当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.

The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.

Abstract：

:To understand how the Bcl6 transcriptional repressor functions in the immune system, we disrupted its RD2 repression domain in mice. Bcl6RD2(MUT) mice exhibit a complete loss of germinal center (GC) formation but retain normal extrafollicular responses. Bcl6RD2(MUT) antigen-engaged B cells migrate to the interfollicular zone and interact with cognate T helper cells. However, these cells fail to complete early GC-commitment differentiation and coalesce as nascent GC aggregates. Bcl6 directly binds and represses trafficking receptors S1pr1 and Gpr183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B cell migration and may contribute to GC failure in Bcl6RD2(MUT) mice. The development of functional GC-TFH cells was partially impaired in Bcl6RD2(MUT) mice. In contrast to Bcl6(-/-) mice, Bcl6RD2(MUT) animals experience no inflammatory disease or macrophage deregulation. These results reveal an essential role for RD2 repression in early GC commitment and striking biochemical specificity in Bcl6 control of humoral and innate immune-cell phenotypes.

journal_name

Cell Rep

journal_title

Cell reports

authors

Huang C,Gonzalez DG,Cote CM,Jiang Y,Hatzi K,Teater M,Dai K,Hla T,Haberman AM,Melnick A

doi

10.1016/j.celrep.2014.07.059

subject

Has Abstract

pub_date

2014-09-11 00:00:00

pages

1497-508

issue

5

issn

2211-1247

pii

S2211-1247(14)00662-7

journal_volume

8

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.

    abstract：:Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precisely how these phenomena are linked, however, remains unclear. Using a cortico-hip...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107865

    authors： Agasse F,Mendez-David I,Christaller W,Carpentier R,Braz BY,David DJ,Saudou F,Humbert S

    更新日期：2020-07-07 00:00:00

  • The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment.

    abstract：:Nephrons, the functional units of the kidney, develop from progenitor cells (cap mesenchyme [CM]) surrounding the epithelial ureteric bud (UB) tips. Reciprocal signaling between UB and CM induces nephrogenesis and UB branching. Although low nephron number is implicated in hypertension and renal disease, the mechanisms...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.02.033

    authors： Cebrian C,Asai N,D'Agati V,Costantini F

    更新日期：2014-04-10 00:00:00

  • Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage.

    abstract：:Understanding how antibiotics impact bacterial metabolism may provide insight into their mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we profiled the metabolome of Escherichia coli after treatment with three different classes of bactericidal antibiotics (?-lactams, aminoglycosides, ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.09.059

    authors： Belenky P,Ye JD,Porter CB,Cohen NR,Lobritz MA,Ferrante T,Jain S,Korry BJ,Schwarz EG,Walker GC,Collins JJ

    更新日期：2015-11-03 00:00:00

  • Spontaneous Vesicle Fusion Is Differentially Regulated at Cholinergic and GABAergic Synapses.

    abstract：:The locomotion of C. elegans is balanced by excitatory and inhibitory neurotransmitter release at neuromuscular junctions. However, the molecular mechanisms that maintain the balance of synaptic transmission remain enigmatic. Here, we investigated the function of voltage-gated Ca2+ channels in triggering spontaneous r...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.023

    authors： Liu H,Li L,Wang W,Gong J,Yang X,Hu Z

    更新日期：2018-02-27 00:00:00

  • 5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells.

    abstract：:5-methylcytosine (5mC) is converted to 5-hydroxymethylcytosine (5hmC) by the TET family of enzymes as part of a recently discovered active DNA de-methylation pathway. 5hmC plays important roles in regulation of gene expression and differentiation and has been implicated in T cell malignancies and autoimmunity. Here, w...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.05.091

    authors： Nestor CE,Lentini A,Hägg Nilsson C,Gawel DR,Gustafsson M,Mattson L,Wang H,Rundquist O,Meehan RR,Klocke B,Seifert M,Hauck SM,Laumen H,Zhang H,Benson M

    更新日期：2016-07-12 00:00:00

  • MetaCyto: A Tool for Automated Meta-analysis of Mass and Flow Cytometry Data.

    abstract：:While meta-analysis has demonstrated increased statistical power and more robust estimations in studies, the application of this commonly accepted methodology to cytometry data has been challenging. Different cytometry studies often involve diverse sets of markers. Moreover, the detected values of the same marker are ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.003

    authors： Hu Z,Jujjavarapu C,Hughey JJ,Andorf S,Lee HC,Gherardini PF,Spitzer MH,Thomas CG,Campbell J,Dunn P,Wiser J,Kidd BA,Dudley JT,Nolan GP,Bhattacharya S,Butte AJ

    更新日期：2018-07-31 00:00:00

  • isoTarget: A Genetic Method for Analyzing the Functional Diversity of Splicing Isoforms In Vivo.

    abstract：:Protein isoforms generated by alternative splicing contribute to proteome diversity. Because of the lack of effective techniques, the isoform-specific function, expression, localization, and signaling of endogenous proteins are unknown for most genes. Here, we report a genetic method, isoTarget, for multi-purpose stud...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108361

    authors： Liu H,Pizzano S,Li R,Zhao W,Veling MW,Hu Y,Yang L,Ye B

    更新日期：2020-11-10 00:00:00

  • The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge.

    abstract：:The macrophage NLRC4 inflammasome drives potent innate immune responses against Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (e.g., interleukin-1β [IL-1β]) and pyroptotic cell death. However, the potential contribution of other cell types to inflammasome-mediated host defense against...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.028

    authors： Chen KW,Groß CJ,Sotomayor FV,Stacey KJ,Tschopp J,Sweet MJ,Schroder K

    更新日期：2014-07-24 00:00:00

  • RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly.

    abstract：:The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflammatory disorders, inc...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108405

    authors： Duan Y,Zhang L,Angosto-Bazarra D,Pelegrín P,Núñez G,He Y

    更新日期：2020-11-17 00:00:00

  • Growth of B Cell Receptor Microclusters Is Regulated by PIP2 and PIP3 Equilibrium and Dock2 Recruitment and Activation.

    abstract：:The growth of B cell receptor (BCR) microclusters upon antigen stimulation drives B cell activation. Here, we show that PI3K-mediated PIP3 production is required for the growth of BCR microclusters. This growth is likely inhibited by PTEN and dependent on its plasma membrane binding and lipid phosphatase activities. M...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.10.117

    authors： Wang J,Xu L,Shaheen S,Liu S,Zheng W,Sun X,Li Z,Liu W

    更新日期：2017-11-28 00:00:00

  • Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.

    abstract：:Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis, disruptions of which can lead to metabolic diseases. Whether N6-methyladenosine (m6A) mRNA methylation impacts circadian regulation of lipid metabolism is unclear. Here, we show m6A mRNA methylation oscillations in murine liv...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.068

    authors： Zhong X,Yu J,Frazier K,Weng X,Li Y,Cham CM,Dolan K,Zhu X,Hubert N,Tao Y,Lin F,Martinez-Guryn K,Huang Y,Wang T,Liu J,He C,Chang EB,Leone V

    更新日期：2018-11-13 00:00:00

  • VCP Machinery Mediates Autophagic Degradation of Empty Argonaute.

    abstract：:The Argonaute subfamily of proteins (AGO) loads microRNAs (miRNAs) to form the effector complex that mediates target gene silencing. Empty AGO, but not miRNA-loaded AGO, is selectively degraded across species. We have reported that the degradation of empty AGO is part of a quality control pathway that eliminates dysfu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.07.003

    authors： Kobayashi H,Shoji K,Kiyokawa K,Negishi L,Tomari Y

    更新日期：2019-07-30 00:00:00

  • Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling.

    abstract：:Effective approaches to neuropsychiatric disorders require detailed understanding of the cellular composition and circuitry of the complex mammalian brain. Here, we present a paradigm for deconstructing the diversity of neurons defined by a specific neurotransmitter using a microfluidic dynamic array to simultaneously...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.10.008

    authors： Poulin JF,Zou J,Drouin-Ouellet J,Kim KY,Cicchetti F,Awatramani RB

    更新日期：2014-11-06 00:00:00

  • Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection.

    abstract：:Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. Here, we demonstrate that the loss of CD4 Th1 cells specifically leads to progressive CD8 T cell decline and dysfunction during viral p...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.08.065

    authors： Snell LM,Osokine I,Yamada DH,De la Fuente JR,Elsaesser HJ,Brooks DG

    更新日期：2016-09-20 00:00:00

  • Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment.

    abstract：:Breast cancer stem cells (BCSCs) play a critical role in tumor recurrence and metastasis. Exposure of breast cancer cells to chemotherapy leads to an enrichment of BCSCs. Here, we find that chemotherapy induces the expression of glutathione S-transferase omega 1 (GSTO1), which is dependent on hypoxia-inducible factor ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.02.001

    authors： Lu H,Chen I,Shimoda LA,Park Y,Zhang C,Tran L,Zhang H,Semenza GL

    更新日期：2017-02-21 00:00:00

  • Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation.

    abstract：:Megakaryocytes (MKs) come from a complex process of hematopoietic progenitor maturation within the bone marrow that gives rise to de novo circulating platelets. Bone marrow microenvironment contains a large number of adipocytes with a still ill-defined role. This study aims to analyze the influence of adipocytes and i...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107875

    authors： Valet C,Batut A,Vauclard A,Dortignac A,Bellio M,Payrastre B,Valet P,Severin S

    更新日期：2020-07-07 00:00:00

  • Allosteric Regulation of NCLX by Mitochondrial Membrane Potential Links the Metabolic State and Ca2+ Signaling in Mitochondria.

    abstract：:Calcium is a key regulator of mitochondrial function under both normal and pathological conditions. The mechanisms linking metabolic activity to mitochondrial Ca2+ signaling remain elusive, however. Here, by monitoring mitochondrial Ca2+ transients while manipulating mitochondrial membrane potential (ΔΨm), we found th...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.11.084

    authors： Kostic M,Katoshevski T,Sekler I

    更新日期：2018-12-18 00:00:00

  • Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning.

    abstract：:The role of neurotrophic factors as endogenous survival proteins for brain neurons remains contentious. In the cerebellum, the signals controlling survival of molecular layer interneurons (MLIs) are unknown, and direct evidence for the requirement of a full complement of MLIs for normal cerebellar function and motor l...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.05.030

    authors： Sergaki MC,López-Ramos JC,Stagkourakis S,Gruart A,Broberger C,Delgado-García JM,Ibáñez CF

    更新日期：2017-06-06 00:00:00

  • Opiates modulate thermosensation by internalizing cold receptor TRPM8.

    abstract：:Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests itself with severe symptoms, including cold hyperalgesia, often preventing addicted patients from successfully completing the rehabi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.07.002

    authors： Shapovalov G,Gkika D,Devilliers M,Kondratskyi A,Gordienko D,Busserolles J,Bokhobza A,Eschalier A,Skryma R,Prevarskaya N

    更新日期：2013-08-15 00:00:00

  • Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics.

    abstract：:Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and drive wound healing. Previous studies have probed basal cell heterogeneity in stem and progenitor potential, but a comprehensive dissection of ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.02.091

    authors： Haensel D,Jin S,Sun P,Cinco R,Dragan M,Nguyen Q,Cang Z,Gong Y,Vu R,MacLean AL,Kessenbrock K,Gratton E,Nie Q,Dai X

    更新日期：2020-03-17 00:00:00

  • Data-Driven Modeling of Intracellular Auxin Fluxes Indicates a Dominant Role of the ER in Controlling Nuclear Auxin Uptake.

    abstract：:In plants, the phytohormone auxin acts as a master regulator of developmental processes and environmental responses. The best characterized process in the auxin regulatory network occurs at the subcellular scale, wherein auxin mediates signal transduction into transcriptional programs by triggering the degradation of ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.074

    authors： Middleton AM,Dal Bosco C,Chlap P,Bensch R,Harz H,Ren F,Bergmann S,Wend S,Weber W,Hayashi KI,Zurbriggen MD,Uhl R,Ronneberger O,Palme K,Fleck C,Dovzhenko A

    更新日期：2018-03-13 00:00:00

  • Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.

    abstract：:Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show that the endonuclease Regnase-1 is critical for the degradation ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.05.009

    authors： Yoshinaga M,Nakatsuka Y,Vandenbon A,Ori D,Uehata T,Tsujimura T,Suzuki Y,Mino T,Takeuchi O

    更新日期：2017-05-23 00:00:00

  • Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array.

    abstract：:As three-dimensional cell culture formats gain in popularity, there emerges a need for tools that produce vast amounts of data on individual cells within the spheroids or organoids. Here, we present a microfluidic platform that provides access to such data by parallelizing the manipulation of individual spheroids with...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107670

    authors： Tomasi RF,Sart S,Champetier T,Baroud CN

    更新日期：2020-05-26 00:00:00

  • Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes.

    abstract：:Genetically encoded effectors are important tools for probing cellular function in living animals, but improved methods for directing their expression to specific cell types are required. Here, we introduce a simple, versatile method for achieving cell-type-specific expression of transgenes that leverages the untapped...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.01.059

    authors： Diao F,Ironfield H,Luan H,Diao F,Shropshire WC,Ewer J,Marr E,Potter CJ,Landgraf M,White BH

    更新日期：2015-03-03 00:00:00

  • Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.

    abstract：:Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer (NK)...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.07.021

    authors： Huang X,Li J,Dorta-Estremera S,Di Domizio J,Anthony SM,Watowich SS,Popkin D,Liu Z,Brohawn P,Yao Y,Schluns KS,Lanier LL,Cao W

    更新日期：2015-08-18 00:00:00

  • ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.

    abstract：:Glioblastoma (GBM) harbors subpopulations of therapy-resistant tumor-initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397 kDa transcription factor. ZFHX4 is ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.12.032

    authors： Chudnovsky Y,Kim D,Zheng S,Whyte WA,Bansal M,Bray MA,Gopal S,Theisen MA,Bilodeau S,Thiru P,Muffat J,Yilmaz OH,Mitalipova M,Woolard K,Lee J,Nishimura R,Sakata N,Fine HA,Carpenter AE,Silver SJ,Verhaak RG,Califano

    更新日期：2014-01-30 00:00:00

  • Cytoplasmic Control of Sense-Antisense mRNA Pairs.

    abstract：:Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messe...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.08.016

    authors： Sinturel F,Navickas A,Wery M,Descrimes M,Morillon A,Torchet C,Benard L

    更新日期：2015-09-22 00:00:00

  • RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells.

    abstract：:Development and function of pancreatic β cells involve the regulated activity of specific transcription factors. RFX6 is a transcription factor essential for mouse β cell differentiation that is mutated in monogenic forms of neonatal diabetes. However, the expression and functional roles of RFX6 in human β cells, espe...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.11.010

    authors： Chandra V,Albagli-Curiel O,Hastoy B,Piccand J,Randriamampita C,Vaillant E,Cavé H,Busiah K,Froguel P,Vaxillaire M,Rorsman P,Polak M,Scharfmann R

    更新日期：2014-12-24 00:00:00

  • Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression.

    abstract：:Synaptic efficacy plays crucial roles in neuronal circuit operation and synaptic plasticity. Presynaptic determinants of synaptic efficacy are neurotransmitter content in synaptic vesicles and the number of vesicles undergoing exocytosis at a time. Bursts of presynaptic firings depress synaptic efficacy, mainly due to...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.080

    authors： Yamashita M,Kawaguchi SY,Hori T,Takahashi T

    更新日期：2018-03-20 00:00:00

  • Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System.

    abstract：:Systemic immune dysregulation contributes to the development of neuropsychiatric and neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on myeloid cells across anatomical brain regions is unclear. Here, we demonstrate brain-region-specific differences in myeloid responses induced b...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.02.109

    authors： Süß P,Hoffmann A,Rothe T,Ouyang Z,Baum W,Staszewski O,Schett G,Prinz M,Krönke G,Glass CK,Winkler J,Schlachetzki JCM

    更新日期：2020-03-24 00:00:00