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Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.

Abstract：

:The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfbret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration.

journal_name

Cell Rep

journal_title

Cell reports

authors

De La Fuente AG,Lange S,Silva ME,Gonzalez GA,Tempfer H,van Wijngaarden P,Zhao C,Di Canio L,Trost A,Bieler L,Zaunmair P,Rotheneichner P,O'Sullivan A,Couillard-Despres S,Errea O,Mäe MA,Andrae J,He L,Keller A,Bátiz LF

doi

10.1016/j.celrep.2017.08.007

subject

Has Abstract

pub_date

2017-08-22 00:00:00

pages

1755-1764

issue

8

issn

2211-1247

pii

S2211-1247(17)31095-1

journal_volume

20

pub_type

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