Abstract：
:Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived Mϕs. Here, we further refine DC/Mϕ cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with Mϕ phenotype but functional DC features, including cross-presentation.
journal_name
Cell Repjournal_title
Cell reportsauthors
Sheng J,Chen Q,Soncin I,Ng SL,Karjalainen K,Ruedl Cdoi
10.1016/j.celrep.2017.10.024subject
Has Abstractpub_date
2017-10-31 00:00:00pages
1203-1214issue
5issn
2211-1247pii
S2211-1247(17)31456-0journal_volume
21pub_type
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