Tumor suppression by p53: is apoptosis important or not?

abstract：:Protein-coding genes undergo a wide array of regulatory interactions with factors that engage non-coding regions. Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding a major role in gene regulation. Here, we explore Piwi-interacting (pi)RNA-mediated transgene silencing...

journal_title：Cell reports

authors： Seth M,Shirayama M,Tang W,Shen EZ,Tu S,Lee HC,Weng Z,Mello CC

更新日期：2018-02-27 00:00:00

abstract：:We provide a catalog for the effects of the human kinome on cell survival in response to DNA-damaging agents, covering all major DNA repair pathways. By treating 313 kinase-deficient cell lines with ten diverse DNA-damaging agents, including seven commonly used chemotherapeutics, we identified examples of vulnerabilit...

journal_title：Cell reports

authors： Owusu M,Bannauer P,Ferreira da Silva J,Mourikis TP,Jones A,Májek P,Caldera M,Wiedner M,Lardeau CH,Mueller AC,Menche J,Kubicek S,Ciccarelli FD,Loizou JI

更新日期：2019-01-15 00:00:00

abstract：:The twin-ATPase ABCE1 has a vital function in mRNA translation by recycling terminated or stalled ribosomes. As for other functionally distinct ATP-binding cassette (ABC) proteins, the mechanochemical coupling of ATP hydrolysis to conformational changes remains elusive. Here, we use an integrated biophysical approach ...

journal_title：Cell reports

authors： Gouridis G,Hetzert B,Kiosze-Becker K,de Boer M,Heinemann H,Nürenberg-Goloub E,Cordes T,Tampé R

更新日期：2019-07-16 00:00:00

abstract：:The centromere binding factor 3 (CBF3) complex binds the third centromere DNA element in organisms with point centromeres, such as S. cerevisiae. It is an essential complex for assembly of the kinetochore in these organisms, as it facilitates genetic centromere specification and allows association of all other kinetoc...

journal_title：Cell reports

authors： Zhang W,Lukoyanova N,Miah S,Lucas J,Vaughan CK

更新日期：2018-07-17 00:00:00

abstract：:Proprioception, the sense of limb and body position, is essential for generating proper movement. Unconscious proprioceptive information travels through cerebellar-projecting neurons in the spinal cord and medulla. The progenitor domain defined by the basic-helix-loop-helix (bHLH) transcription factor, ATOH1, has been...

journal_title：Cell reports

authors： Yuengert R,Hori K,Kibodeaux EE,McClellan JX,Morales JE,Huang TP,Neul JL,Lai HC

更新日期：2015-11-10 00:00:00

abstract：:Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to severe ETC dysfunction when inactivated, we performed a genome-wide ge...

journal_title：Cell reports

authors： Chen WW,Birsoy K,Mihaylova MM,Snitkin H,Stasinski I,Yucel B,Bayraktar EC,Carette JE,Clish CB,Brummelkamp TR,Sabatini DD,Sabatini DM

更新日期：2014-04-10 00:00:00

abstract：:The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2 are recruited to target sites in vertebrate cells are not well understood. Building on recent studies that determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that, in methylation-deficient emb...

journal_title：Cell reports

authors： Cooper S,Dienstbier M,Hassan R,Schermelleh L,Sharif J,Blackledge NP,De Marco V,Elderkin S,Koseki H,Klose R,Heger A,Brockdorff N

更新日期：2014-06-12 00:00:00

abstract：:Complex architectural rearrangements are associated to the control of the HoxD genes in different cell types; yet, how they are implemented in single cells remains unknown. By use of polymer models, we dissect the locus 3D structure at the single DNA molecule level in mouse embryonic stem and cortical neuronal cells, ...

journal_title：Cell reports

authors： Bianco S,Annunziatella C,Andrey G,Chiariello AM,Esposito A,Fiorillo L,Prisco A,Conte M,Campanile R,Nicodemi M

更新日期：2019-08-06 00:00:00

abstract：:Brain function is compromised in myotonic dystrophy type 1 (DM1), but the underlying mechanisms are not fully understood. To gain insight into the cellular and molecular pathways primarily affected, we studied a mouse model of DM1 and brains of adult patients. We found pronounced RNA toxicity in the Bergmann glia of t...

journal_title：Cell reports

authors： Sicot G,Servais L,Dinca DM,Leroy A,Prigogine C,Medja F,Braz SO,Huguet-Lachon A,Chhuon C,Nicole A,Gueriba N,Oliveira R,Dan B,Furling D,Swanson MS,Guerrera IC,Cheron G,Gourdon G,Gomes-Pereira M

更新日期：2017-06-27 00:00:00

abstract：:Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on the virus and their immunogenicity are poorly understood. Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocap...

journal_title：Cell reports

authors： Lu S,Xie XX,Zhao L,Wang B,Zhu J,Yang TR,Yang GW,Ji M,Lv CP,Xue J,Dai EH,Fu XM,Liu DQ,Zhang L,Hou SJ,Yu XL,Wang YL,Gao HX,Shi XH,Ke CW,Ke BX,Jiang CG,Liu RT

更新日期：2021-01-26 00:00:00

abstract：:The plasma membrane (PM) forms extensive close junctions with the cortical endoplasmic reticulum (cER) in many cell types, ranging from yeast to mammals. How cells modulate structural plasticity of ER-PM contacts to accommodate space-demanding cortical events is largely unknown. Here, we report a role for eisosome-dri...

journal_title：Cell reports

authors： Ng AQE,Ng AYE,Zhang D

更新日期：2020-02-04 00:00:00

abstract：:The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years. How both pathways communicate and control liver metabolic functions are largely unknown. Detecting core components of Wnt and Hh signaling and mathematical...

journal_title：Cell reports

authors： Kolbe E,Aleithe S,Rennert C,Spormann L,Ott F,Meierhofer D,Gajowski R,Stöpel C,Hoehme S,Kücken M,Brusch L,Seifert M,von Schoenfels W,Schafmayer C,Brosch M,Hofmann U,Damm G,Seehofer D,Hampe J,Gebhardt R,Matz-Soja M

更新日期：2019-12-24 00:00:00

abstract：:Impulses generated by a multicellular, bioelectric signaling center termed the sinoatrial node (SAN) stimulate the rhythmic contraction of the heart. The SAN consists of a network of electrochemically oscillating pacemaker cells encased in a heterogeneous connective tissue microenvironment. Although the cellular compo...

journal_title：Cell reports

authors： Bressan M,Henley T,Louie JD,Liu G,Christodoulou D,Bai X,Taylor J,Seidman CE,Seidman JG,Mikawa T

更新日期：2018-05-22 00:00:00

abstract：:RIP1 is a central mediator of cell death in response to cell stress but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 acts as a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is coexpressed with EGFRWT in glioblastoma multiforme (GBM). EGFRvIII rec...

journal_title：Cell reports

authors： Puliyappadamba VT,Chakraborty S,Chauncey SS,Li L,Hatanpaa KJ,Mickey B,Noorani S,Shu HK,Burma S,Boothman DA,Habib AA

更新日期：2013-08-29 00:00:00

abstract：:Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messe...

journal_title：Cell reports

authors： Sinturel F,Navickas A,Wery M,Descrimes M,Morillon A,Torchet C,Benard L

更新日期：2015-09-22 00:00:00

abstract：:Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such changes are detected is not well understood. We identify the HSP70 chaperone as a sensor of changes in...

journal_title：Cell reports

authors： Bailly AP,Perrin A,Serrano-Macia M,Maghames C,Leidecker O,Trauchessec H,Martinez-Chantar ML,Gartner A,Xirodimas DP

更新日期：2019-10-01 00:00:00

abstract：:Recurrent epidemics of drug-resistant Staphylococcus aureus illustrate the rapid lapse of antibiotic efficacy following clinical implementation. Over the last decade, community-associated methicillin-resistant S. aureus (MRSA) has emerged as a dominant cause of infections, and this problem is amplified by the hyper-vi...

journal_title：Cell reports

authors： Parlet CP,Kavanaugh JS,Crosby HA,Raja HA,El-Elimat T,Todd DA,Pearce CJ,Cech NB,Oberlies NH,Horswill AR

更新日期：2019-04-02 00:00:00

abstract：:To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a variety of viruses. Aside from HIV-2 and the related simian immunodeficiency v...

journal_title：Cell reports

authors： Zhang K,Lv DW,Li R

更新日期：2019-07-09 00:00:00

abstract：:Activation of the transcription factor NF-κB is essential for innate immune function and requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc deficiency is associated with elevated inflammation and worse outcomes in response to bacterial infection and sepsis. Previous studies sugg...

journal_title：Cell reports

authors： Liu MJ,Bao S,Gálvez-Peralta M,Pyle CJ,Rudawsky AC,Pavlovicz RE,Killilea DW,Li C,Nebert DW,Wewers MD,Knoell DL

更新日期：2013-02-21 00:00:00

abstract：:Nono is a component of the para-speckle, which stores and processes RNA. Mouse embryonic stem cells (mESCs) lack para-speckles, leaving the function of Nono in mESCs unclear. Here, we find that Nono functions as a chromatin regulator cooperating with Erk to regulate mESC pluripotency. We report that Nono loss results ...

journal_title：Cell reports

authors： Ma C,Karwacki-Neisius V,Tang H,Li W,Shi Z,Hu H,Xu W,Wang Z,Kong L,Lv R,Fan Z,Zhou W,Yang P,Wu F,Diao J,Tan L,Shi YG,Lan F,Shi Y

更新日期：2016-10-18 00:00:00

abstract：:The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was contradicted by the identification of capped transcripts missing portions of their 5' ends and a cytoplasmic complex that can restore the cap on uncapped mRNAs. In this study, we used accumulation of uncapped transcripts in cells inhibited ...

journal_title：Cell reports

authors： Mukherjee C,Patil DP,Kennedy BA,Bakthavachalu B,Bundschuh R,Schoenberg DR

更新日期：2012-09-27 00:00:00

abstract：:Vitamin D (VD) is a known differentiating agent, but the role of VD receptor (VDR) is still incompletely described in acute myeloid leukemia (AML), whose treatment is based mostly on antimitotic chemotherapy. Here, we present an unexpected role of VDR in normal hematopoiesis and in leukemogenesis. Limited VDR expressi...

journal_title：Cell reports

authors： Paubelle E,Zylbersztejn F,Maciel TT,Carvalho C,Mupo A,Cheok M,Lieben L,Sujobert P,Decroocq J,Yokoyama A,Asnafi V,Macintyre E,Tamburini J,Bardet V,Castaigne S,Preudhomme C,Dombret H,Carmeliet G,Bouscary D,Ginzburg YZ

更新日期：2020-01-21 00:00:00

abstract：:GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we examined the Ca2+ sensor of exocytosis at GABAergic basket cell (BC) to Pu...

journal_title：Cell reports

authors： Chen C,Arai I,Satterfield R,Young SM Jr,Jonas P

更新日期：2017-01-17 00:00:00

abstract：:MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells follow...

journal_title：Cell reports

authors： Chen Z,Stelekati E,Kurachi M,Yu S,Cai Z,Manne S,Khan O,Yang X,Wherry EJ

更新日期：2017-09-12 00:00:00

abstract：:The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available. We report here our attempt to generate such reagents: monoclonal antibodies against the most common R175H, ...

journal_title：Cell reports

authors： Hwang LA,Phang BH,Liew OW,Iqbal J,Koh XH,Koh XY,Othman R,Xue Y,Richards AM,Lane DP,Sabapathy K

更新日期：2018-01-02 00:00:00

abstract：:The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors. Here, we show that BDNF is a regulator of this balance and promotes neuroprotection by reducing toxic NMDA receptor signaling. BDNF acts by initiating syna...

journal_title：Cell reports

authors： Lau D,Bengtson CP,Buchthal B,Bading H

更新日期：2015-08-25 00:00:00

abstract：:The macrophage NLRC4 inflammasome drives potent innate immune responses against Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (e.g., interleukin-1β [IL-1β]) and pyroptotic cell death. However, the potential contribution of other cell types to inflammasome-mediated host defense against...

journal_title：Cell reports

authors： Chen KW,Groß CJ,Sotomayor FV,Stacey KJ,Tschopp J,Sweet MJ,Schroder K

更新日期：2014-07-24 00:00:00

abstract：:Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...

journal_title：Cell reports

authors： Moore AR,Ran L,Guan Y,Sher JJ,Hitchman TD,Zhang JQ,Hwang C,Walzak EG,Shoushtari AN,Monette S,Murali R,Wiesner T,Griewank KG,Chi P,Chen Y

更新日期：2018-02-27 00:00:00

abstract：:Effector, but not naïve, T cells are activated by toll-like receptor-2 (TLR2) stimulation, leading to cytokine production and proliferation. We found that the differential response is attributable to the lack of expression of the adaptor protein TIRAP in naive T cells. TIRAP expression is induced upon T-cell receptor ...

journal_title：Cell reports

authors： Imanishi T,Unno M,Kobayashi W,Yoneda N,Akira S,Saito T

更新日期：2020-07-21 00:00:00

abstract：:Cilia mediate Hedgehog (Hh) signaling in vertebrates and Hh deregulation results in several clinical manifestations, such as obesity, cognitive disabilities, developmental malformations, and various cancers. Drosophila cells are nonciliated during development, which has led to the assumption that cilia-mediated Hh sig...

journal_title：Cell reports

authors： Kuzhandaivel A,Schultz SW,Alkhori L,Alenius M

更新日期：2014-05-08 00:00:00