Abstract：
:Systemic immune dysregulation contributes to the development of neuropsychiatric and neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on myeloid cells across anatomical brain regions is unclear. Here, we demonstrate brain-region-specific differences in myeloid responses induced by chronic peripheral inflammation. This shift in the myeloid compartment is associated with the appearance of an inflammatory myeloid subpopulation in the cortex, striatum, and thalamus accompanied by regional transcriptomic fingerprints that include induction of chemokines, complement factors, and endothelial adhesion molecules. In contrast, myeloid immune responses within the hippocampus and cerebellum are subtle or absent. Treatment with the anti-tumor necrosis factor α (anti-TNF-α) antibody infliximab ablates the region-specific inflammatory response. A region-specific myeloid cell response to chronic peripheral inflammation is observed in postmortem brains from individuals with rheumatoid arthritis. Our data suggest that chronic peripheral inflammation has heterogeneous effects on the brain, as evidenced by the spectrum of myeloid cell responses observed across brain regions.
journal_name
Cell Repjournal_title
Cell reportsauthors
Süß P,Hoffmann A,Rothe T,Ouyang Z,Baum W,Staszewski O,Schett G,Prinz M,Krönke G,Glass CK,Winkler J,Schlachetzki JCMdoi
10.1016/j.celrep.2020.02.109subject
Has Abstractpub_date
2020-03-24 00:00:00pages
4082-4095.e6issue
12issn
2211-1247pii
S2211-1247(20)30290-4journal_volume
30pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of Id genes in adult ECs results in dilated, leaky sinusoids and a pro-inflammatory state that increases in severity ov...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107572
更新日期：2020-04-28 00:00:00
abstract：:Chromatin interactions play important roles in transcription regulation. To better understand the underlying evolutionary and functional constraints of these interactions, we implemented a systems approach to examine RNA polymerase-II-associated chromatin interactions in human cells. We found that 40% of the total gen...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.09.022
更新日期：2012-11-29 00:00:00
abstract：:RNA polymerase II transcripts receive a protective 5',5'-triphosphate-linked 7-methylguanosine (m7G) cap, and its removal by decapping enzymes like DCP2 is critical for initiation of RNA decay. Alternative RNA caps can be acquired when transcription initiation uses metabolites like nicotinamide adenine dinucleotide (N...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.11.108
更新日期：2019-12-24 00:00:00
abstract：:Shelterin is a six-subunit protein complex that plays crucial roles in telomere length regulation, protection, and maintenance. Although several shelterin subunits have been studied in vitro, the biochemical properties of the fully assembled shelterin complex are not well defined. Here, we characterize shelterin using...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.12.005
更新日期：2017-01-03 00:00:00
abstract：:Despite recent progress in engineering native trimeric HIV-1 envelope glycoprotein (Env) mimics as vaccine candidates, Env trimers often induce vaccine-matched neutralizing antibody (NAb) responses. Understanding the specificities of autologous NAb responses and the underlying molecular mechanisms restricting the neut...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.039
更新日期：2019-04-09 00:00:00
abstract：:Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the s...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.087
更新日期：2018-04-17 00:00:00
abstract：:Brain function is compromised in myotonic dystrophy type 1 (DM1), but the underlying mechanisms are not fully understood. To gain insight into the cellular and molecular pathways primarily affected, we studied a mouse model of DM1 and brains of adult patients. We found pronounced RNA toxicity in the Bergmann glia of t...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.06.006
更新日期：2017-06-27 00:00:00
abstract：:Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos. During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygotic epigenome. Here, we demonstrate that Xenopus laevis Npm post-tran...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.02.038
更新日期：2015-03-17 00:00:00
abstract：:Human cells contain five canonical, replication-dependent somatic histone H1 subtypes (H1.1, H1.2, H1.3, H1.4, and H1.5). Although they are key chromatin components, the genomic distribution of the H1 subtypes is still unknown, and their role in chromatin processes has thus far remained elusive. Here, we map the genom...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.05.003
更新日期：2013-06-27 00:00:00
abstract：:Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+ (DP) thymocytes. While RORγ antagonists are currently being developed t...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.11.073
更新日期：2016-12-20 00:00:00
abstract：:Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases. This provides the rationale for HSP90 inhibitors as cancer therapeutics. However, the mechanism by which HSP90 ATPase inhibition triggers ubiqu...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.05.078
更新日期：2017-06-20 00:00:00
abstract：:Huntington's disease (HD) is a monogenic neurodegenerative disorder representing an ideal candidate for gene silencing with oligonucleotide therapeutics (i.e., antisense oligonucleotides [ASOs] and small interfering RNAs [siRNAs]). Using an ultra-sensitive branched fluorescence in situ hybridization (FISH) method, we ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.07.106
更新日期：2018-09-04 00:00:00
abstract：:Working memory is mediated by the coordinated activation of frontal and parietal cortices occurring in the theta and alpha frequency ranges. Here, we test whether electrically stimulating frontal and parietal regions at the frequency of interaction is effective in modulating working memory. We identify working memory ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.10.072
更新日期：2019-11-26 00:00:00
abstract：:Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.09.072
更新日期：2016-10-11 00:00:00
abstract：:The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and tensin homolog (PTEN). Although a role for microRNA (miRNA)-dependent control of...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108436
更新日期：2020-12-01 00:00:00
abstract：:Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle. Cyclin-dependent kinase 1 (Cdk1) activates HR by phosphorylation of key recombination f...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.11.044
更新日期：2014-12-24 00:00:00
abstract：:The master regulatory transcription factor GATA-2 triggers hematopoietic stem and progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and GATA2 overexpression portends a poor prognosis for AML. However, the constituents of the GATA-2-de...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.07.058
更新日期：2016-08-30 00:00:00
abstract：:Small cytoplasmic mRNP granules are implicated in mRNA transport, translational control, and decay. Using super-resolution microscopy and fluorescence correlation spectroscopy, we analyzed the molecular composition and dynamics of single cytoplasmic YBX1_IMP1 mRNP granules in live cells. Granules appeared elongated an...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.09.018
更新日期：2019-10-15 00:00:00
abstract：:A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study the origin of novelties because mammals preserve stages in the...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.12.052
更新日期：2015-02-03 00:00:00
abstract：:PARP1 plays a critical role in regulating many biological processes linked to cellular stress responses. Although DNA strand breaks are potent stimuli of PARP1 enzymatic activity, the context-dependent mechanism regulating PARP1 activation and signaling is poorly understood. We performed global characterization of the...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.106
更新日期：2017-11-21 00:00:00
abstract：:At presynaptic active zones, exocytosis of neurotransmitter vesicles (SVs) is driven by SNARE complexes that recruit Syb2 and SNAP25. However, it remains unknown which SNAREs promote the secretion of neuronal proteins, including those essential for circuit development and experience-dependent plasticity. Here we demon...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.04.032
更新日期：2015-05-19 00:00:00
abstract：:Cancer is often seen as a disease of mutations and chromosomal abnormalities. However, some cancers, including pediatric rhabdoid tumors (RTs), lack recurrent alterations targetable by current drugs and need alternative, informed therapeutic options. To nominate potential targets, we performed a high-throughput small-...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.021
更新日期：2019-08-27 00:00:00
abstract：:Plant glutamate receptor homologs (GLRs) have long been proposed to function as ligand-gated Ca2+ channels, but no in planta evidence has been provided. Here, we present genetic evidence that Arabidopsis GLR3.1 and GLR3.5 form Ca2+ channels activated by L-methionine (L-Met) at physiological concentrations and regulate...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.11.015
更新日期：2016-12-06 00:00:00
abstract：:The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close prox...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.08.007
更新日期：2017-08-22 00:00:00
abstract：:Training-dependent increases in c-fos have been used to identify engram cells encoding long-term memories (LTMs). However, the interaction between transcription factors required for LTM, including CREB and c-Fos, and activating kinases such as phosphorylated ERK (pERK) in the establishment of memory engrams has been u...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.11.022
更新日期：2018-12-04 00:00:00
abstract：:Lung disease is a major cause of death in the United States, with current therapeutic approaches serving only to manage symptoms. The most common chronic and life-threatening genetic disease of the lung is cystic fibrosis (CF) caused by mutations in the cystic fibrosis transmembrane regulator (CFTR). We have generated...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.07.062
更新日期：2015-09-01 00:00:00
abstract：:Genetic and clinical association studies have identified disrupted in schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family in which the translocation predisposes to psychiatric disorders. We investigate the consequenc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.07.061
更新日期：2015-09-01 00:00:00
abstract：:In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT5 receptor, DRL (derailed), which is expressed in the dorsomedial lineages, bra...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.04.035
更新日期：2015-05-26 00:00:00
abstract：:Cytoplasmic long non-coding RNAs have been shown to act at many different levels to control post-transcriptional gene expression, although their role in translational control is poorly understood. Here, we show that lnc-31, a non-coding RNA required for myoblast proliferation, promotes ROCK1 protein synthesis by stabi...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.101
更新日期：2018-04-17 00:00:00
abstract：:Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of new unmodified histones during each cell cycle, and the principl...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.060
更新日期：2020-01-28 00:00:00
