin PM,Marques MA,Monbrun L,Lefort C,Mir L,Louche K,Bourlier V,Roussel B,Gui P,Grober J,Štich V,Rossmeislová L,Zakaroff-Girard A,Bouloumié A,Viguerie N,Moro C,Tavernier G,Langin D

    更新日期：2014-05-22 00:00:00

  • An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication.

    abstract：:Eukaryotic DNA replication licensing is a prerequisite for, and plays a role in, regulating genome duplication that occurs exactly once per cell cycle. ORC (origin recognition complex) binds to and marks replication origins throughout the cell cycle and loads other replication-initiation proteins onto replication orig...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.02.046

    authors： Amin A,Wu R,Cheung MH,Scott JF,Wang Z,Zhou Z,Liu C,Zhu G,Wong CK,Yu Z,Liang C

    更新日期：2020-03-10 00:00:00

  • Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.

    abstract：:The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune diseases. G6 is an anti-idiotypic monoclonal Ab that selectively binds to IGHV1-6...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.11.056

    authors： Avnir Y,Prachanronarong KL,Zhang Z,Hou S,Peterson EC,Sui J,Zayed H,Kurella VB,McGuire AT,Stamatatos L,Hilbert BJ,Bohn MF,Kowalik TF,Jensen JD,Finberg RW,Wang JP,Goodall M,Jefferis R,Zhu Q,Kurt Yilmaz N,Schiffer CA

    更新日期：2017-12-12 00:00:00