miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells.

abstract：:During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune tolerance to invading fetal extravillous trophoblasts (EVTs). CD25HIFOXP3+ Tregs are found at high levels in decidual tissues and have been shown to suppress fetus-specific and nonspecific responses. However, limited data are av...

journal_title：Cell reports

authors： Salvany-Celades M,van der Zwan A,Benner M,Setrajcic-Dragos V,Bougleux Gomes HA,Iyer V,Norwitz ER,Strominger JL,Tilburgs T

更新日期：2019-05-28 00:00:00

abstract：:Activation of postsynaptic metabotropic glutamate receptors (mGluRs) modulates neuronal excitability and synaptic plasticity, while deregulation of mGluR signaling has been implicated in neurodevelopmental disorders. Overstimulation of mGluRs is restricted by the rapid endocytosis of receptors after activation. Howeve...

journal_title：Cell reports

authors： Scheefhals N,Catsburg LAE,Westerveld ML,Blanpied TA,Hoogenraad CC,MacGillavry HD

更新日期：2019-10-08 00:00:00

abstract：:Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of infection remains incomplete. Here, we ...

journal_title：Cell reports

authors： Glennon EKK,Austin LS,Arang N,Kain HS,Mast FD,Vijayan K,Aitchison JD,Kappe SHI,Kaushansky A

更新日期：2019-03-19 00:00:00

abstract：:HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a "block-and-lock" functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA). HIV-1 transcriptional inhibitors could block ongoing viremia during antiretrov...

journal_title：Cell reports

authors： Kessing CF,Nixon CC,Li C,Tsai P,Takata H,Mousseau G,Ho PT,Honeycutt JB,Fallahi M,Trautmann L,Garcia JV,Valente ST

更新日期：2017-10-17 00:00:00

abstract：:Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is central to endothelial cell angiogenic responses, and it is activated by ...

journal_title：Cell reports

authors： Rozen EJ,Roewenstrunk J,Barallobre MJ,Di Vona C,Jung C,Figueiredo AF,Luna J,Fillat C,Arbonés ML,Graupera M,Valverde MA,de la Luna S

更新日期：2018-05-08 00:00:00

abstract：:Antimetabolites that affect nucleotide metabolism are frontline chemotherapy agents in several cancers and often successfully target one carbon metabolism. However, the precise mechanisms and resulting determinants of their therapeutic value are unknown. We show that 5-fluorouracil (5-FU), a commonly used antimetaboli...

journal_title：Cell reports

authors： Ser Z,Gao X,Johnson C,Mehrmohamadi M,Liu X,Li S,Locasale JW

更新日期：2016-06-14 00:00:00

abstract：:Palmitoylation is a reversible post-translational lipid modification that facilitates vesicular transport and subcellular localization of modified proteins. This process is catalyzed by ZDHHC enzymes that are implicated in several neurological and neurodevelopmental disorders. Loss-of-function mutations in ZDHHC9 have...

journal_title：Cell reports

authors： Shimell JJ,Shah BS,Cain SM,Thouta S,Kuhlmann N,Tatarnikov I,Jovellar DB,Brigidi GS,Kass J,Milnerwood AJ,Snutch TP,Bamji SX

更新日期：2019-11-19 00:00:00

abstract：:Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types play a prominent role in drug addiction. To investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing (scRNA-seq) of the nucleus ac...

journal_title：Cell reports

authors： Avey D,Sankararaman S,Yim AKY,Barve R,Milbrandt J,Mitra RD

更新日期：2018-09-25 00:00:00

abstract：:The innate immune system senses cytosolic dsDNA and bacterial cyclic dinucleotides and initiates signaling via the adaptor STING to induce type 1 interferon (IFN) response. We demonstrate here that BTK-deficient cells have impaired IFN-β production and TBK1/IRF3 activation when stimulated with agonists or infected wit...

journal_title：Cell reports

authors： Lee KG,Kim SS,Kui L,Voon DC,Mauduit M,Bist P,Bi X,Pereira NA,Liu C,Sukumaran B,Rénia L,Ito Y,Lam KP

更新日期：2015-02-24 00:00:00

abstract：:During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) accumulation at synapses. Here, we report a critical...

journal_title：Cell reports

authors： Louros SR,Hooks BM,Litvina L,Carvalho AL,Chen C

更新日期：2014-06-12 00:00:00

abstract：:Major depressive disorder is associated with weight loss and decreased appetite; however, the signaling that connects these conditions is unclear. Here, we show that MC4R signaling in the dorsal raphe nucleus (DRN) affects feeding, anxiety, and depression. DRN infusion of α-MSH decreases DRN neuronal activation and fe...

journal_title：Cell reports

authors： Bruschetta G,Jin S,Liu ZW,Kim JD,Diano S

更新日期：2020-10-13 00:00:00

abstract：:MicroRNAs (miRNAs) are typically generated as ~22-nucleotide double-stranded RNAs via the processing of precursor hairpins by the ribonuclease III enzyme Dicer, after which they are loaded into Argonaute (Ago) proteins to form an RNA-induced silencing complex (RISC). However, the biogenesis of miR-451, an erythropoiet...

journal_title：Cell reports

authors： Yoda M,Cifuentes D,Izumi N,Sakaguchi Y,Suzuki T,Giraldez AJ,Tomari Y

更新日期：2013-11-14 00:00:00

abstract：:APOBEC family cytidine deaminases have recently been implicated as powerful mutators of cancer genomes. How APOBECs, which are ssDNA-specific enzymes, gain access to chromosomal DNA is unclear. To ascertain the chromosomal ssDNA substrates of the APOBECs, we expressed APOBEC3A and APOBEC3B, the two most probable APOBE...

journal_title：Cell reports

authors： Hoopes JI,Cortez LM,Mertz TM,Malc EP,Mieczkowski PA,Roberts SA

更新日期：2016-02-16 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, a...

journal_title：Cell reports

authors： Rupaimoole R,Lee J,Haemmerle M,Ling H,Previs RA,Pradeep S,Wu SY,Ivan C,Ferracin M,Dennison JB,Millward NMZ,Nagaraja AS,Gharpure KM,McGuire M,Sam N,Armaiz-Pena GN,Sadaoui NC,Rodriguez-Aguayo C,Calin GA,Drapkin RI,K

更新日期：2015-12-22 00:00:00

abstract：:The twin-ATPase ABCE1 has a vital function in mRNA translation by recycling terminated or stalled ribosomes. As for other functionally distinct ATP-binding cassette (ABC) proteins, the mechanochemical coupling of ATP hydrolysis to conformational changes remains elusive. Here, we use an integrated biophysical approach ...

journal_title：Cell reports

authors： Gouridis G,Hetzert B,Kiosze-Becker K,de Boer M,Heinemann H,Nürenberg-Goloub E,Cordes T,Tampé R

更新日期：2019-07-16 00:00:00

abstract：:The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-translational modifications also influence PP5 phosphatase activity. Here, we show a...

journal_title：Cell reports

authors： Dushukyan N,Dunn DM,Sager RA,Woodford MR,Loiselle DR,Daneshvar M,Baker-Williams AJ,Chisholm JD,Truman AW,Vaughan CK,Haystead TA,Bratslavsky G,Bourboulia D,Mollapour M

更新日期：2017-11-14 00:00:00

abstract：:Infections can result in a temporarily restricted unresponsiveness of the innate immune response, thereby limiting pathogen control. Mechanisms of such unresponsiveness are well studied in lipopolysaccharide tolerance; however, whether mechanisms of tolerance limit innate immunity during virus infection remains unknow...

journal_title：Cell reports

authors： Adomati T,Cham LB,Hamdan TA,Bhat H,Duhan V,Li F,Ali M,Lang E,Huang A,Naser E,Khairnar V,Friedrich SK,Lang J,Friebus-Kardash J,Bergerhausen M,Schiller M,Machlah YM,Lang F,Häussinger D,Ferencik S,Hardt C,Lang PA,

更新日期：2020-03-17 00:00:00

abstract：:Molecular processes involving lncRNAs regulate cell function. By applying transcriptomics, we identify lncRNAs whose expression is regulated by transforming growth factor β (TGF-β). Upon silencing individual lncRNAs, we identify several that regulate TGF-β signaling. Among these lncRNAs, TGFB2-antisense RNA1 (TGFB2-AS...

journal_title：Cell reports

authors： Papoutsoglou P,Tsubakihara Y,Caja L,Morén A,Pallis P,Ameur A,Heldin CH,Moustakas A

更新日期：2019-09-17 00:00:00

abstract：:PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...

journal_title：Cell reports

authors： Matsumoto N,Sato K,Nishimasu H,Namba Y,Miyakubi K,Dohmae N,Ishitani R,Siomi H,Siomi MC,Nureki O

更新日期：2015-04-21 00:00:00

abstract：:PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR). We show a robust physical interaction between PARP1 and the replication fork protein TI...

journal_title：Cell reports

authors： Young LM,Marzio A,Perez-Duran P,Reid DA,Meredith DN,Roberti D,Star A,Rothenberg E,Ueberheide B,Pagano M

更新日期：2015-10-20 00:00:00

abstract：:CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have aimed to genetically reprogram innate immunity, the utility of current approaches is restricted by poor knockout efficiencies or limited specificity for mature...

journal_title：Cell reports

authors： Riggan L,Hildreth AD,Rolot M,Wong YY,Satyadi W,Sun R,Huerta C,O'Sullivan TE

更新日期：2020-05-19 00:00:00

abstract：:The Hsp90 chaperone is essential in eukaryotes and activates a large array of client proteins. In contrast, its role is still elusive in bacteria, and only a few Hsp90 bacterial clients are known. Here, we found that Hsp90 is essential in the model bacterium Shewanella oneidensis under heat stress. A genetic screen fo...

journal_title：Cell reports

authors： Honoré FA,Méjean V,Genest O

更新日期：2017-04-25 00:00:00

abstract：:Normal mammalian brain aging is characterized by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous investigations have quantified this morphologically, the molecular pathways orchestrating preferential ...

journal_title：Cell reports

authors： Graham LC,Naldrett MJ,Kohama SG,Smith C,Lamont DJ,McColl BW,Gillingwater TH,Skehel P,Urbanski HF,Wishart TM

更新日期：2019-04-23 00:00:00

abstract：:Parkinson's disease (PD) has been attributed to a combination of genetic and nongenetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We applied induced pluripotent stem cell (iPSC) technology for PD disease modeling ...

journal_title：Cell reports

authors： Woodard CM,Campos BA,Kuo SH,Nirenberg MJ,Nestor MW,Zimmer M,Mosharov EV,Sulzer D,Zhou H,Paull D,Clark L,Schadt EE,Sardi SP,Rubin L,Eggan K,Brock M,Lipnick S,Rao M,Chang S,Li A,Noggle SA

更新日期：2014-11-20 00:00:00

abstract：:ATP citrate lyase (ACL) plays a key role in regulating mitochondrial function, as well as glucose and lipid metabolism in skeletal muscle. We report here that ACL silencing impairs myoblast and satellite cell (SC) differentiation, and it is accompanied by a decrease in fast myosin heavy chain isoforms and MYOD. Conver...

journal_title：Cell reports

authors： Das S,Morvan F,Morozzi G,Jourde B,Minetti GC,Kahle P,Rivet H,Brebbia P,Toussaint G,Glass DJ,Fornaro M

更新日期：2017-12-12 00:00:00

abstract：:Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such changes are detected is not well understood. We identify the HSP70 chaperone as a sensor of changes in...

journal_title：Cell reports

authors： Bailly AP,Perrin A,Serrano-Macia M,Maghames C,Leidecker O,Trauchessec H,Martinez-Chantar ML,Gartner A,Xirodimas DP

更新日期：2019-10-01 00:00:00

abstract：:Building an integrated view of cellular responses to environmental cues remains a fundamental challenge due to the complexity of intracellular networks in mammalian cells. Here, we introduce an integrative biochemical and genetic framework to dissect signal transduction events using multiple data types and, in particu...

journal_title：Cell reports

authors： Mertins P,Przybylski D,Yosef N,Qiao J,Clauser K,Raychowdhury R,Eisenhaure TM,Maritzen T,Haucke V,Satoh T,Akira S,Carr SA,Regev A,Hacohen N,Chevrier N

更新日期：2017-06-27 00:00:00

abstract：:Prior studies have shown that aversive olfactory memory is acquired by dopamine acting on a specific receptor, dDA1, expressed by mushroom body neurons. Active forgetting is mediated by dopamine acting on another receptor, Damb, expressed by the same neurons. Surprisingly, prior studies have shown that both receptors ...

journal_title：Cell reports

authors： Himmelreich S,Masuho I,Berry JA,MacMullen C,Skamangas NK,Martemyanov KA,Davis RL

更新日期：2017-11-21 00:00:00

abstract：:Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program of multisite phosphorylation that regulates the conversion of Gli proteins into transcriptional activators. In the absence of Hh ligands, Gli activity is restrained by the direct phospho...

journal_title：Cell reports

authors： Niewiadomski P,Kong JH,Ahrends R,Ma Y,Humke EW,Khan S,Teruel MN,Novitch BG,Rohatgi R

更新日期：2014-01-16 00:00:00

abstract：:CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which are enriched for 3' UTRs in synaptic protein-coding genes. ...

journal_title：Cell reports

authors： Rieger MA,King DM,Crosby H,Liu Y,Cohen BA,Dougherty JD

更新日期：2020-12-22 00:00:00