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Local Resting Ca2+ Controls the Scale of Astroglial Ca2+ Signals.

Abstract：

:Astroglia regulate neurovascular coupling while engaging in signal exchange with neurons. The underlying cellular machinery is thought to rely on astrocytic Ca2+ signals, but what controls their amplitude and waveform is poorly understood. Here, we employ time-resolved two-photon excitation fluorescence imaging in acute hippocampal slices and in cortex in vivo to find that resting [Ca2+] predicts the scale (amplitude) and the maximum (peak) of astroglial Ca2+ elevations. We bidirectionally manipulate resting [Ca2+] by uncaging intracellular Ca2+ or Ca2+ buffers and use ratiometric imaging of a genetically encoded Ca2+ indicator to establish that alterations in resting [Ca2+] change co-directionally the peak level and anti-directionally the amplitude of local Ca2+ transients. This relationship holds for spontaneous and for induced (for instance by locomotion) Ca2+ signals. Our findings uncover a basic generic rule of Ca2+ signal formation in astrocytes, thus also associating the resting Ca2+ level with the physiological "excitability" state of astroglia.

journal_name

Cell Rep

journal_title

Cell reports

authors

King CM,Bohmbach K,Minge D,Delekate A,Zheng K,Reynolds J,Rakers C,Zeug A,Petzold GC,Rusakov DA,Henneberger C

doi

10.1016/j.celrep.2020.02.043

subject

Has Abstract

pub_date

2020-03-10 00:00:00

pages

3466-3477.e4

issue

10

issn

2211-1247

pii

S2211-1247(20)30204-7

journal_volume

30

pub_type

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