Abstract：
:During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune tolerance to invading fetal extravillous trophoblasts (EVTs). CD25HIFOXP3+ Tregs are found at high levels in decidual tissues and have been shown to suppress fetus-specific and nonspecific responses. However, limited data are available on additional decidual Treg types and the mechanisms by which they are induced. This study investigated three distinct decidual CD4+ Treg types in healthy pregnancies with a regulatory phenotype and the ability to suppress T cell responses: CD25HIFOXP3+, PD1HIIL-10+, and TIGIT+FOXP3dim. Moreover, co-culture of HLA-G+ EVTs or decidual macrophages with blood CD4+ T cells directly increased the proportions of CD25HIFOXP3+ Tregs compared to T cells cultured alone. EVTs also increased PD1HI Tregs that could be inhibited by HLA-C and CD3 antibodies, suggesting an antigen-specific induction. The presence of distinct Treg types may allow for the modulation of a variety of inflammatory responses in the placenta.
journal_name
Cell Repjournal_title
Cell reportsauthors
Salvany-Celades M,van der Zwan A,Benner M,Setrajcic-Dragos V,Bougleux Gomes HA,Iyer V,Norwitz ER,Strominger JL,Tilburgs Tdoi
10.1016/j.celrep.2019.04.109subject
Has Abstractpub_date
2019-05-28 00:00:00pages
2537-2547.e5issue
9issn
2211-1247pii
S2211-1247(19)30599-6journal_volume
27pub_type
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