Abstract：
:The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor prognosis in HCC patients. LIN28B-TST initiates from a de novo alternative transcription initiation site that harbors a strong promoter regulated by NFYA but not c-Myc. Demethylation of the LIN28B-TST promoter might be a prerequisite for its transcription and transcriptional regulation. LIN28B-TST encodes a protein isoform with additional N-terminal amino acids and is critical for cancer cell proliferation and tumorigenesis. Our findings reveal a mechanism of LIN28B activation in cancer and the potential utility of LIN28B-TST for clinical purposes.
journal_name
Cell Repjournal_title
Cell reportsauthors
Guo W,Hu Z,Bao Y,Li Y,Li S,Zheng Q,Lyu D,Chen D,Yu T,Li Y,Zhu X,Ding J,Zhao Y,He X,Huang Sdoi
10.1016/j.celrep.2018.02.002subject
Has Abstractpub_date
2018-02-20 00:00:00pages
2016-2025issue
8issn
2211-1247pii
S2211-1247(18)30157-8journal_volume
22pub_type
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