Abstract：
:Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature forebrain. Genetic disruption of choroid-expressed Otx2 impacts these distant circuits and in the primary visual cortex reopens binocular plasticity to restore vision in amblyopic mice. The potential to regulate adult cortical plasticity through the choroid plexus underscores the importance of this structure in brain physiology and offers therapeutic approaches to recovery from a broad range of neurodevelopmental disorders.
journal_name
Cell Repjournal_title
Cell reportsauthors
Spatazza J,Lee HH,Di Nardo AA,Tibaldi L,Joliot A,Hensch TK,Prochiantz Adoi
10.1016/j.celrep.2013.05.014subject
Has Abstractpub_date
2013-06-27 00:00:00pages
1815-23issue
6issn
2211-1247pii
S2211-1247(13)00231-3journal_volume
3pub_type
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