Abstract：
:We assessed the subsistence-related variation of the human gut microbiome at a fine resolution for two of the main dimensions of microbiome variation, age and geography. For this, we investigated the fecal microbiome and metabolome in rural Bassa and urbanized individuals from Nigeria, including infants, and compared data with worldwide populations practicing varying subsistence. Our data highlight specific microbiome traits that are progressively lost with urbanization, such as the dominance of pristine fiber degraders and the low inter-individual variation. For the Bassa, this last feature is the result of their subsistence-related practices favoring microbial dispersal, such as their extensive environmental contact and the usage of untreated waters from the Usuma River. The high degree of microbial dispersal observed in the Bassa meta-community nullifies the differences between infant and adult intestinal ecosystems, suggesting that the infant-type microbiome in Western populations could be the result of microbiome-associated neotenic traits favored by urbanization.
journal_name
Cell Repjournal_title
Cell reportsauthors
Ayeni FA,Biagi E,Rampelli S,Fiori J,Soverini M,Audu HJ,Cristino S,Caporali L,Schnorr SL,Carelli V,Brigidi P,Candela M,Turroni Sdoi
10.1016/j.celrep.2018.05.018subject
Has Abstractpub_date
2018-06-05 00:00:00pages
3056-3067issue
10issn
2211-1247pii
S2211-1247(18)30751-4journal_volume
23pub_type
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