当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.

Abstract：

:Successful anti-viral response requires the sustained activation and expansion of CD8+ T cells for periods that far exceed the time limit of physical T cell interaction with antigen-presenting cells (APCs). The expanding CD8+ T cell pool generates the effector and memory cell populations that provide viral clearance and long-term immunity, respectively. Here, we demonstrate that 3BP2 is recruited in cytoplasmic microclusters and nucleates a signaling complex that facilitates MHC:peptide-independent activation of signaling pathways downstream of the TCR. We show that induction of the adaptor molecule 3BP2 is a sensor of TCR signal strength and is critical for sustaining CD8+ T cell proliferation and regulating effector and memory differentiation.

journal_name

Cell Rep

journal_title

Cell reports

authors

Dimitriou ID,Lee K,Akpan I,Lind EF,Barr VA,Ohashi PS,Samelson LE,Rottapel R

doi

10.1016/j.celrep.2018.06.075

subject

Has Abstract

pub_date

2018-07-31 00:00:00

pages

1123-1135

issue

5

issn

2211-1247

pii

S2211-1247(18)31002-7

journal_volume

24

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death.

    abstract：:Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe an...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.050

    authors： Galimov ER,Pryor RE,Poole SE,Benedetto A,Pincus Z,Gems D

    更新日期：2018-03-06 00:00:00

  • Subregion-Specific Proteomic Signature in the Hippocampus for Recognition Processes in Adult Mice.

    abstract：:The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.079

    authors： von Ziegler LM,Selevsek N,Tweedie-Cullen RY,Kremer E,Mansuy IM

    更新日期：2018-03-20 00:00:00

  • Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex.

    abstract：:Mutations of WD40-repeat protein 62 (WDR62) have been identified recently to cause human MCPH (autosomal-recessive primary microcephaly), a neurodevelopmental disorder characterized by decreased brain size. However, the underlying mechanism is unclear. Here, we investigate the function of WDR62 in brain development an...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.12.016

    authors： Xu D,Zhang F,Wang Y,Sun Y,Xu Z

    更新日期：2014-01-16 00:00:00

  • Innate immune-directed NF-κB signaling requires site-specific NEMO ubiquitination.

    abstract：:While the I kappa kinase (IKK) scaffolding protein NF-κB essential modulator (NEMO) binds to polyubiquitin chains to transmit inflammatory signals, NEMO itself is also ubiquitinated in response to a variety of inflammatory agonists. Although there have been hints that polyubiquitination of NEMO is essential for avoidi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.06.036

    authors： Jun JC,Kertesy S,Jones MB,Marinis JM,Cobb BA,Tigno-Aranjuez JT,Abbott DW

    更新日期：2013-07-25 00:00:00

  • Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation.

    abstract：:Hypermethylation-mediated tumor suppressor gene (TSG) silencing is a central epigenetic alteration in RAS-dependent tumorigenesis. Ten-eleven translocation (TET) enzymes can depress DNA methylation by hydroxylation of 5-methylcytosine (5mC) bases to 5-hydroxymethylcytosine (5hmC). Here, we report that suppression of T...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.10.063

    authors： Wu BK,Brenner C

    更新日期：2014-12-11 00:00:00

  • Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex.

    abstract：:In contrast to our extensive knowledge on covalent small ubiquitin-like modifier (SUMO) target proteins, we are limited in our understanding of non-covalent SUMO-binding proteins. We identify interactors of different SUMO isoforms-monomeric SUMO1, monomeric SUMO2, or linear trimeric SUMO2 chains-using a mass spectrome...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2021.108691

    authors： González-Prieto R,Eifler-Olivi K,Claessens LA,Willemstein E,Xiao Z,Talavera Ormeno CMP,Ovaa H,Ulrich HD,Vertegaal ACO

    更新日期：2021-01-26 00:00:00

  • PGC1β activates an antiangiogenic program to repress neoangiogenesis in muscle ischemia.

    abstract：:Revascularization of ischemic skeletal muscle is governed by a balance between pro- and antiangiogenic factors in multiple cell types but particularly in myocytes and endothelial cells. Whereas the regulators of proangiogenic factors are well defined (e.g., hypoxia-inducible factor [HIF]), the transcriptional pathways...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.040

    authors： Yadav V,Matsakas A,Lorca S,Narkar VA

    更新日期：2014-08-07 00:00:00

  • Functional Access to Neuron Subclasses in Rodent and Primate Forebrain.

    abstract：:Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive. Here we describe viral promoters and strategies for accessing GABAergic interneurons and their molecularly defined subsets in the...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.02.011

    authors： Mehta P,Kreeger L,Wylie DC,Pattadkal JJ,Lusignan T,Davis MJ,Turi GF,Li WK,Whitmire MP,Chen Y,Kajs BL,Seidemann E,Priebe NJ,Losonczy A,Zemelman BV

    更新日期：2019-03-05 00:00:00

  • Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.

    abstract：:Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of Id genes in adult ECs results in dilated, leaky sinusoids and a pro-inflammatory state that increases in severity ov...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107572

    authors： Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR

    更新日期：2020-04-28 00:00:00

  • Interplay of Histone Marks with Serine ADP-Ribosylation.

    abstract：:Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1). In addition to numerous other targets, core histone tails are primary acceptors of Ser-ADPr in the DNA damage response. Here, we s...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.08.092

    authors： Bartlett E,Bonfiglio JJ,Prokhorova E,Colby T,Zobel F,Ahel I,Matic I

    更新日期：2018-09-25 00:00:00

  • Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors.

    abstract：:Medium spiny neurons (MSNs) of mice show opposing activities upon the initiation of a food-seeking lever press task. Ventromedial striatal (VMS)-MSNs are inhibited but ventrolateral striatal (VLS)-MSNs are activated; these activities mediate action selection and action initiation, respectively. To understand what inpu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107829

    authors： Yoshida K,Tsutsui-Kimura I,Kono A,Yamanaka A,Kobayashi K,Watanabe M,Mimura M,Tanaka KF

    更新日期：2020-06-30 00:00:00

  • VEGF-A from Granuloma Macrophages Regulates Granulomatous Inflammation by a Non-angiogenic Pathway during Mycobacterial Infection.

    abstract：:Many autoimmune and infectious diseases are characterized by the formation of granulomas which are inflammatory lesions that consist of spatially organized immune cells. These sites protect the host and control pathogens like Mycobacterium tuberculosis (Mtb), but are highly inflammatory and cause pathology. Using baci...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.04.072

    authors： Harding JS,Herbath M,Chen Y,Rayasam A,Ritter A,Csoka B,Hasko G,Michael IP,Fabry Z,Nagy A,Sandor M

    更新日期：2019-05-14 00:00:00

  • DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.

    abstract：:Embryonic stem cells (ESCs) exhibit high levels of ribosomal RNA (rRNA) transcription and ribosome biogenesis. Here, we reveal an unexpected role for an essential DEAD-box helicase, DDX18, in antagonizing the polycomb repressive complex 2 (PRC2) to prevent deposition of the repressive H3K27me3 mark onto rDNA in plurip...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.12.021

    authors： Zhang H,Wu Z,Lu JY,Huang B,Zhou H,Xie W,Wang J,Shen X

    更新日期：2020-01-07 00:00:00

  • Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA.

    abstract：:One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS), who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.05.015

    authors： Nissan X,Blondel S,Navarro C,Maury Y,Denis C,Girard M,Martinat C,De Sandre-Giovannoli A,Levy N,Peschanski M

    更新日期：2012-07-26 00:00:00

  • Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation.

    abstract：:T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells. Pharmacological inhibition of cell stress reduces Th17 cell differen...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.05.052

    authors： Brucklacher-Waldert V,Ferreira C,Stebegg M,Fesneau O,Innocentin S,Marie JC,Veldhoen M

    更新日期：2017-06-13 00:00:00

  • Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice.

    abstract：:Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the s...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.087

    authors： Munanairi A,Liu XY,Barry DM,Yang Q,Yin JB,Jin H,Li H,Meng QT,Peng JH,Wu ZY,Yin J,Zhou XY,Wan L,Mo P,Kim S,Huo FQ,Jeffry J,Li YQ,Bardoni R,Bruchas MR,Chen ZF

    更新日期：2018-04-17 00:00:00

  • Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells.

    abstract：:The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator by linking cellular metabolism to substrate AMP-activated protein kinase (AMPK). We show th...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.05.020

    authors： Timilshina M,You Z,Lacher SM,Acharya S,Jiang L,Kang Y,Kim JA,Chang HW,Kim KJ,Park B,Song JH,Ko HJ,Park YY,Ma MJ,Nepal MR,Jeong TC,Chung Y,Waisman A,Chang JH

    更新日期：2019-06-04 00:00:00

  • Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.

    abstract：:Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synaptic function, cognition, and social behavior. However, the role of NBEA...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.04.112

    authors： Gromova KV,Muhia M,Rothammer N,Gee CE,Thies E,Schaefer I,Kress S,Kilimann MW,Shevchuk O,Oertner TG,Kneussel M

    更新日期：2018-05-29 00:00:00

  • Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.

    abstract：:Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, a...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.11.047

    authors： Rupaimoole R,Lee J,Haemmerle M,Ling H,Previs RA,Pradeep S,Wu SY,Ivan C,Ferracin M,Dennison JB,Millward NMZ,Nagaraja AS,Gharpure KM,McGuire M,Sam N,Armaiz-Pena GN,Sadaoui NC,Rodriguez-Aguayo C,Calin GA,Drapkin RI,K

    更新日期：2015-12-22 00:00:00

  • Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates.

    abstract：:Generating mammalian cells with desired mitochondrial DNA (mtDNA) sequences is enabling for studies of mitochondria, disease modeling, and potential regenerative therapies. MitoPunch, a high-throughput mitochondrial transfer device, produces cells with specific mtDNA-nuclear DNA (nDNA) combinations by transferring iso...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108562

    authors： Patananan AN,Sercel AJ,Wu TH,Ahsan FM,Torres A Jr,Kennedy SAL,Vandiver A,Collier AJ,Mehrabi A,Van Lew J,Zakin L,Rodriguez N,Sixto M,Tadros W,Lazar A,Sieling PA,Nguyen TL,Dawson ER,Braas D,Golovato J,Cisneros L,V

    更新日期：2020-12-29 00:00:00

  • Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens.

    abstract：:In humans, Vγ9Vδ2 T cells respond to self and pathogen-associated, diphosphate-containing isoprenoids, also known as phosphoantigens (pAgs). However, activation and homeostasis of Vγ9Vδ2 T cells remain incompletely understood. Here, we show that pAgs induced expression of the ecto-ATPase CD39, which, however, not only...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.06.009

    authors： Gruenbacher G,Gander H,Rahm A,Idzko M,Nussbaumer O,Thurnher M

    更新日期：2016-07-12 00:00:00

  • HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells.

    abstract：:Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in the main target cells of HIV-1 in vivo. Here, we show that activated CD4+ T ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.09.023

    authors： Vermeire J,Roesch F,Sauter D,Rua R,Hotter D,Van Nuffel A,Vanderstraeten H,Naessens E,Iannucci V,Landi A,Witkowski W,Baeyens A,Kirchhoff F,Verhasselt B

    更新日期：2016-10-04 00:00:00

  • The touch dome defines an epidermal niche specialized for mechanosensory signaling.

    abstract：:In mammalian skin, Merkel cells are mechanoreceptor cells that are required for the perception of gentle touch. Recent evidence indicates that mature Merkel cells descend from the proliferative layer of skin epidermis; however, the stem cell niche for Merkel cell homeostasis has not been reported. Here, we provide gen...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.04.026

    authors： Doucet YS,Woo SH,Ruiz ME,Owens DM

    更新日期：2013-06-27 00:00:00

  • Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.

    abstract：:KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood. We report that mutant KRAS regulates intracellular fatty acid metabolism through Acyl-coen...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.07.009

    authors： Padanad MS,Konstantinidou G,Venkateswaran N,Melegari M,Rindhe S,Mitsche M,Yang C,Batten K,Huffman KE,Liu J,Tang X,Rodriguez-Canales J,Kalhor N,Shay JW,Minna JD,McDonald J,Wistuba II,DeBerardinis RJ,Scaglioni PP

    更新日期：2016-08-09 00:00:00

  • The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance.

    abstract：:The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the primary cilium. Additionally, Shh controls axon guidance through a non-canonical...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.015

    authors： Ferent J,Constable S,Gigante ED,Yam PT,Mariani LE,Legué E,Liem KF Jr,Caspary T,Charron F

    更新日期：2019-12-10 00:00:00

  • Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos.

    abstract：:The development of an embryo requires precise spatiotemporal regulation of cellular processes. During Drosophila gastrulation, a precise temporal pattern of cell division is encoded through transcriptional regulation of cdc25(string) in 25 distinct mitotic domains. Using a genetic screen, we demonstrate that the same ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.08.034

    authors： Momen-Roknabadi A,Di Talia S,Wieschaus E

    更新日期：2016-09-13 00:00:00

  • Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells.

    abstract：:In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. This system was...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.06.067

    authors： Monfort A,Di Minin G,Postlmayr A,Freimann R,Arieti F,Thore S,Wutz A

    更新日期：2015-07-28 00:00:00

  • Long-Term Two-Photon Calcium Imaging of Neuronal Populations with Subcellular Resolution in Adult Non-human Primates.

    abstract：:Two-photon imaging with genetically encoded calcium indicators (GECIs) enables long-term observation of neuronal activity in vivo. However, there are very few studies of GECIs in primates. Here, we report a method for long-term imaging of a GECI, GCaMP6f, expressed from adeno-associated virus vectors in cortical neuro...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.10.050

    authors： Sadakane O,Masamizu Y,Watakabe A,Terada S,Ohtsuka M,Takaji M,Mizukami H,Ozawa K,Kawasaki H,Matsuzaki M,Yamamori T

    更新日期：2015-12-01 00:00:00

  • Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.

    abstract：:A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual monoallelic expression of TERT, allowing immortalization. Here, we find that DNA methylation of the TERT CpG island (CGI) is also allele-specific in multiple can...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.12.001

    authors： Stern JL,Paucek RD,Huang FW,Ghandi M,Nwumeh R,Costello JC,Cech TR

    更新日期：2017-12-26 00:00:00

  • Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing.

    abstract：:Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elusive. Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.059

    authors： Joost S,Jacob T,Sun X,Annusver K,La Manno G,Sur I,Kasper M

    更新日期：2018-10-16 00:00:00