Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells.

abstract：:The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more responsive than are binucleated cardiomyocytes to pro-proliferative stimuli. We...

journal_title：Cell reports

authors： Windmueller R,Leach JP,Babu A,Zhou S,Morley MP,Wakabayashi A,Petrenko NB,Viatour P,Morrisey EE

更新日期：2020-03-03 00:00:00

abstract：:Mutations of WD40-repeat protein 62 (WDR62) have been identified recently to cause human MCPH (autosomal-recessive primary microcephaly), a neurodevelopmental disorder characterized by decreased brain size. However, the underlying mechanism is unclear. Here, we investigate the function of WDR62 in brain development an...

journal_title：Cell reports

authors： Xu D,Zhang F,Wang Y,Sun Y,Xu Z

更新日期：2014-01-16 00:00:00

abstract：:Dicistrovirus intergenic region internal ribosomal entry sites (IGR IRESs) do not require initiator tRNA, an AUG codon, or initiation factors and jumpstart translation from the middle of the elongation cycle via formation of IRES/80S complexes resembling the pre-translocation state. eEF2 then translocates the [codon-a...

journal_title：Cell reports

authors： Abaeva IS,Vicens Q,Bochler A,Soufari H,Simonetti A,Pestova TV,Hashem Y,Hellen CUT

更新日期：2020-12-08 00:00:00

abstract：:Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibr...

journal_title：Cell reports

authors： Vila IK,Badin PM,Marques MA,Monbrun L,Lefort C,Mir L,Louche K,Bourlier V,Roussel B,Gui P,Grober J,Štich V,Rossmeislová L,Zakaroff-Girard A,Bouloumié A,Viguerie N,Moro C,Tavernier G,Langin D

更新日期：2014-05-22 00:00:00

abstract：:In humans, Vγ9Vδ2 T cells respond to self and pathogen-associated, diphosphate-containing isoprenoids, also known as phosphoantigens (pAgs). However, activation and homeostasis of Vγ9Vδ2 T cells remain incompletely understood. Here, we show that pAgs induced expression of the ecto-ATPase CD39, which, however, not only...

journal_title：Cell reports

authors： Gruenbacher G,Gander H,Rahm A,Idzko M,Nussbaumer O,Thurnher M

更新日期：2016-07-12 00:00:00

abstract：:Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requisite for the respons...

journal_title：Cell reports

authors： Wei T,Najmi SM,Liu H,Peltonen K,Kucerova A,Schneider DA,Laiho M

更新日期：2018-04-10 00:00:00

abstract：:In the presynaptic terminal, the magnitude and location of Ca2+ entry through voltage-gated Ca2+ channels (VGCCs) regulate the efficacy of neurotransmitter release. However, how presynaptic active zone proteins control mammalian VGCC levels and organization is unclear. To address this, we deleted the CAST/ELKS protein...

journal_title：Cell reports

authors： Dong W,Radulovic T,Goral RO,Thomas C,Suarez Montesinos M,Guerrero-Given D,Hagiwara A,Putzke T,Hida Y,Abe M,Sakimura K,Kamasawa N,Ohtsuka T,Young SM Jr

更新日期：2018-07-10 00:00:00

abstract：:The p110β isoform of PI3K is preferentially activated in many tumors deficient in the phosphatase and tensin homolog (PTEN). However, the mechanism(s) linking PTEN loss to p110β activation remain(s) mysterious. Here, we identify CRKL as a member of the class of PI3Kβ-interacting proteins. Silencing CRKL expression in ...

journal_title：Cell reports

authors： Zhang J,Gao X,Schmit F,Adelmant G,Eck MJ,Marto JA,Zhao JJ,Roberts TM

更新日期：2017-07-18 00:00:00

abstract：:Most tumor cells exhibit obligatory demands for essential amino acids (EAAs), but the regulatory mechanisms whereby tumor cells take up EAAs and EAAs promote malignant transformation remain to be determined. Here, we show that oncogenic MYC, solute carrier family (SLC) 7 member 5 (SLC7A5), and SLC43A1 constitute a fee...

journal_title：Cell reports

authors： Yue M,Jiang J,Gao P,Liu H,Qing G

更新日期：2017-12-26 00:00:00

abstract：:Obesity modifies T cell populations in adipose tissue, thereby contributing to adipose tissue inflammation and insulin resistance. Here, we show that Rab4b, a small GTPase governing endocytic trafficking, is pivotal in T cells for the development of these pathological events. Rab4b expression is decreased in adipose T...

journal_title：Cell reports

authors： Gilleron J,Bouget G,Ivanov S,Meziat C,Ceppo F,Vergoni B,Djedaini M,Soprani A,Dumas K,Jacquel A,Yvan-Charvet L,Venteclef N,Tanti JF,Cormont M

更新日期：2018-12-18 00:00:00

abstract：:Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) an...

journal_title：Cell reports

authors： Brägelmann J,Dammert MA,Dietlein F,Heuckmann JM,Choidas A,Böhm S,Richters A,Basu D,Tischler V,Lorenz C,Habenberger P,Fang Z,Ortiz-Cuaran S,Leenders F,Eickhoff J,Koch U,Getlik M,Termathe M,Sallouh M,Greff Z,Varga Z

更新日期：2017-09-19 00:00:00

abstract：:Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elusive. Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair...

journal_title：Cell reports

authors： Joost S,Jacob T,Sun X,Annusver K,La Manno G,Sur I,Kasper M

更新日期：2018-10-16 00:00:00

abstract：:The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of NAFLD. We found that cdk4 protein levels are elevated in mouse models of NAFLD and in patients with fatty livers. This increase leads to C/EBPα phosphorylation on S...

journal_title：Cell reports

authors： Jin J,Valanejad L,Nguyen TP,Lewis K,Wright M,Cast A,Stock L,Timchenko L,Timchenko NA

更新日期：2016-07-19 00:00:00

abstract：:Most current tumor immunotherapy strategies leverage cytotoxic CD8+ T cells. Despite evidence for clinical potential of CD4+ tumor-infiltrating lymphocytes (TILs), their functional diversity limits our ability to harness their activity. Here, we use single-cell mRNA sequencing to analyze the response of tumor-specific...

journal_title：Cell reports

authors： Magen A,Nie J,Ciucci T,Tamoutounour S,Zhao Y,Mehta M,Tran B,McGavern DB,Hannenhalli S,Bosselut R

更新日期：2019-12-03 00:00:00

abstract：:Current treatment regimens for pancreatic ductal adenocarcinoma (PDAC) yield poor 5-year survival, emphasizing the critical need to identify druggable targets essential for PDAC maintenance. We developed an unbiased and in vivo target discovery approach to identify molecular vulnerabilities in low-passage and patient-...

journal_title：Cell reports

authors： Carugo A,Genovese G,Seth S,Nezi L,Rose JL,Bossi D,Cicalese A,Shah PK,Viale A,Pettazzoni PF,Akdemir KC,Bristow CA,Robinson FS,Tepper J,Sanchez N,Gupta S,Estecio MR,Giuliani V,Dellino GI,Riva L,Yao W,Di Francesco

更新日期：2016-06-28 00:00:00

abstract：:PARP1 plays a critical role in regulating many biological processes linked to cellular stress responses. Although DNA strand breaks are potent stimuli of PARP1 enzymatic activity, the context-dependent mechanism regulating PARP1 activation and signaling is poorly understood. We performed global characterization of the...

journal_title：Cell reports

authors： Zhen Y,Zhang Y,Yu Y

更新日期：2017-11-21 00:00:00

abstract：:Selecting a suitable site to deposit their eggs is an important reproductive need of Drosophila females. Although their choosiness toward egg-laying sites is well documented, the specific neural mechanism that activates females' search for attractive egg-laying sites is not known. Here, we show that distention and con...

journal_title：Cell reports

authors： Gou B,Liu Y,Guntur AR,Stern U,Yang CH

更新日期：2014-10-23 00:00:00

abstract：:Antibodies secreted within the intestinal tract provide protection from the invasion of microbes into the host tissues. Germinal center (GC) formation in lymph nodes and spleen strictly requires SLAM-associated protein (SAP)-mediated T cell functions; however, it is not known whether this mechanism plays a similar rol...

journal_title：Cell reports

authors： Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z

更新日期：2020-02-11 00:00:00

abstract：:Wnts are a family of 19 extracellular ligands that regulate cell fate, proliferation, and migration during metazoan embryogenesis and throughout adulthood. Wnts are acylated post-translationally at a conserved serine and bind the extracellular cysteine-rich domain (CRD) of Frizzled (FZD) seven-pass transmembrane recep...

journal_title：Cell reports

authors： Speer KF,Sommer A,Tajer B,Mullins MC,Klein PS,Lemmon MA

更新日期：2019-01-22 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are critical regulators of the cellular response to hypoxia. Despite their established roles in normal physiology and numerous pathologies, the molecular mechanisms by which they control gene expression remain poorly understood. We report here a conserved role for the TIP60 complex as ...

journal_title：Cell reports

authors： Perez-Perri JI,Dengler VL,Audetat KA,Pandey A,Bonner EA,Urh M,Mendez J,Daniels DL,Wappner P,Galbraith MD,Espinosa JM

更新日期：2016-06-28 00:00:00

abstract：:During chronic infection, the inflammatory cytokine interferon gamma (IFNγ) damages hematopoietic stem cells (HSCs) by disrupting quiescence and promoting excessive terminal differentiation. However, the mechanism by which IFNγ hinders HSC quiescence remains undefined. Using intravital 3-dimensional microscopy, we fin...

journal_title：Cell reports

authors： Florez MA,Matatall KA,Jeong Y,Ortinau L,Shafer PW,Lynch AM,Jaksik R,Kimmel M,Park D,King KY

更新日期：2020-12-22 00:00:00

abstract：:The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression. However, it remains unclear whether these two degrees of H3K27 methylation have di...

journal_title：Cell reports

authors： Juan AH,Wang S,Ko KD,Zare H,Tsai PF,Feng X,Vivanco KO,Ascoli AM,Gutierrez-Cruz G,Krebs J,Sidoli S,Knight AL,Pedersen RA,Garcia BA,Casellas R,Zou J,Sartorelli V

更新日期：2016-10-25 00:00:00

abstract：:In higher vertebrates, cephalic neural crest cells (NCCs) form craniofacial skeleton by differentiating into chondrocytes and osteoblasts. A subpopulation of cephalic NCCs, cardiac NCCs (CNCCs), migrates to the heart. However, CNCCs mostly do not yield skeletogenic derivatives, and the molecular mechanisms of this fat...

journal_title：Cell reports

authors： Arai HN,Sato F,Yamamoto T,Woltjen K,Kiyonari H,Yoshimoto Y,Shukunami C,Akiyama H,Kist R,Sehara-Fujisawa A

更新日期：2019-10-15 00:00:00

abstract：:The patterns of neuronal connectivity underlying multisensory integration, a fundamental property of many brains, remain poorly characterized. The Drosophila melanogaster mushroom body-an associative center-is an ideal system to investigate how different sensory channels converge in higher order brain centers. The neu...

journal_title：Cell reports

authors： Li J,Mahoney BD,Jacob MS,Caron SJC

更新日期：2020-09-15 00:00:00

abstract：:Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3' UTR, preserves ERAP1 from miR-UL112-5p-mediated degradation. Specific...

journal_title：Cell reports

authors： Romania P,Cifaldi L,Pignoloni B,Starc N,D'Alicandro V,Melaiu O,Li Pira G,Giorda E,Carrozzo R,Bergvall M,Bergström T,Alfredsson L,Olsson T,Kockum I,Seppälä I,Lehtimäki T,Hurme MA,Hengel H,Santoni A,Cerboni C,Locate

更新日期：2017-07-25 00:00:00

abstract：:Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of infection remains incomplete. Here, we ...

journal_title：Cell reports

authors： Glennon EKK,Austin LS,Arang N,Kain HS,Mast FD,Vijayan K,Aitchison JD,Kappe SHI,Kaushansky A

更新日期：2019-03-19 00:00:00

abstract：:Innate immunity is central to the pathophysiology of neurodegenerative disorders, but it remains unclear why immunity is altered in the disease state and whether changes in immunity are a cause or a consequence of neuronal dysfunction. Here, we identify a molecular pathway that links innate immunity to age-dependent l...

journal_title：Cell reports

authors： Shukla AK,Spurrier J,Kuzina I,Giniger E

更新日期：2019-01-02 00:00:00

abstract：:Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and neurodegeneration in mice. Transcriptional analysis of endophilin-A mutant mi...

journal_title：Cell reports

authors： Murdoch JD,Rostosky CM,Gowrisankaran S,Arora AS,Soukup SF,Vidal R,Capece V,Freytag S,Fischer A,Verstreken P,Bonn S,Raimundo N,Milosevic I

更新日期：2016-10-18 00:00:00

abstract：:Stable unannotated transcripts (SUTs), some of which overlap protein-coding genes in antisense direction, are a class of non-coding RNAs. While case studies have reported important regulatory roles for several of such RNAs, their general impact on protein abundance regulation of the overlapping gene is not known. To t...

journal_title：Cell reports

authors： Huber F,Bunina D,Gupta I,Khmelinskii A,Meurer M,Theer P,Steinmetz LM,Knop M

更新日期：2016-06-21 00:00:00

abstract：:Chemogenetics enables manipulation of neuronal activity in experimental animals. While providing information about the transduced neuron expressing a ligand-activated molecule, chemogenetics does not provide understanding about the antecedent circuit that drives that neuron's activity. For current approaches, this is ...

journal_title：Cell reports

authors： Ngo HB,Melo MR,Layfield S,Connelly AA,Bassi JK,Xie L,Menuet C,McDougall SJ,Bathgate RAD,Allen AM

更新日期：2020-09-15 00:00:00