当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling.

Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling.

Abstract：

:Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the lipidome of white adipose tissue (WAT) and brown adipose tissue (BAT) are unknown. Here, we utilize MS/MSALL shotgun lipidomics to determine the molecular signatures of exercise-induced adaptations to subcutaneous WAT (scWAT) and BAT. Three weeks of exercise training decrease specific molecular species of phosphatidic acid (PA), phosphatidylcholines (PC), phosphatidylethanolamines (PE), and phosphatidylserines (PS) in scWAT and increase specific molecular species of PC and PE in BAT. Exercise also decreases most triacylglycerols (TAGs) in scWAT and BAT. In summary, exercise-induced changes to the scWAT and BAT lipidome are highly specific to certain molecular lipid species, indicating that changes in tissue lipid content reflect selective remodeling in scWAT and BAT of both phospholipids and glycerol lipids in response to exercise training, thus providing a comprehensive resource for future studies of lipid metabolism pathways.

journal_name

Cell Rep

journal_title

Cell reports

authors

May FJ,Baer LA,Lehnig AC,So K,Chen EY,Gao F,Narain NR,Gushchina L,Rose A,Doseff AI,Kiebish MA,Goodyear LJ,Stanford KI

doi

10.1016/j.celrep.2017.01.038

subject

Has Abstract

pub_date

2017-02-07 00:00:00

pages

1558-1572

issue

6

issn

2211-1247

pii

S2211-1247(17)30092-X

journal_volume

18

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.

    abstract：:HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a "block-and-lock" functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA). HIV-1 transcriptional inhibitors could block ongoing viremia during antiretrov...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.09.080

    authors： Kessing CF,Nixon CC,Li C,Tsai P,Takata H,Mousseau G,Ho PT,Honeycutt JB,Fallahi M,Trautmann L,Garcia JV,Valente ST

    更新日期：2017-10-17 00:00:00

  • Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis.

    abstract：:The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the onset of acute inflammation, CD38 levels are increased, leading to the pr...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.12.090

    authors： Joe Y,Chen Y,Park J,Kim HJ,Rah SY,Ryu J,Cho GJ,Choi HS,Ryter SW,Park JW,Kim UH,Chung HT

    更新日期：2020-01-28 00:00:00

  • The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.

    abstract：:To understand how the Bcl6 transcriptional repressor functions in the immune system, we disrupted its RD2 repression domain in mice. Bcl6RD2(MUT) mice exhibit a complete loss of germinal center (GC) formation but retain normal extrafollicular responses. Bcl6RD2(MUT) antigen-engaged B cells migrate to the interfollicul...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.07.059

    authors： Huang C,Gonzalez DG,Cote CM,Jiang Y,Hatzi K,Teater M,Dai K,Hla T,Haberman AM,Melnick A

    更新日期：2014-09-11 00:00:00

  • A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present.

    abstract：:Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.10.024

    authors： Sheng J,Chen Q,Soncin I,Ng SL,Karjalainen K,Ruedl C

    更新日期：2017-10-31 00:00:00

  • Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice.

    abstract：:5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be elucidated. Here, we show that chronic restraint stress (CRS) induced depression-l...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.11.061

    authors： Cheng Y,Sun M,Chen L,Li Y,Lin L,Yao B,Li Z,Wang Z,Chen J,Miao Z,Xin N,Huang L,Allen EG,Wu H,Xu X,Jin P

    更新日期：2018-12-11 00:00:00

  • A LIN28B Tumor-Specific Transcript in Cancer.

    abstract：:The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor p...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.002

    authors： Guo W,Hu Z,Bao Y,Li Y,Li S,Zheng Q,Lyu D,Chen D,Yu T,Li Y,Zhu X,Ding J,Zhao Y,He X,Huang S

    更新日期：2018-02-20 00:00:00

  • The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes.

    abstract：:Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators that ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.037

    authors： Xing F,Luan Y,Cai J,Wu S,Mai J,Gu J,Zhang H,Li K,Lin Y,Xiao X,Liang J,Li Y,Chen W,Tan Y,Sheng L,Lu B,Lu W,Gao M,Qiu P,Su X,Yin W,Hu J,Chen Z,Sai K,Wang J,Chen F,Chen Y,Zhu S,Liu D,Cheng S,Xie Z

    更新日期：2017-01-10 00:00:00

  • Accessibility to Peptidoglycan Is Important for the Recognition of Gram-Positive Bacteria in Drosophila.

    abstract：:In Drosophila, it is thought that peptidoglycan recognition proteins (PGRPs) SA and LC structurally discriminate between bacterial peptidoglycans with lysine (Lys) or diaminopimelic (DAP) acid, respectively, thus inducing differential antimicrobial transcription response. Here, we find that accessibility to PG at the ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.04.103

    authors： Vaz F,Kounatidis I,Covas G,Parton RM,Harkiolaki M,Davis I,Filipe SR,Ligoxygakis P

    更新日期：2019-05-21 00:00:00

  • Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone.

    abstract：:Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To generate neurons, V-SVZ NSCs need to activate and enter the ce...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.12.094

    authors： Engler A,Rolando C,Giachino C,Saotome I,Erni A,Brien C,Zhang R,Zimber-Strobl U,Radtke F,Artavanis-Tsakonas S,Louvi A,Taylor V

    更新日期：2018-01-23 00:00:00

  • Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction.

    abstract：:Recent rapid progress in the field of mechanobiology has been driven by novel emerging tools and methodologies and growing interest from different scientific disciplines. Specific progress has been made toward understanding how cell mechanics is linked to intracellular signaling and the regulation of gene expression i...

    journal_title：Cell reports

    pub_type： 杂志文章,评审

    doi：10.1016/j.celrep.2019.08.075

    authors： Cox CD,Bavi N,Martinac B

    更新日期：2019-10-01 00:00:00

  • 3' UTR-dependent, miR-92-mediated restriction of Tis21 expression maintains asymmetric neural stem cell division to ensure proper neocortex size.

    abstract：:Mammalian neocortex size primarily reflects the number and mode of divisions of neural stem and progenitor cells. Cortical stem cells (apical progenitors) switching from symmetric divisions, which expand their population, to asymmetric divisions, which generate downstream neuronal progenitors (basal progenitors), star...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.03.033

    authors： Fei JF,Haffner C,Huttner WB

    更新日期：2014-04-24 00:00:00

  • Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors.

    abstract：:Medium spiny neurons (MSNs) of mice show opposing activities upon the initiation of a food-seeking lever press task. Ventromedial striatal (VMS)-MSNs are inhibited but ventrolateral striatal (VLS)-MSNs are activated; these activities mediate action selection and action initiation, respectively. To understand what inpu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107829

    authors： Yoshida K,Tsutsui-Kimura I,Kono A,Yamanaka A,Kobayashi K,Watanabe M,Mimura M,Tanaka KF

    更新日期：2020-06-30 00:00:00

  • Macrohistone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming to pluripotency.

    abstract：:Transcription-factor-induced reprogramming of somatic cells to pluripotency is a very inefficient process, probably due to the existence of important epigenetic barriers that are imposed during differentiation and that contribute to preserving cell identity. In an effort to decipher the molecular nature of these barri...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.02.029

    authors： Barrero MJ,Sese B,Kuebler B,Bilic J,Boue S,Martí M,Izpisua Belmonte JC

    更新日期：2013-04-25 00:00:00

  • αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish.

    abstract：:The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to be accelerated aging due to hyperphosphatemia and soft tissue calcification. In contrast, the overexpression of αKlotho increases lifespan. Given the severe mouse phenotype, we generated zebrafish mutants for αklotho as well as i...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.08.013

    authors： Singh AP,Sosa MX,Fang J,Shanmukhappa SK,Hubaud A,Fawcett CH,Molind GJ,Tsai T,Capodieci P,Wetzel K,Sanchez E,Wang G,Coble M,Tang W,Cadena SM,Fishman MC,Glass DJ

    更新日期：2019-09-10 00:00:00

  • Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.

    abstract：:Spinal cord longitudinal axons comprise some of the longest axons in our body. However, mechanisms that drive this extra long-distance axonal growth are largely unclear. We found that ascending axons of rapidly adapting (RA) mechanoreceptors closely abut a previously undescribed population of roof plate-derived radial...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.05.025

    authors： Kridsada K,Niu J,Haldipur P,Wang Z,Ding L,Li JJ,Lindgren AG,Herrera E,Thomas GM,Chizhikov VV,Millen KJ,Luo W

    更新日期：2018-06-05 00:00:00

  • Insights into Centromere DNA Bending Revealed by the Cryo-EM Structure of the Core Centromere Binding Factor 3 with Ndc10.

    abstract：:The centromere binding factor 3 (CBF3) complex binds the third centromere DNA element in organisms with point centromeres, such as S. cerevisiae. It is an essential complex for assembly of the kinetochore in these organisms, as it facilitates genetic centromere specification and allows association of all other kinetoc...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.06.068

    authors： Zhang W,Lukoyanova N,Miah S,Lucas J,Vaughan CK

    更新日期：2018-07-17 00:00:00

  • Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.

    abstract：:The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;Runx3 double-knockout (DKO) mice exhibited lethal phenotypes due to bo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.046

    authors： Wang CQ,Krishnan V,Tay LS,Chin DW,Koh CP,Chooi JY,Nah GS,Du L,Jacob B,Yamashita N,Lai SK,Tan TZ,Mori S,Tanuichi I,Tergaonkar V,Ito Y,Osato M

    更新日期：2014-08-07 00:00:00

  • Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity.

    abstract：:Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor immunity are unclear. Here, clinical candidate STING agonist ADU-S100 (S100) is used in an IT dosing regimen optimized for adaptive immunity to uncover requirem...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.11.047

    authors： Sivick KE,Desbien AL,Glickman LH,Reiner GL,Corrales L,Surh NH,Hudson TE,Vu UT,Francica BJ,Banda T,Katibah GE,Kanne DB,Leong JJ,Metchette K,Bruml JR,Ndubaku CO,McKenna JM,Feng Y,Zheng L,Bender SL,Cho CY,Leong ML

    更新日期：2018-12-11 00:00:00

  • A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans.

    abstract：:The MRE11-RAD50-NBS1 complex plays a central role in response to DNA double-strand breaks. Here, we identify a patient with bone marrow failure and developmental defects caused by biallelic RAD50 mutations. One of the mutations creates a null allele, whereas the other (RAD50E1035Δ) leads to the loss of a single residu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108559

    authors： Chansel-Da Cruz M,Hohl M,Ceppi I,Kermasson L,Maggiorella L,Modesti M,de Villartay JP,Ileri T,Cejka P,Petrini JHJ,Revy P

    更新日期：2020-12-29 00:00:00

  • Tumor suppression by p53: is apoptosis important or not?

    abstract：:The mechanisms by which p53 suppresses tumor growth remain ill defined. In this issue of Cell Reports, Timofeev et al. (2013) and Valente et al. (2013) reveal context-dependent contributions of p53-dependent apoptosis to its tumor-suppressive function. ...

    journal_title：Cell reports

    pub_type： 评论,杂志文章

    doi：10.1016/j.celrep.2013.05.011

    authors： Mellert H,Espinosa JM

    更新日期：2013-05-30 00:00:00

  • Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1.

    abstract：:Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.10.063

    authors： Nersesyan Y,Demirkhanyan L,Cabezas-Bratesco D,Oakes V,Kusuda R,Dawson T,Sun X,Cao C,Cohen AM,Chelluboina B,Veeravalli KK,Zimmermann K,Domene C,Brauchi S,Zakharian E

    更新日期：2017-11-07 00:00:00

  • Transcriptional Regulation of Lipophorin Receptors Supports Neuronal Adaptation to Chronic Elevations of Activity.

    abstract：:Activity-dependent modifications strongly influence neural development. However, molecular programs underlying their context and circuit-specific effects are not well understood. To study global transcriptional changes associated with chronic elevation of synaptic activity, we performed cell-type-specific transcriptom...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.016

    authors： Yin J,Gibbs M,Long C,Rosenthal J,Kim HS,Kim A,Sheng C,Ding P,Javed U,Yuan Q

    更新日期：2018-10-30 00:00:00

  • Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner.

    abstract：:During an infection the antigen-nonspecific memory CD8 T cell compartment is not simply an inert pool of cells, but becomes activated and cytotoxic. It is unknown how these cells contribute to the clearance of an infection. We measured the strength of T cell receptor (TCR) signals that bystander-activated, cytotoxic C...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.02.020

    authors： Chu T,Tyznik AJ,Roepke S,Berkley AM,Woodward-Davis A,Pattacini L,Bevan MJ,Zehn D,Prlic M

    更新日期：2013-03-28 00:00:00

  • Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.

    abstract：:In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during "open" mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are "closed," during which the NE is maintained. Intriguingly, during the second meiotic division (MII), the NE is also main...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.073

    authors： Flor-Parra I,Iglesias-Romero AB,Salas-Pino S,Lucena R,Jimenez J,Daga RR

    更新日期：2018-04-24 00:00:00

  • ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis.

    abstract：:ASXL2 is an ETP family protein that interacts with PPARγ. We find that ASXL2-/- mice are insulin resistant, lipodystrophic, and fail to respond to a high-fat diet. Consistent with genetic variation at the ASXL2 locus and human bone mineral density, ASXL2-/- mice are also severely osteopetrotic because of failed osteoc...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.05.019

    authors： Izawa T,Rohatgi N,Fukunaga T,Wang QT,Silva MJ,Gardner MJ,McDaniel ML,Abumrad NA,Semenkovich CF,Teitelbaum SL,Zou W

    更新日期：2015-06-16 00:00:00

  • A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring.

    abstract：:Maternal diabetes is known to adversely influence brain development in offspring. Here, we provide evidence that this involves the circulating metabolite methylglyoxal, which is increased in diabetes, and its detoxifying enzyme, glyoxalase 1 (Glo1), which when mutated is associated with neurodevelopmental disorders. S...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.09.067

    authors： Yang G,Cancino GI,Zahr SK,Guskjolen A,Voronova A,Gallagher D,Frankland PW,Kaplan DR,Miller FD

    更新日期：2016-10-18 00:00:00

  • Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death.

    abstract：:Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe an...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.050

    authors： Galimov ER,Pryor RE,Poole SE,Benedetto A,Pincus Z,Gems D

    更新日期：2018-03-06 00:00:00

  • miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.

    abstract：:MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells follow...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.060

    authors： Chen Z,Stelekati E,Kurachi M,Yu S,Cai Z,Manne S,Khan O,Yang X,Wherry EJ

    更新日期：2017-09-12 00:00:00

  • Analysis of the S. pombe Meiotic Proteome Reveals a Switch from Anabolic to Catabolic Processes and Extensive Post-transcriptional Regulation.

    abstract：:Meiotic progression in S. pombe is regulated by stage-specific gene expression and translation, changes in RNA stability, expression of anti-sense transcripts, and targeted proteolysis of regulatory proteins. We have used SILAC labeling to examine the relative levels of proteins in diploid S. pombe cells during meiosi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.12.075

    authors： Krapp A,Hamelin R,Armand F,Chiappe D,Krapp L,Cano E,Moniatte M,Simanis V

    更新日期：2019-01-22 00:00:00

  • Microtubule Destabilizer KIF2A Undergoes Distinct Site-Specific Phosphorylation Cascades that Differentially Affect Neuronal Morphogenesis.

    abstract：:Neurons exhibit dynamic structural changes in response to extracellular stimuli. Microtubules (MTs) provide rapid and dramatic cytoskeletal changes within the structural framework. However, the molecular mechanisms and signaling networks underlying MT dynamics remain unknown. Here, we have applied a comprehensive and ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.08.018

    authors： Ogawa T,Hirokawa N

    更新日期：2015-09-22 00:00:00