Abstract：
:Normal mammalian brain aging is characterized by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous investigations have quantified this morphologically, the molecular pathways orchestrating preferential synaptic vulnerability remain to be elucidated. Using quantitative proteomics and healthy rhesus macaque and human patient brain regional tissues, we have comprehensively profiled the temporal expression of the synaptic proteome throughout the adult lifespan in differentially vulnerable brain regions. Comparative profiling of hippocampal (age vulnerable) and occipital cortex (age resistant) synapses revealed discrete and dynamic alterations in the synaptic proteome, which appear unequivocally conserved between species. The generation of these unique and important datasets will aid in delineating the molecular mechanisms underpinning primate brain aging, in addition to deciphering the regulatory biochemical cascades governing neurodegenerative disease pathogenesis.
journal_name
Cell Repjournal_title
Cell reportsauthors
Graham LC,Naldrett MJ,Kohama SG,Smith C,Lamont DJ,McColl BW,Gillingwater TH,Skehel P,Urbanski HF,Wishart TMdoi
10.1016/j.celrep.2019.03.096subject
Has Abstractpub_date
2019-04-23 00:00:00pages
1018-1026.e4issue
4issn
2211-1247pii
S2211-1247(19)30435-8journal_volume
27pub_type
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