The Long Non-coding RNA lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation.

Abstract:

:Cytoplasmic long non-coding RNAs have been shown to act at many different levels to control post-transcriptional gene expression, although their role in translational control is poorly understood. Here, we show that lnc-31, a non-coding RNA required for myoblast proliferation, promotes ROCK1 protein synthesis by stabilizing its translational activator, YB-1. We find that lnc-31 binds to the Rock1 mRNA as well as to the YB-1 protein and that translational activation requires physical interaction between the two RNA species. These results suggest a localized effect of YB-1 stabilization on the Rock1 mRNA. ROCK1 upregulation by lnc-31, in proliferative conditions, correlates well with the differentiation-repressing activity of ROCK1. We also show that, upon induction of differentiation, the downregulation of lnc-31, in conjunction with miR-152 targeting of Rock1, establishes a regulatory loop that reinforces ROCK1 repression and promotes myogenesis.

journal_name

Cell Rep

journal_title

Cell reports

authors

Dimartino D,Colantoni A,Ballarino M,Martone J,Mariani D,Danner J,Bruckmann A,Meister G,Morlando M,Bozzoni I

doi

10.1016/j.celrep.2018.03.101

subject

Has Abstract

pub_date

2018-04-17 00:00:00

pages

733-740

issue

3

issn

2211-1247

pii

S2211-1247(18)30477-7

journal_volume

23

pub_type

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