当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Innate immune-directed NF-κB signaling requires site-specific NEMO ubiquitination.

Innate immune-directed NF-κB signaling requires site-specific NEMO ubiquitination.

Abstract：

:While the I kappa kinase (IKK) scaffolding protein NF-κB essential modulator (NEMO) binds to polyubiquitin chains to transmit inflammatory signals, NEMO itself is also ubiquitinated in response to a variety of inflammatory agonists. Although there have been hints that polyubiquitination of NEMO is essential for avoiding inflammatory disorders, the in vivo physiologic role of NEMO ubiquitination is unknown. In this work, we knock in a NEMO allele in which two major inflammatory agonist-induced ubiquitination sites cannot be ubiquitinated. We show that mice with a nonubiquitinatable NEMO allele display embryonic lethality. Heterozygous females develop inflammatory skin lesions, decreased B cell numbers, and hypercellular spleens. Embryonic lethality can be complemented by mating onto a TNFR1(-/-) background, at the cost of severe steatohepatitis and early mortality, and we also show that NEMO ubiquitination is required for optimal innate immune signaling responses. These findings suggest that NEMO ubiquitination is crucial for NF-κB activity in response to innate immune agonists.

journal_name

Cell Rep

journal_title

Cell reports

authors

Jun JC,Kertesy S,Jones MB,Marinis JM,Cobb BA,Tigno-Aranjuez JT,Abbott DW

doi

10.1016/j.celrep.2013.06.036

subject

Has Abstract

pub_date

2013-07-25 00:00:00

pages

352-61

issue

2

issn

2211-1247

pii

S2211-1247(13)00328-8

journal_volume

4

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.

    abstract：:Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precisely how these phenomena are linked, however, remains unclear. Using a cortico-hip...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107865

    authors： Agasse F,Mendez-David I,Christaller W,Carpentier R,Braz BY,David DJ,Saudou F,Humbert S

    更新日期：2020-07-07 00:00:00

  • Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.

    abstract：:At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone. In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by endocytosis. Therefore, the coupling of exo- and endocytosis is crucial. Despite...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.060

    authors： Orlando M,Schmitz D,Rosenmund C,Herman MA

    更新日期：2019-12-17 00:00:00

  • Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration.

    abstract：:We report that the mammalian 5-methylcytosine (5mC) oxidase Tet3 exists as three major isoforms and characterized the full-length isoform containing an N-terminal CXXC domain (Tet3FL). This CXXC domain binds to unmethylated CpGs, but, unexpectedly, its highest affinity is toward 5-carboxylcytosine (5caC). We determine...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.12.044

    authors： Jin SG,Zhang ZM,Dunwell TL,Harter MR,Wu X,Johnson J,Li Z,Liu J,Szabó PE,Lu Q,Xu GL,Song J,Pfeifer GP

    更新日期：2016-01-26 00:00:00

  • Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells.

    abstract：:The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distinct proteomes, microRNAs (miRNAs), and circular RNAs. Here, we comprehensively ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.054

    authors： Hinger SA,Cha DJ,Franklin JL,Higginbotham JN,Dou Y,Ping J,Shu L,Prasad N,Levy S,Zhang B,Liu Q,Weaver AM,Coffey RJ,Patton JG

    更新日期：2018-10-16 00:00:00

  • The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity.

    abstract：:Molecular processes involving lncRNAs regulate cell function. By applying transcriptomics, we identify lncRNAs whose expression is regulated by transforming growth factor β (TGF-β). Upon silencing individual lncRNAs, we identify several that regulate TGF-β signaling. Among these lncRNAs, TGFB2-antisense RNA1 (TGFB2-AS...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.08.028

    authors： Papoutsoglou P,Tsubakihara Y,Caja L,Morén A,Pallis P,Ameur A,Heldin CH,Moustakas A

    更新日期：2019-09-17 00:00:00

  • Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity.

    abstract：:Self-reactive CD4 T cells are incompletely deleted during thymic development, and their peripheral seeding highlights the need for additional safeguards to avert autoimmunity. Here, we show an essential role for the coinhibitory molecule programmed death-1 (PD-1) in silencing the activation of high-affinity autoreacti...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.10.042

    authors： Jiang TT,Martinov T,Xin L,Kinder JM,Spanier JA,Fife BT,Way SS

    更新日期：2016-11-08 00:00:00

  • Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis.

    abstract：:During bacterial sepsis, proinflammatory cytokines contribute to multiorgan failure and death in a process regulated in part by cytolytic cell granzymes. When challenged with a sublethal dose of the identified mouse pathogen Brucella microti, wild-type (WT) and granzyme A (gzmA)(-/-) mice eliminate the organism from l...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.012

    authors： Arias MA,Jiménez de Bagües MP,Aguiló N,Menao S,Hervás-Stubbs S,de Martino A,Alcaraz A,Simon MM,Froelich CJ,Pardo J

    更新日期：2014-07-24 00:00:00

  • CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.

    abstract：:Although poly(ADP-ribose) polymerase (PARP) inhibitors are active in homologous recombination (HR)-deficient cancers, their utility is limited by acquired resistance after restoration of HR. Here, we report that dinaciclib, an inhibitor of cyclin-dependent kinases (CDKs) 1, 2, 5, and 9, additionally has potent activit...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.10.077

    authors： Johnson SF,Cruz C,Greifenberg AK,Dust S,Stover DG,Chi D,Primack B,Cao S,Bernhardy AJ,Coulson R,Lazaro JB,Kochupurakkal B,Sun H,Unitt C,Moreau LA,Sarosiek KA,Scaltriti M,Juric D,Baselga J,Richardson AL,Rodig SJ,D

    更新日期：2016-11-22 00:00:00

  • Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior.

    abstract：:The neurodevelopmental origin of hyperactivity disorder has been suggested to involve the dopaminergic system, but the underlying mechanisms are still unknown. Here, transcription factors Lmx1a and Lmx1b are shown to be essential for midbrain dopaminergic (mDA) neuron excitatory synaptic inputs and dendritic developme...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.01.084

    authors： Salesse C,Charest J,Doucet-Beaupré H,Castonguay AM,Labrecque S,De Koninck P,Lévesque M

    更新日期：2020-02-18 00:00:00

  • Nucleosome assembly dynamics involve spontaneous fluctuations in the handedness of tetrasomes.

    abstract：:DNA wrapping around histone octamers generates nucleosomes, the basic compaction unit of eukaryotic chromatin. Nucleosome stability is carefully tuned to maintain DNA accessibility in transcription, replication, and repair. Using freely orbiting magnetic tweezers, which measure the twist and length of single DNA molec...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.12.022

    authors： Vlijm R,Lee M,Lipfert J,Lusser A,Dekker C,Dekker NH

    更新日期：2015-01-13 00:00:00

  • Structural Basis of the Diversity of Adrenergic Receptors.

    abstract：:Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, and understanding this diversity is key for designing selective or biased drugs for them. Here, we determine two crystal structures of the α2A adrenergic receptor (α2AAR) in complex with a partia...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.088

    authors： Qu L,Zhou Q,Xu Y,Guo Y,Chen X,Yao D,Han GW,Liu ZJ,Stevens RC,Zhong G,Wu D,Zhao S

    更新日期：2019-12-03 00:00:00

  • HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.

    abstract：:Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases. This provides the rationale for HSP90 inhibitors as cancer therapeutics. However, the mechanism by which HSP90 ATPase inhibition triggers ubiqu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.05.078

    authors： Li Z,Zhou L,Prodromou C,Savic V,Pearl LH

    更新日期：2017-06-20 00:00:00

  • Host AMPK Is a Modulator of Plasmodium Liver Infection.

    abstract：:Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here,...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.08.001

    authors： Ruivo MTG,Vera IM,Sales-Dias J,Meireles P,Gural N,Bhatia SN,Mota MM,Mancio-Silva L

    更新日期：2016-09-06 00:00:00

  • XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.

    abstract：:X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAP or deletion of its...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.05.008

    authors： Yabal M,Müller N,Adler H,Knies N,Groß CJ,Damgaard RB,Kanegane H,Ringelhan M,Kaufmann T,Heikenwälder M,Strasser A,Groß O,Ruland J,Peschel C,Gyrd-Hansen M,Jost PJ

    更新日期：2014-06-26 00:00:00

  • Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum.

    abstract：:The corpus callosum is the major axon tract that connects and integrates neural activity between the two cerebral hemispheres. Although ∼1:4,000 children are born with developmental absence of the corpus callosum, the primary etiology of this condition remains unknown. Here, we demonstrate that midline crossing of cal...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.09.033

    authors： Gobius I,Morcom L,Suárez R,Bunt J,Bukshpun P,Reardon W,Dobyns WB,Rubenstein JL,Barkovich AJ,Sherr EH,Richards LJ

    更新日期：2016-10-11 00:00:00

  • TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.

    abstract：:The ten-eleven-translocation 5-methylcytosine dioxygenase (TET) family of enzymes catalyzes the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), a modified cytosine base that facilitates gene expression. Cells respond to hypoxia by inducing a transcriptional program regulated in part by oxygen...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.04.040

    authors： Mariani CJ,Vasanthakumar A,Madzo J,Yesilkanal A,Bhagat T,Yu Y,Bhattacharyya S,Wenger RH,Cohn SL,Nanduri J,Verma A,Prabhakar NR,Godley LA

    更新日期：2014-06-12 00:00:00

  • Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex.

    abstract：:In contrast to our extensive knowledge on covalent small ubiquitin-like modifier (SUMO) target proteins, we are limited in our understanding of non-covalent SUMO-binding proteins. We identify interactors of different SUMO isoforms-monomeric SUMO1, monomeric SUMO2, or linear trimeric SUMO2 chains-using a mass spectrome...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2021.108691

    authors： González-Prieto R,Eifler-Olivi K,Claessens LA,Willemstein E,Xiao Z,Talavera Ormeno CMP,Ovaa H,Ulrich HD,Vertegaal ACO

    更新日期：2021-01-26 00:00:00

  • Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation.

    abstract：:Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108088

    authors： Cheung CS,Fruehwirth A,Paparoditis PCG,Shen CH,Foglierini M,Joyce MG,Leung K,Piccoli L,Rawi R,Silacci-Fregni C,Tsybovsky Y,Verardi R,Wang L,Wang S,Yang ES,Zhang B,Zhang Y,Chuang GY,Corti D,Mascola JR,Shapiro L,K

    更新日期：2020-09-01 00:00:00

  • Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter.

    abstract：:Cell proliferation changes concomitantly with fate transitions during reprogramming, differentiation, regeneration, and oncogenesis. Methods to resolve cell cycle length heterogeneity in real time are currently lacking. Here, we describe a genetically encoded fluorescent reporter that captures live-cell cycle speed us...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107804

    authors： Eastman AE,Chen X,Hu X,Hartman AA,Pearlman Morales AM,Yang C,Lu J,Kueh HY,Guo S

    更新日期：2020-06-23 00:00:00

  • A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology.

    abstract：:We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, includ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.12.041

    authors： Matarin M,Salih DA,Yasvoina M,Cummings DM,Guelfi S,Liu W,Nahaboo Solim MA,Moens TG,Paublete RM,Ali SS,Perona M,Desai R,Smith KJ,Latcham J,Fulleylove M,Richardson JC,Hardy J,Edwards FA

    更新日期：2015-02-03 00:00:00

  • Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma.

    abstract：:Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC), frequent activation of HIF signaling induces a metabolic switch that promotes tumorigenesis. Here, we demonstrate that PGC...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.06.006

    authors： LaGory EL,Wu C,Taniguchi CM,Ding CC,Chi JT,von Eyben R,Scott DA,Richardson AD,Giaccia AJ

    更新日期：2015-07-07 00:00:00

  • Lineage-Specific and Non-specific Cytokine-Sensing Genes Respond Differentially to the Master Regulator STAT5.

    abstract：:STAT5, a member of the family of signal transducers and activators of transcription, senses cytokines and controls the biology of cell lineages, including mammary, liver, and T cells. Here, we show that STAT5 activates lineage-specific and widely expressed genes through different mechanisms. STAT5 preferentially binds...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.11.079

    authors： Zeng X,Willi M,Shin HY,Hennighausen L,Wang C

    更新日期：2016-12-20 00:00:00

  • Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease.

    abstract：:The architecture of renal glomeruli is acquired through intricate and still poorly understood developmental steps. In our study we identify a crucial glomerular morphogenetic event in nephrogenesis that drives the remodeling/separation of the prospective vascular pole (the future entrance of the glomerular arterioles)...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108304

    authors： Fiorentino A,Christophorou A,Massa F,Garbay S,Chiral M,Ramsing M,Rasmussen M,Gubler MC,Bessieres B,Heidet L,Fischer E,Pontoglio M

    更新日期：2020-10-27 00:00:00

  • Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1.

    abstract：:Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.10.063

    authors： Nersesyan Y,Demirkhanyan L,Cabezas-Bratesco D,Oakes V,Kusuda R,Dawson T,Sun X,Cao C,Cohen AM,Chelluboina B,Veeravalli KK,Zimmermann K,Domene C,Brauchi S,Zakharian E

    更新日期：2017-11-07 00:00:00

  • Protein Expression Landscape of Mouse Embryos during Pre-implantation Development.

    abstract：:Pre-implantation embryo development is an intricate and precisely regulated process orchestrated by maternally inherited proteins and newly synthesized proteins following zygotic genome activation. Although genomic and transcriptomic studies have enriched our understanding of the genetic programs underlying this proce...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.11.111

    authors： Gao Y,Liu X,Tang B,Li C,Kou Z,Li L,Liu W,Wu Y,Kou X,Li J,Zhao Y,Yin J,Wang H,Chen S,Liao L,Gao S

    更新日期：2017-12-26 00:00:00

  • Visual Input into the Drosophila melanogaster Mushroom Body.

    abstract：:The patterns of neuronal connectivity underlying multisensory integration, a fundamental property of many brains, remain poorly characterized. The Drosophila melanogaster mushroom body-an associative center-is an ideal system to investigate how different sensory channels converge in higher order brain centers. The neu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108138

    authors： Li J,Mahoney BD,Jacob MS,Caron SJC

    更新日期：2020-09-15 00:00:00

  • LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.

    abstract：:Here, we ask how neural stem cells (NSCs) transition in the developing neocortex from a rapidly to a slowly proliferating state, a process required to maintain lifelong stem cell pools. We identify LRIG1, known to regulate receptor tyrosine kinase signaling in other cell types, as a negative regulator of cortical NSC ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108257

    authors： Jeong D,Lozano Casasbuenas D,Gengatharan A,Edwards K,Saghatelyan A,Kaplan DR,Miller FD,Yuzwa SA

    更新日期：2020-10-13 00:00:00

  • Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.

    abstract：:Endosomal sorting complexes required for transport (ESCRT) drive cell surface receptor degradation resulting in attenuation of oncogenic signaling and pointing to a tumor suppressor function. Here, we show that loss of function of an ESCRT protein (HD-PTP encoded by the PTPN23 gene, located on the tumor suppressor gen...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.04.076

    authors： Manteghi S,Gingras MC,Kharitidi D,Galarneau L,Marques M,Yan M,Cencic R,Robert F,Paquet M,Witcher M,Pelletier J,Pause A

    更新日期：2016-05-31 00:00:00

  • Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation.

    abstract：:Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human (HeLa) cells, and ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.07.024

    authors： Weinert BT,Schölz C,Wagner SA,Iesmantavicius V,Su D,Daniel JA,Choudhary C

    更新日期：2013-08-29 00:00:00

  • Paracrine apoptotic effect of p53 mediated by tumor suppressor Par-4.

    abstract：:The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apopt...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.12.020

    authors： Burikhanov R,Shrestha-Bhattarai T,Hebbar N,Qiu S,Zhao Y,Zambetti GP,Rangnekar VM

    更新日期：2014-01-30 00:00:00