The Secreted Protein C1QL1 and Its Receptor BAI3 Control the Synaptic Connectivity of Excitatory Inputs Converging on Cerebellar Purkinje Cells.

abstract：:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor central to axon regrowth with an enigmatic ability to act in different subcellular regions independently of its transcriptional roles. However, its roles in mature CNS neurons remain unclear. Here, we show that along with nuclear tran...

journal_title：Cell reports

authors： Luo X,Ribeiro M,Bray ER,Lee DH,Yungher BJ,Mehta ST,Thakor KA,Diaz F,Lee JK,Moraes CT,Bixby JL,Lemmon VP,Park KK

更新日期：2016-04-12 00:00:00

abstract：:RIP1 is a central mediator of cell death in response to cell stress but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 acts as a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is coexpressed with EGFRWT in glioblastoma multiforme (GBM). EGFRvIII rec...

journal_title：Cell reports

authors： Puliyappadamba VT,Chakraborty S,Chauncey SS,Li L,Hatanpaa KJ,Mickey B,Noorani S,Shu HK,Burma S,Boothman DA,Habib AA

更新日期：2013-08-29 00:00:00

abstract：:Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell biological processes that lead to mineral nucleation remains elusive. Here, we r...

journal_title：Cell reports

authors： Müller KH,Hayward R,Rajan R,Whitehead M,Cobb AM,Ahmad S,Sun M,Goldberga I,Li R,Bashtanova U,Puszkarska AM,Reid DG,Brooks RA,Skepper JN,Bordoloi J,Chow WY,Oschkinat H,Groombridge A,Scherman OA,Harrison JA,Verhulst

更新日期：2019-06-11 00:00:00

abstract：:The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations of EZH2 and their role in cancer pathogenesis. Here, we show that SET and MYND domain containing 2 (S...

journal_title：Cell reports

authors： Zeng Y,Qiu R,Yang Y,Gao T,Zheng Y,Huang W,Gao J,Zhang K,Liu R,Wang S,Hou Y,Yu W,Leng S,Feng D,Liu W,Zhang X,Wang Y

更新日期：2019-11-05 00:00:00

abstract：:The neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocamp...

journal_title：Cell reports

authors： Zhao R,Grunke SD,Keralapurath MM,Yetman MJ,Lam A,Lee TC,Sousounis K,Jiang Y,Swing DA,Tessarollo L,Ji D,Jankowsky JL

更新日期：2016-07-19 00:00:00

abstract：:Nuclear actin has been elusive due to the lack of knowledge about molecular mechanisms. From actin-containing chromatin remodeling complexes, we discovered an arginine mono-methylation mark on an evolutionarily conserved R256 residue of actin (R256me1). Actin R256 mutations in yeast affect nuclear functions and cause ...

journal_title：Cell reports

authors： Kumar A,Zhong Y,Albrecht A,Sang PB,Maples A,Liu Z,Vinayachandran V,Reja R,Lee CF,Kumar A,Chen J,Xiao J,Park B,Shen J,Liu B,Person MD,Trybus KM,Zhang KYJ,Pugh BF,Kamm KE,Milewicz DM,Shen X,Kapoor P

更新日期：2020-09-29 00:00:00

abstract：:The number of essential telomerase components in the active ribonucleoprotein (RNP) has important implications for its mechanism of action yet is by and large unknown. We report that two differentially tagged TLC1 RNAs endogenously expressed in a heterozygous diploid and simultaneously detected via multi-color fluores...

journal_title：Cell reports

authors： Bajon E,Laterreur N,Wellinger RJ

更新日期：2015-07-21 00:00:00

abstract：:Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular mechanisms governing control or progression of intracellular infections. In this work, we explore the in vivo molecular dynamics of Mtb infection by performing dual RNA-seq on Mycobacterium tuberculosis-infected, ontogenetically d...

journal_title：Cell reports

authors： Pisu D,Huang L,Grenier JK,Russell DG

更新日期：2020-01-14 00:00:00

abstract：:Fibrillarin (FBL) is a dual-function nucleolar protein that catalyzes 2'-O methylation of pre-rRNA and methylation of histone H2A at glutamine 104 (H2AQ104me). The mechanisms that regulate FBL activity are unexplored. Here, we show that FBL is acetylated at several lysine residues by the acetyltransferase CBP and deac...

journal_title：Cell reports

authors： Iyer-Bierhoff A,Krogh N,Tessarz P,Ruppert T,Nielsen H,Grummt I

更新日期：2018-12-11 00:00:00

abstract：:In mammalian cells, classical non-homologous end joining (c-NHEJ) is critical for DNA double-strand break repair induced by ionizing radiation and during V(D)J recombination in developing B and T lymphocytes. Recently, PAXX was identified as a c-NHEJ core component. We report here that PAXX-deficient cells exhibit a c...

journal_title：Cell reports

authors： Tadi SK,Tellier-Lebègue C,Nemoz C,Drevet P,Audebert S,Roy S,Meek K,Charbonnier JB,Modesti M

更新日期：2016-10-04 00:00:00

abstract：:The RNA binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system, and disruption of Rbfox1 has been implicated in autism. However, comprehensive identification of functional Rbfox targets has been challenging. Here, we perform HITS-CLIP for all three Rbfox family members in order to globally map...

journal_title：Cell reports

authors： Weyn-Vanhentenryck SM,Mele A,Yan Q,Sun S,Farny N,Zhang Z,Xue C,Herre M,Silver PA,Zhang MQ,Krainer AR,Darnell RB,Zhang C

更新日期：2014-03-27 00:00:00

abstract：:Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene ...

journal_title：Cell reports

authors： Hatakeyama H,Wu SY,Lyons YA,Pradeep S,Wang W,Huang Q,Court KA,Liu T,Nie S,Rodriguez-Aguayo C,Shen F,Huang Y,Hisamatsu T,Mitamura T,Jennings N,Shim J,Dorniak PL,Mangala LS,Petrillo M,Petyuk VA,Schepmoes AA,Shukla

更新日期：2016-11-01 00:00:00

abstract：:Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate a causal link with another liability factor: low expressi...

journal_title：Cell reports

authors： Bocarsly ME,da Silva E Silva D,Kolb V,Luderman KD,Shashikiran S,Rubinstein M,Sibley DR,Dobbs LK,Alvarez VA

更新日期：2019-10-29 00:00:00

abstract：:Understanding how p53 activates certain gene programs and not others is critical. Here, we identify low-density lipoprotein receptor-related protein 1 (LRP1), a transmembrane endocytic receptor, as a p53 target gene. We show that, although LRP1 transcript expression is upregulated in response to both sub-lethal and le...

journal_title：Cell reports

authors： Leslie PL,Franklin DA,Liu Y,Zhang Y

更新日期：2018-08-07 00:00:00

abstract：:Mitophagy plays an important role in mitochondrial quality control. In yeast, phosphorylation of the mitophagy receptor Atg32 by casein kinase 2 (CK2) upon induction of mitophagy is a prerequisite for interaction of Atg32 with Atg11 (an adaptor protein for selective autophagy) and following delivery of mitochondria to...

journal_title：Cell reports

authors： Furukawa K,Fukuda T,Yamashita SI,Saigusa T,Kurihara Y,Yoshida Y,Kirisako H,Nakatogawa H,Kanki T

更新日期：2018-06-19 00:00:00

abstract：:Antimetabolites that affect nucleotide metabolism are frontline chemotherapy agents in several cancers and often successfully target one carbon metabolism. However, the precise mechanisms and resulting determinants of their therapeutic value are unknown. We show that 5-fluorouracil (5-FU), a commonly used antimetaboli...

journal_title：Cell reports

authors： Ser Z,Gao X,Johnson C,Mehrmohamadi M,Liu X,Li S,Locasale JW

更新日期：2016-06-14 00:00:00

abstract：:The growth of B cell receptor (BCR) microclusters upon antigen stimulation drives B cell activation. Here, we show that PI3K-mediated PIP3 production is required for the growth of BCR microclusters. This growth is likely inhibited by PTEN and dependent on its plasma membrane binding and lipid phosphatase activities. M...

journal_title：Cell reports

authors： Wang J,Xu L,Shaheen S,Liu S,Zheng W,Sun X,Li Z,Liu W

更新日期：2017-11-28 00:00:00

abstract：:Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal TRM cells remains undefined. Here, we investigate transcriptional and functional heterogeneity of human TRM cells through study of donor-derived ...

journal_title：Cell reports

authors： FitzPatrick MEB,Provine NM,Garner LC,Powell K,Amini A,Irwin SL,Ferry H,Ambrose T,Friend P,Vrakas G,Reddy S,Soilleux E,Klenerman P,Allan PJ

更新日期：2021-01-19 00:00:00

abstract：:The neurodevelopmental origin of hyperactivity disorder has been suggested to involve the dopaminergic system, but the underlying mechanisms are still unknown. Here, transcription factors Lmx1a and Lmx1b are shown to be essential for midbrain dopaminergic (mDA) neuron excitatory synaptic inputs and dendritic developme...

journal_title：Cell reports

authors： Salesse C,Charest J,Doucet-Beaupré H,Castonguay AM,Labrecque S,De Koninck P,Lévesque M

更新日期：2020-02-18 00:00:00

abstract：:Two hallmarks of cancer cells are their resistance to apoptosis and ability to thrive despite reduced levels of vital serum components. c-jun N-terminal kinase (JNK) activation is crucial for apoptosis triggered by serum starvation (SS), and isocitrate dehydrogenase 1 (IDH1) mutations are tumorigenic, in part, because...

journal_title：Cell reports

authors： Jiang B,Zhang J,Xia J,Zhao W,Wu Y,Shi M,Luo L,Zhou H,Chen A,Ma H,Zhao Q,Suleman M,Lin F,Zhou L,Wang J,Zhang Y,He Y,Li X,Hung LM,Mak TW,Li Q

更新日期：2017-04-11 00:00:00

abstract：:The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can substitute qualitatively for Nanog function in ESCs. Whether this functional substitution extend...

journal_title：Cell reports

authors： Zhang M,Leitch HG,Tang WWC,Festuccia N,Hall-Ponsele E,Nichols J,Surani MA,Smith A,Chambers I

更新日期：2018-01-09 00:00:00

abstract：:Reactive astrogliosis is an essential and ubiquitous response to CNS injury, but in some cases, aberrant activation of astrocytes and their release of inhibitory signaling molecules can impair endogenous neural repair processes. Our lab previously identified a secreted intercellular signaling molecule, called endothel...

journal_title：Cell reports

authors： Hammond TR,McEllin B,Morton PD,Raymond M,Dupree J,Gallo V

更新日期：2015-12-15 00:00:00

abstract：:The molecular basis of higher regenerative capacity of cold-blooded animals comparing to warm-blooded ones is poorly understood. Although this difference in regenerative capacities is commonly thought to be a result of restructuring of the same regulatory gene network, we hypothesized that it may be due to loss of som...

journal_title：Cell reports

authors： Korotkova DD,Lyubetsky VA,Ivanova AS,Rubanov LI,Seliverstov AV,Zverkov OA,Martynova NY,Nesterenko AM,Tereshina MB,Peshkin L,Zaraisky AG

更新日期：2019-10-22 00:00:00

abstract：:The Piwi-piRNA pathway is well known for its germline function, yet its somatic role remains elusive. We show here that Piwi is required autonomously not only for germline stem cell (GSC) but also for somatic cyst stem cell (CySC) maintenance in the Drosophila testis. Reducing Piwi activity in the testis caused defect...

journal_title：Cell reports

authors： Gonzalez J,Qi H,Liu N,Lin H

更新日期：2015-07-07 00:00:00

abstract：:The conserved NAD+-dependent deacylase SIRT1 plays pivotal, sometimes contrasting, roles in diverse physiological and pathophysiological conditions. In this study, we uncover a tissue-restricted isoform of SIRT1 (SIRT1-ΔE2) that lacks exon 2 (E2). Candidate-based screening of SIRT1 substrates demonstrated that the dom...

journal_title：Cell reports

authors： Deota S,Chattopadhyay T,Ramachandran D,Armstrong E,Camacho B,Maniyadath B,Fulzele A,Gonzalez-de-Peredo A,Denu JM,Kolthur-Seetharam U

更新日期：2017-03-28 00:00:00

abstract：:The Hsp90 chaperone is essential in eukaryotes and activates a large array of client proteins. In contrast, its role is still elusive in bacteria, and only a few Hsp90 bacterial clients are known. Here, we found that Hsp90 is essential in the model bacterium Shewanella oneidensis under heat stress. A genetic screen fo...

journal_title：Cell reports

authors： Honoré FA,Méjean V,Genest O

更新日期：2017-04-25 00:00:00

abstract：:Effector, but not naïve, T cells are activated by toll-like receptor-2 (TLR2) stimulation, leading to cytokine production and proliferation. We found that the differential response is attributable to the lack of expression of the adaptor protein TIRAP in naive T cells. TIRAP expression is induced upon T-cell receptor ...

journal_title：Cell reports

authors： Imanishi T,Unno M,Kobayashi W,Yoneda N,Akira S,Saito T

更新日期：2020-07-21 00:00:00

abstract：:The transcriptional coactivators PGC-1α and PGC-1β are widely thought to be required for mitochondrial biogenesis and fiber typing in skeletal muscle. Here, we show that mice lacking both PGC-1s in myocytes do indeed have profoundly deficient mitochondrial respiration but, surprisingly, have preserved mitochondrial co...

journal_title：Cell reports

authors： Rowe GC,Patten IS,Zsengeller ZK,El-Khoury R,Okutsu M,Bampoh S,Koulisis N,Farrell C,Hirshman MF,Yan Z,Goodyear LJ,Rustin P,Arany Z

更新日期：2013-05-30 00:00:00

abstract：:Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo. Analysis of resting microglia identified 29 genes that distinguish mic...

journal_title：Cell reports

authors： Chiu IM,Morimoto ET,Goodarzi H,Liao JT,O'Keeffe S,Phatnani HP,Muratet M,Carroll MC,Levy S,Tavazoie S,Myers RM,Maniatis T

更新日期：2013-07-25 00:00:00

abstract：:The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of these interactions involve recruitment of the cohesin complex to chromatin via CTCF. We find that CTCF also interacts with the centromeric protein CENP-E both in v...

journal_title：Cell reports

authors： Xiao T,Wongtrakoongate P,Trainor C,Felsenfeld G

更新日期：2015-09-08 00:00:00