Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites.

abstract：:The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator by linking cellular metabolism to substrate AMP-activated protein kinase (AMPK). We show th...

journal_title：Cell reports

authors： Timilshina M,You Z,Lacher SM,Acharya S,Jiang L,Kang Y,Kim JA,Chang HW,Kim KJ,Park B,Song JH,Ko HJ,Park YY,Ma MJ,Nepal MR,Jeong TC,Chung Y,Waisman A,Chang JH

更新日期：2019-06-04 00:00:00

abstract：:Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene ...

journal_title：Cell reports

authors： Hatakeyama H,Wu SY,Lyons YA,Pradeep S,Wang W,Huang Q,Court KA,Liu T,Nie S,Rodriguez-Aguayo C,Shen F,Huang Y,Hisamatsu T,Mitamura T,Jennings N,Shim J,Dorniak PL,Mangala LS,Petrillo M,Petyuk VA,Schepmoes AA,Shukla

更新日期：2016-11-01 00:00:00

abstract：:Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA) and Joubert-syndrome and related disorders (JSRD). We examined cilia biogenesis and function in cells derived from CEP290-LCA and CEP290-JSRD patients. CEP290 protein was reduced in L...

journal_title：Cell reports

authors： Shimada H,Lu Q,Insinna-Kettenhofen C,Nagashima K,English MA,Semler EM,Mahgerefteh J,Cideciyan AV,Li T,Brooks BP,Gunay-Aygun M,Jacobson SG,Cogliati T,Westlake CJ,Swaroop A

更新日期：2017-07-11 00:00:00

abstract：:Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature fo...

journal_title：Cell reports

authors： Spatazza J,Lee HH,Di Nardo AA,Tibaldi L,Joliot A,Hensch TK,Prochiantz A

更新日期：2013-06-27 00:00:00

abstract：:Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27dull and CD27bright MBCs, whose frequency changes with age. Heavy chain variable region (VH) usage, somatic mutation frequency replacement-to-silent ratio, and CDR3 property chan...

journal_title：Cell reports

authors： Grimsholm O,Piano Mortari E,Davydov AN,Shugay M,Obraztsova AS,Bocci C,Marasco E,Marcellini V,Aranburu A,Farroni C,Silvestris DA,Cristofoletti C,Giorda E,Scarsella M,Cascioli S,Barresi S,Lougaris V,Plebani A,Cancrini C

更新日期：2020-03-03 00:00:00

abstract：:The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central component of mTORC1 and alters the kinetics of excitatory synaptic transmission. We show that ...

journal_title：Cell reports

authors： Kouloulia S,Hallin EI,Simbriger K,Amorim IS,Lach G,Amvrosiadis T,Chalkiadaki K,Kampaite A,Truong VT,Hooshmandi M,Jafarnejad SM,Skehel P,Kursula P,Khoutorsky A,Gkogkas CG

更新日期：2019-12-10 00:00:00

abstract：:Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show that the endonuclease Regnase-1 is critical for the degradation ...

journal_title：Cell reports

authors： Yoshinaga M,Nakatsuka Y,Vandenbon A,Ori D,Uehata T,Tsujimura T,Suzuki Y,Mino T,Takeuchi O

更新日期：2017-05-23 00:00:00

abstract：:Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To generate neurons, V-SVZ NSCs need to activate and enter the ce...

journal_title：Cell reports

authors： Engler A,Rolando C,Giachino C,Saotome I,Erni A,Brien C,Zhang R,Zimber-Strobl U,Radtke F,Artavanis-Tsakonas S,Louvi A,Taylor V

更新日期：2018-01-23 00:00:00

abstract：:Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. Here, we demonstrate that the loss of CD4 Th1 cells specifically leads to progressive CD8 T cell decline and dysfunction during viral p...

journal_title：Cell reports

authors： Snell LM,Osokine I,Yamada DH,De la Fuente JR,Elsaesser HJ,Brooks DG

更新日期：2016-09-20 00:00:00

abstract：:In the eukaryotic cell, spliceosomes assemble onto pre-mRNA cotranscriptionally. Spliceosome assembly takes place in the context of the chromatin environment, suggesting that the state of the chromatin may affect splicing. The molecular details and mechanisms through which chromatin affects splicing, however, are stil...

journal_title：Cell reports

authors： Leung CS,Douglass SM,Morselli M,Obusan MB,Pavlyukov MS,Pellegrini M,Johnson TL

更新日期：2019-06-25 00:00:00

abstract：:Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact th...

journal_title：Cell reports

authors： Oberle SG,Hanna-El-Daher L,Chennupati V,Enouz S,Scherer S,Prlic M,Zehn D

更新日期：2016-10-11 00:00:00

abstract：:Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, and understanding this diversity is key for designing selective or biased drugs for them. Here, we determine two crystal structures of the α2A adrenergic receptor (α2AAR) in complex with a partia...

journal_title：Cell reports

authors： Qu L,Zhou Q,Xu Y,Guo Y,Chen X,Yao D,Han GW,Liu ZJ,Stevens RC,Zhong G,Wu D,Zhao S

更新日期：2019-12-03 00:00:00

abstract：:Impulses generated by a multicellular, bioelectric signaling center termed the sinoatrial node (SAN) stimulate the rhythmic contraction of the heart. The SAN consists of a network of electrochemically oscillating pacemaker cells encased in a heterogeneous connective tissue microenvironment. Although the cellular compo...

journal_title：Cell reports

authors： Bressan M,Henley T,Louie JD,Liu G,Christodoulou D,Bai X,Taylor J,Seidman CE,Seidman JG,Mikawa T

更新日期：2018-05-22 00:00:00

abstract：:Fear extinction is a component of cognitive flexibility that is relevant for important psychiatric diseases, but its molecular mechanism is still largely elusive. We established mice lacking the kinesin-4 motor KIF21B as a model for fear extinction defects. Postsynaptic NMDAR-dependent long-term depression (LTD) is sp...

journal_title：Cell reports

authors： Morikawa M,Tanaka Y,Cho HS,Yoshihara M,Hirokawa N

更新日期：2018-06-26 00:00:00

abstract：:During development, two cell types born from closely related progenitor pools often express identical transcriptional regulators despite their completely distinct characteristics. This phenomenon implies the need for a mechanism that operates to segregate the identities of the two cell types throughout differentiation...

journal_title：Cell reports

authors： Clovis YM,Seo SY,Kwon JS,Rhee JC,Yeo S,Lee JW,Lee S,Lee SK

更新日期：2016-08-09 00:00:00

abstract：:In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. This system was...

journal_title：Cell reports

authors： Monfort A,Di Minin G,Postlmayr A,Freimann R,Arieti F,Thore S,Wutz A

更新日期：2015-07-28 00:00:00

abstract：:The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after T cell activation. Phosp...

journal_title：Cell reports

authors： Gehring T,Erdmann T,Rahm M,Graß C,Flatley A,O'Neill TJ,Woods S,Meininger I,Karayel O,Kutzner K,Grau M,Shinohara H,Lammens K,Feederle R,Hauck SM,Lenz G,Krappmann D

更新日期：2019-10-22 00:00:00

abstract：:Blood flow regulation in pancreatic islets is critical for function but poorly understood. Here, we establish an in vivo imaging platform in a non-human primate where islets transplanted autologously into the anterior chamber of the eye are monitored non-invasively and longitudinally at single-cell resolution. Engraft...

journal_title：Cell reports

authors： Diez JA,Arrojo E Drigo R,Zheng X,Stelmashenko OV,Chua M,Rodriguez-Diaz R,Fukuda M,Köhler M,Leibiger I,Tun SBB,Ali Y,Augustine GJ,Barathi VA,Berggren PO

更新日期：2017-08-08 00:00:00

abstract：:Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR acti...

journal_title：Cell reports

authors： Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA 3rd,Hitosugi T,Bernlohr DA,Sun J,Zeng H

更新日期：2021-01-05 00:00:00

abstract：:A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study the origin of novelties because mammals preserve stages in the...

journal_title：Cell reports

authors： Lynch VJ,Nnamani MC,Kapusta A,Brayer K,Plaza SL,Mazur EC,Emera D,Sheikh SZ,Grützner F,Bauersachs S,Graf A,Young SL,Lieb JD,DeMayo FJ,Feschotte C,Wagner GP

更新日期：2015-02-03 00:00:00

abstract：:The kidney has a tremendous capacity to regenerate following injury, but factors that govern this response are still largely unknown. We isolated cells from mouse kidneys with high proliferative and multi-lineage differentiation capacity. These cells expressed a high level of Sox9. In regenerating kidneys, Sox9 expres...

journal_title：Cell reports

authors： Kang HM,Huang S,Reidy K,Han SH,Chinga F,Susztak K

更新日期：2016-02-02 00:00:00

abstract：:Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precisely how these phenomena are linked, however, remains unclear. Using a cortico-hip...

journal_title：Cell reports

authors： Agasse F,Mendez-David I,Christaller W,Carpentier R,Braz BY,David DJ,Saudou F,Humbert S

更新日期：2020-07-07 00:00:00

abstract：:In Drosophila, it is thought that peptidoglycan recognition proteins (PGRPs) SA and LC structurally discriminate between bacterial peptidoglycans with lysine (Lys) or diaminopimelic (DAP) acid, respectively, thus inducing differential antimicrobial transcription response. Here, we find that accessibility to PG at the ...

journal_title：Cell reports

authors： Vaz F,Kounatidis I,Covas G,Parton RM,Harkiolaki M,Davis I,Filipe SR,Ligoxygakis P

更新日期：2019-05-21 00:00:00

abstract：:Governance of protein phosphorylation by kinases and phosphatases constitutes an essential regulatory network in eukaryotic cells. Network dysregulation leads to severe consequences and is often a key factor in disease pathogenesis. Previous studies revealed multiple roles for protein phosphorylation and pathway struc...

journal_title：Cell reports

authors： Li J,Paulo JA,Nusinow DP,Huttlin EL,Gygi SP

更新日期：2019-11-12 00:00:00

abstract：:Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such changes are detected is not well understood. We identify the HSP70 chaperone as a sensor of changes in...

journal_title：Cell reports

authors： Bailly AP,Perrin A,Serrano-Macia M,Maghames C,Leidecker O,Trauchessec H,Martinez-Chantar ML,Gartner A,Xirodimas DP

更新日期：2019-10-01 00:00:00

abstract：:Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in the main target cells of HIV-1 in vivo. Here, we show that activated CD4+ T ...

journal_title：Cell reports

authors： Vermeire J,Roesch F,Sauter D,Rua R,Hotter D,Van Nuffel A,Vanderstraeten H,Naessens E,Iannucci V,Landi A,Witkowski W,Baeyens A,Kirchhoff F,Verhasselt B

更新日期：2016-10-04 00:00:00

abstract：:The MRE11-RAD50-NBS1 complex plays a central role in response to DNA double-strand breaks. Here, we identify a patient with bone marrow failure and developmental defects caused by biallelic RAD50 mutations. One of the mutations creates a null allele, whereas the other (RAD50E1035Δ) leads to the loss of a single residu...

journal_title：Cell reports

authors： Chansel-Da Cruz M,Hohl M,Ceppi I,Kermasson L,Maggiorella L,Modesti M,de Villartay JP,Ileri T,Cejka P,Petrini JHJ,Revy P

更新日期：2020-12-29 00:00:00

abstract：:Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate pathogen-induced signals to drive or suppress transcriptional programs speci...

journal_title：Cell reports

authors： Piovesan D,Tempany J,Di Pietro A,Baas I,Yiannis C,O'Donnell K,Chen Y,Peperzak V,Belz GT,Mackay CR,Smyth GK,Groom JR,Tarlinton DM,Good-Jacobson KL

更新日期：2017-04-18 00:00:00

abstract：:Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and Cdt1. We find that the three origins in the single chromosome of the...

journal_title：Cell reports

authors： Samson RY,Xu Y,Gadelha C,Stone TA,Faqiri JN,Li D,Qin N,Pu F,Liang YX,She Q,Bell SD

更新日期：2013-02-21 00:00:00

abstract：:53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other proteins, initial recruitment of 53BP1 to sites of DNA damage de...

journal_title：Cell reports

authors： Baldock RA,Day M,Wilkinson OJ,Cloney R,Jeggo PA,Oliver AW,Watts FZ,Pearl LH

更新日期：2015-12-15 00:00:00