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The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.

Abstract：

:Dicistrovirus intergenic region internal ribosomal entry sites (IGR IRESs) do not require initiator tRNA, an AUG codon, or initiation factors and jumpstart translation from the middle of the elongation cycle via formation of IRES/80S complexes resembling the pre-translocation state. eEF2 then translocates the [codon-anticodon]-mimicking pseudoknot I (PKI) from ribosomal A sites to P sites, bringing the first sense codon into the decoding center. Halastavi árva virus (HalV) contains an IGR that is related to previously described IGR IRESs but lacks domain 2, which enables these IRESs to bind to individual 40S ribosomal subunits. By using in vitro reconstitution and cryoelectron microscopy (cryo-EM), we now report that the HalV IGR IRES functions by the simplest initiation mechanism that involves binding to 80S ribosomes such that PKI is placed in the P site, so that the A site contains the first codon that is directly accessible for decoding without prior eEF2-mediated translocation of PKI.

journal_name

Cell Rep

journal_title

Cell reports

authors

Abaeva IS,Vicens Q,Bochler A,Soufari H,Simonetti A,Pestova TV,Hashem Y,Hellen CUT

doi

10.1016/j.celrep.2020.108476

subject

Has Abstract

pub_date

2020-12-08 00:00:00

pages

108476

issue

10

issn

2211-1247

pii

S2211-1247(20)31465-0

journal_volume

33

pub_type

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