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Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly.

Abstract：

:Billions of cells undergo apoptosis daily and often fragment into small, membrane-bound extracellular vesicles termed apoptotic bodies (ApoBDs). We demonstrate that apoptotic monocytes undergo a highly coordinated disassembly process and form long, beaded protrusions (coined as beaded apoptopodia), which fragment to release ApoBDs. Here, we find that the protein plexin B2 (PlexB2), a transmembrane receptor that regulates axonal guidance in neurons, is enriched in the ApoBDs of THP1 monocytes and is a caspase 3/7 substrate. To determine whether PlexB2 is involved in the disassembly of apoptotic monocytes, we generate PlexB2-deficient THP1 monocytes and demonstrate that lack of PlexB2 impairs the formation of beaded apoptopodia and ApoBDs. Consequently, the loss of PlexB2 in apoptotic THP1 monocytes impairs their uptake by both professional and non-professional phagocytes. Altogether, these data identify PlexB2 as a positive regulator of apoptotic monocyte disassembly and demonstrate the importance of this process in apoptotic cell clearance.

journal_name

Cell Rep

journal_title

Cell reports

authors

Atkin-Smith GK,Miles MA,Tixeira R,Lay FT,Duan M,Hawkins CJ,Phan TK,Paone S,Mathivanan S,Hulett MD,Chen W,Poon IKH

doi

10.1016/j.celrep.2019.10.014

subject

Has Abstract

pub_date

2019-11-12 00:00:00

pages

1821-1831.e3

issue

7

issn

2211-1247

pii

S2211-1247(19)31314-2

journal_volume

29

pub_type

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