TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.

abstract：:The local synthesis of transmembrane proteins underlies functional specialization of dendritic microdomains in neuronal plasticity. It is unclear whether these proteins have access to the complete machinery of the secretory pathway following local synthesis. In this study, we describe a probe called pGolt that allows ...

journal_title：Cell reports

authors： Mikhaylova M,Bera S,Kobler O,Frischknecht R,Kreutz MR

更新日期：2016-01-12 00:00:00

abstract：:In glioblastoma, invasion and proliferation are presumed to be mutually exclusive events; however, the molecular mechanisms that mediate this switch at the cellular level remain elusive. Previously, we have shown that phospho-OLIG2, a central-nervous-system-specific transcription factor, is essential for tumor growth ...

journal_title：Cell reports

authors： Singh SK,Fiorelli R,Kupp R,Rajan S,Szeto E,Lo Cascio C,Maire CL,Sun Y,Alberta JA,Eschbacher JM,Ligon KL,Berens ME,Sanai N,Mehta S

更新日期：2016-07-26 00:00:00

abstract：:The efficient generation of hematopoietic stem cells from human pluripotent stem cells is dependent on the appropriate specification of the definitive hematopoietic program during differentiation. In this study, we used T lymphocyte potential to track the onset of definitive hematopoiesis from human embryonic and indu...

journal_title：Cell reports

authors： Kennedy M,Awong G,Sturgeon CM,Ditadi A,LaMotte-Mohs R,Zúñiga-Pflücker JC,Keller G

更新日期：2012-12-27 00:00:00

abstract：:Durable humoral immunity against epidemic infectious disease requires the survival of long-lived plasma cells (LLPCs). LLPC longevity is dependent on metabolic programs distinct from short-lived plasma cells (SLPCs); however, the mechanistic basis for this difference is unclear. We have previously shown that CD28, the...

journal_title：Cell reports

authors： Utley A,Chavel C,Lightman S,Holling GA,Cooper J,Peng P,Liu W,Barwick BG,Gavile CM,Maguire O,Murray-Dupuis M,Rozanski C,Jordan MS,Kambayashi T,Olejniczak SH,Boise LH,Lee KP

更新日期：2020-06-23 00:00:00

abstract：:Billions of cells undergo apoptosis daily and often fragment into small, membrane-bound extracellular vesicles termed apoptotic bodies (ApoBDs). We demonstrate that apoptotic monocytes undergo a highly coordinated disassembly process and form long, beaded protrusions (coined as beaded apoptopodia), which fragment to r...

journal_title：Cell reports

authors： Atkin-Smith GK,Miles MA,Tixeira R,Lay FT,Duan M,Hawkins CJ,Phan TK,Paone S,Mathivanan S,Hulett MD,Chen W,Poon IKH

更新日期：2019-11-12 00:00:00

abstract：:In the presynaptic terminal, the magnitude and location of Ca2+ entry through voltage-gated Ca2+ channels (VGCCs) regulate the efficacy of neurotransmitter release. However, how presynaptic active zone proteins control mammalian VGCC levels and organization is unclear. To address this, we deleted the CAST/ELKS protein...

journal_title：Cell reports

authors： Dong W,Radulovic T,Goral RO,Thomas C,Suarez Montesinos M,Guerrero-Given D,Hagiwara A,Putzke T,Hida Y,Abe M,Sakimura K,Kamasawa N,Ohtsuka T,Young SM Jr

更新日期：2018-07-10 00:00:00

abstract：:During cell division, the molecular motor Eg5 crosslinks overlapping antiparallel microtubules and pushes them apart to separate mitotic spindle poles. Dynein has been proposed as a direct antagonist of Eg5 at the spindle equator, pulling on antiparallel microtubules and favoring spindle collapse. Some of the experime...

journal_title：Cell reports

authors： Florian S,Mayer TU

更新日期：2012-05-31 00:00:00

abstract：:Stable wakefulness requires orexin/hypocretin neurons (OHNs) and OHR2 receptors. OHNs sense diverse environmental cues and control arousal accordingly. For unknown reasons, OHNs contain multiple excitatory transmitters, including OH peptides and glutamate. To analyze their cotransmission within computational framework...

journal_title：Cell reports

authors： Schöne C,Apergis-Schoute J,Sakurai T,Adamantidis A,Burdakov D

更新日期：2014-05-08 00:00:00

abstract：:Tight-junction-regulated actomyosin activity determines epithelial and endothelial tension on adherens junctions and drives morphogenetic processes; however, whether or not tight junctions themselves are under tensile stress is not clear. Here, we use a tension sensor based on ZO-1, a scaffolding protein that links th...

journal_title：Cell reports

authors： Haas AJ,Zihni C,Ruppel A,Hartmann C,Ebnet K,Tada M,Balda MS,Matter K

更新日期：2020-07-21 00:00:00

abstract：:Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of infection remains incomplete. Here, we ...

journal_title：Cell reports

authors： Glennon EKK,Austin LS,Arang N,Kain HS,Mast FD,Vijayan K,Aitchison JD,Kappe SHI,Kaushansky A

更新日期：2019-03-19 00:00:00

abstract：:The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or active regulators of the process. We show...

journal_title：Cell reports

authors： Laflamme G,Sim S,Leary A,Pascariu M,Vogel J,D'Amours D

更新日期：2019-03-12 00:00:00

abstract：:Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on the virus and their immunogenicity are poorly understood. Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocap...

journal_title：Cell reports

authors： Lu S,Xie XX,Zhao L,Wang B,Zhu J,Yang TR,Yang GW,Ji M,Lv CP,Xue J,Dai EH,Fu XM,Liu DQ,Zhang L,Hou SJ,Yu XL,Wang YL,Gao HX,Shi XH,Ke CW,Ke BX,Jiang CG,Liu RT

更新日期：2021-01-26 00:00:00

abstract：:Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among the most common gastrointestinal disorders. Inflamed tissues frequently experience conditions of insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia and consequent stabilization of the hypoxia-inducible factor ...

journal_title：Cell reports

authors： Lee KE,Spata M,Maduka R,Vonderheide RH,Simon MC

更新日期：2018-06-19 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) confer health benefits by preventing inflammation and obesity and by increasing thermogenesis in brown and beige adipocytes. As well as being supplied exogenously as nutrients, PUFAs are largely stored in membrane glycerophospholipids and released by phospholipase A2s (PLA2s). Howev...

journal_title：Cell reports

authors： Sato H,Taketomi Y,Miki Y,Murase R,Yamamoto K,Murakami M

更新日期：2020-05-05 00:00:00

abstract：:RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors (HDFs). While informative, these early studies overlap poorly due to false positives and false negatives. To ameliorate these issues, we combined information from the existing HDF screens together with new screens performed with multipl...

journal_title：Cell reports

authors： Zhu J,Davoli T,Perriera JM,Chin CR,Gaiha GD,John SP,Sigiollot FD,Gao G,Xu Q,Qu H,Pertel T,Sims JS,Smith JA,Baker RE,Maranda L,Ng A,Elledge SJ,Brass AL

更新日期：2014-10-23 00:00:00

abstract：:Presynaptic endosomes reportedly participate in synaptic vesicle (SV) recycling. However, it remains unclear whether they differentially regulate SV biogenesis and synaptic transmission in different types of synapses and how they are implicated in diseases. Using cryo-electron tomography and endocytic tracing, we unco...

journal_title：Cell reports

authors： Li X,Qin L,Li Y,Yu H,Zhang Z,Tao C,Liu Y,Xue Y,Zhang X,Xu Z,Wang Y,Lou H,Tan Z,Saftig P,Chen Z,Xu T,Bi G,Duan S,Gao Z

更新日期：2019-07-23 00:00:00

abstract：:Early infantile epileptic encephalopathies (EOEE) are a debilitating spectrum of disorders associated with cognitive impairments. We present a clinical report of a KCNT2 mutation in an EOEE patient. The de novo heterozygous variant Phe240Leu SLICK was identified by exome sequencing and confirmed by Sanger sequencing. ...

journal_title：Cell reports

authors： Gururaj S,Palmer EE,Sheehan GD,Kandula T,Macintosh R,Ying K,Morris P,Tao J,Dias KR,Zhu Y,Dinger ME,Cowley MJ,Kirk EP,Roscioli T,Sachdev R,Duffey ME,Bye A,Bhattacharjee A

更新日期：2017-10-24 00:00:00

abstract：:Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media in which injecte...

journal_title：Cell reports

authors： Kang Y,Ai Z,Duan K,Si C,Wang Y,Zheng Y,He J,Yin Y,Zhao S,Niu B,Zhu X,Liu L,Xiang L,Zhang L,Niu Y,Ji W,Li T

更新日期：2018-11-27 00:00:00

abstract：:Salivary proteins are essential for maintaining health in the oral cavity and proximal digestive tract, and they serve as potential diagnostic markers for monitoring human health and disease. However, their precise organ origins remain unclear. Through transcriptomic analysis of major adult and fetal salivary glands a...

journal_title：Cell reports

authors： Saitou M,Gaylord EA,Xu E,May AJ,Neznanova L,Nathan S,Grawe A,Chang J,Ryan W,Ruhl S,Knox SM,Gokcumen O

更新日期：2020-11-17 00:00:00

abstract：:The transmission of malaria parasites to mosquitoes relies on the rapid induction of sexual reproduction upon their ingestion into a blood meal. Haploid female and male gametocytes become activated and emerge from their host cells, and the males enter the cell cycle to produce eight microgametes. The synchronized natu...

journal_title：Cell reports

authors： Invergo BM,Brochet M,Yu L,Choudhary J,Beltrao P,Billker O

更新日期：2017-11-14 00:00:00

abstract：:Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates RB and functions as a collaborative nuclear oncogene. The serine threonine kinase Akt plays a pivotal role in the control of cellular metabolism, survival, and mitogenic signaling. Herein, Akt1-mediated phosphorylation of downstream substrate...

journal_title：Cell reports

authors： Chen K,Jiao X,Di Rocco A,Shen D,Xu S,Ertel A,Yu Z,Di Sante G,Wang M,Li Z,Pestell TG,Casimiro MC,Skordalakes E,Achilefu S,Pestell RG

更新日期：2020-09-15 00:00:00

abstract：:Transgenic zebrafish embryos expressing tissue-specific green fluorescent protein (GFP) can provide an unlimited supply of primary embryonic cells. Agents that promote the differentiation of these cells may be beneficial for therapeutics. We report a high-throughput approach for screening small molecules that regulate...

journal_title：Cell reports

authors： Huang H,Lindgren A,Wu X,Liu NA,Lin S

更新日期：2012-09-27 00:00:00

abstract：:CD4 and CD8 T cells play a pivotal role in controlling tumor growth. However, the interplay of both cell types and their role in tumor suppression still remain elusive. In this study, we investigated the regulation of CD4 and CD8 T cell responses to different classes of tumor-specific antigens in liver cancer mouse mo...

journal_title：Cell reports

authors： Knocke S,Fleischmann-Mundt B,Saborowski M,Manns MP,Kühnel F,Wirth TC,Woller N

更新日期：2016-11-22 00:00:00

abstract：:Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and i...

journal_title：Cell reports

authors： Dobrowolski R,Vick P,Ploper D,Gumper I,Snitkin H,Sabatini DD,De Robertis EM

更新日期：2012-11-29 00:00:00

abstract：:Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in regulating the actomyosin network by suppressing Rho GTPase in medaka fish. Here, we identify Rho GTPase activating protein 29 (ARHGAP29) as a transc...

journal_title：Cell reports

authors： Qiao Y,Chen J,Lim YB,Finch-Edmondson ML,Seshachalam VP,Qin L,Jiang T,Low BC,Singh H,Lim CT,Sudol M

更新日期：2017-05-23 00:00:00

abstract：:Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, while the colon of Rnf5-/- mice exhibits activated dendritic cells and intrinsic ...

journal_title：Cell reports

authors： Fujita Y,Khateb A,Li Y,Tinoco R,Zhang T,Bar-Yoseph H,Tam MA,Chowers Y,Sabo E,Gerassy-Vainberg S,Starosvetsky E,James B,Brown K,Shen-Orr SS,Bradley LM,Tessier PA,Ronai ZA

更新日期：2018-09-18 00:00:00

abstract：:We recently reported an autosomal dominant form of renal Fanconi syndrome caused by a missense mutation in the third codon of the peroxisomal protein EHHADH. The mutation mistargets EHHADH to mitochondria, thereby impairing mitochondrial energy production and, consequently, reabsorption of electrolytes and low-molecul...

journal_title：Cell reports

authors： Assmann N,Dettmer K,Simbuerger JMB,Broeker C,Nuernberger N,Renner K,Courtneidge H,Klootwijk ED,Duerkop A,Hall A,Kleta R,Oefner PJ,Reichold M,Reinders J

更新日期：2016-05-17 00:00:00

abstract：:Understanding how peptide selection is controlled on different major histocompatibility complex class I (MHC I) molecules is pivotal for determining how variations in these proteins influence our predisposition to infectious diseases, cancer, and autoinflammatory conditions. Although the intracellular chaperone TAPBPR...

journal_title：Cell reports

authors： Ilca FT,Drexhage LZ,Brewin G,Peacock S,Boyle LH

更新日期：2019-11-05 00:00:00

abstract：:Cell proliferation changes concomitantly with fate transitions during reprogramming, differentiation, regeneration, and oncogenesis. Methods to resolve cell cycle length heterogeneity in real time are currently lacking. Here, we describe a genetically encoded fluorescent reporter that captures live-cell cycle speed us...

journal_title：Cell reports

authors： Eastman AE,Chen X,Hu X,Hartman AA,Pearlman Morales AM,Yang C,Lu J,Kueh HY,Guo S

更新日期：2020-06-23 00:00:00

abstract：:Astroglia regulate neurovascular coupling while engaging in signal exchange with neurons. The underlying cellular machinery is thought to rely on astrocytic Ca2+ signals, but what controls their amplitude and waveform is poorly understood. Here, we employ time-resolved two-photon excitation fluorescence imaging in acu...

journal_title：Cell reports

authors： King CM,Bohmbach K,Minge D,Delekate A,Zheng K,Reynolds J,Rakers C,Zeug A,Petzold GC,Rusakov DA,Henneberger C

更新日期：2020-03-10 00:00:00