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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity.

Abstract：

:Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor immunity are unclear. Here, clinical candidate STING agonist ADU-S100 (S100) is used in an IT dosing regimen optimized for adaptive immunity to uncover requirements for a T cell-driven response compatible with checkpoint inhibitors (CPIs). In contrast to high-dose tumor ablative regimens that result in systemic S100 distribution, low-dose immunogenic regimens induce local activation of tumor-specific CD8+ effector T cells that are responsible for durable anti-tumor immunity and can be enhanced with CPIs. Both hematopoietic cell STING expression and signaling through IFNAR are required for tumor-specific T cell activation, and in the context of optimized T cell responses, TNFα is dispensable for tumor control. In a poorly immunogenic model, S100 combined with CPIs generates a survival benefit and durable protection. These results provide fundamental mechanistic insights into STING-induced anti-tumor immunity.

journal_name

Cell Rep

journal_title

Cell reports

authors

Sivick KE,Desbien AL,Glickman LH,Reiner GL,Corrales L,Surh NH,Hudson TE,Vu UT,Francica BJ,Banda T,Katibah GE,Kanne DB,Leong JJ,Metchette K,Bruml JR,Ndubaku CO,McKenna JM,Feng Y,Zheng L,Bender SL,Cho CY,Leong ML

doi

10.1016/j.celrep.2018.11.047

subject

Has Abstract

pub_date

2018-12-11 00:00:00

pages

3074-3085.e5

issue

11

issn

2211-1247

pii

S2211-1247(18)31810-2

journal_volume

25

pub_type

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