Abstract：
:In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT5 receptor, DRL (derailed), which is expressed in the dorsomedial lineages, brain structure precursors adjacent to the MBs, is required for MB α branch axon guidance. DRL acts to capture and present WNT5 to MB axons rather than transduce a WNT5 signal. DRL's ectodomain must be cleaved and shed to guide α axons. DRL-2, another Ryk, is expressed within MB axons and functions as a repulsive WNT5 signaling receptor. Finally, our biochemical data support the existence of a ternary complex composed of the cleaved DRL ectodomain, WNT5, and DRL-2. Thus, the interaction of MB-extrinsic and -intrinsic Ryks via their common ligand acts to guide MB α axons.
journal_name
Cell Repjournal_title
Cell reportsauthors
Reynaud E,Lahaye LL,Boulanger A,Petrova IM,Marquilly C,Flandre A,Martianez T,Privat M,Noordermeer JN,Fradkin LG,Dura JMdoi
10.1016/j.celrep.2015.04.035subject
Has Abstractpub_date
2015-05-26 00:00:00pages
1293-304issue
8issn
2211-1247pii
S2211-1247(15)00436-2journal_volume
11pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:The MLL gene is a common target of chromosomal translocations found in human leukemia. MLL-fusion leukemia has a consistently poor outcome. One of the most common translocation partners is AF9 (MLLT3). MLL-AF9 recruits DOT1L, a histone 3 lysine 79 methyltransferase (H3K79me1/me2/me3), leading to aberrant gene transcri...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.04.004
更新日期：2015-05-05 00:00:00
abstract：:The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla (DP) cells are required for SC activation during the adult hair cycle, but signal exchange between niche and SC precursors/transit-amplif...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.078
更新日期：2016-03-29 00:00:00
abstract：:The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and tensin homolog (PTEN). Although a role for microRNA (miRNA)-dependent control of...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108436
更新日期：2020-12-01 00:00:00
abstract：:Complex architectural rearrangements are associated to the control of the HoxD genes in different cell types; yet, how they are implemented in single cells remains unknown. By use of polymer models, we dissect the locus 3D structure at the single DNA molecule level in mouse embryonic stem and cortical neuronal cells, ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.013
更新日期：2019-08-06 00:00:00
abstract：:Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) an...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.08.082
更新日期：2017-09-19 00:00:00
abstract：:The casein kinase 1 (CK1) family participates in various cellular processes in eukaryotes, but CK1 function in higher plants remains largely unknown. Here, we characterize the function of Arabidopsis CK1 in the regulation of ethylene biosynthesis. Etiolated seedlings of a CK1.8-deficient mutant, ck1.8-1, showed charac...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.10.047
更新日期：2014-12-11 00:00:00
abstract：:Recent evidence supports the presence of an L-glutamyl methyltransferase(s) in eukaryotic cells, but this enzyme class has been defined only in certain prokaryotic species. Here, we characterize the human C6orf211 gene product as "acidic residue methyltransferase-1" (Armt1), an enzyme that specifically targets prolife...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.01.054
更新日期：2015-03-03 00:00:00
abstract：:Systemic immune dysregulation contributes to the development of neuropsychiatric and neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on myeloid cells across anatomical brain regions is unclear. Here, we demonstrate brain-region-specific differences in myeloid responses induced b...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.109
更新日期：2020-03-24 00:00:00
abstract：:The asymmetric distribution of auxin leads to the bending growth of hypocotyls during gravitropic and phototropic responses, but the signaling events downstream of auxin remain unclear. Here, we identify many SAUR genes showing asymmetric expression in soybean hypocotyls during gravistimulation and then study their ho...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107529
更新日期：2020-04-21 00:00:00
abstract：:Memories are believed to be stored in distributed neuronal assemblies through activity-induced changes in synaptic and intrinsic properties. However, the specific mechanisms by which different memories become associated or linked remain a mystery. Here, we develop a simplified, biophysically inspired network model tha...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.10.015
更新日期：2016-11-01 00:00:00
abstract：:Epigenomic mechanisms direct distinct gene expression programs for different cell types. Various in vivo tissues have been subjected to epigenomic analysis; however, these studies have been limited by cellular heterogeneity, resulting in composite gene expression and epigenomic profiles. Here, we introduce "NuTRAP," a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.12.087
更新日期：2017-01-24 00:00:00
abstract：:Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in regulating the actomyosin network by suppressing Rho GTPase in medaka fish. Here, we identify Rho GTPase activating protein 29 (ARHGAP29) as a transc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.04.075
更新日期：2017-05-23 00:00:00
abstract：:Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene expression and DNA se...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.01.094
更新日期：2019-02-19 00:00:00
abstract：:Generating mammalian cells with desired mitochondrial DNA (mtDNA) sequences is enabling for studies of mitochondria, disease modeling, and potential regenerative therapies. MitoPunch, a high-throughput mitochondrial transfer device, produces cells with specific mtDNA-nuclear DNA (nDNA) combinations by transferring iso...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108562
更新日期：2020-12-29 00:00:00
abstract：:Infections can result in a temporarily restricted unresponsiveness of the innate immune response, thereby limiting pathogen control. Mechanisms of such unresponsiveness are well studied in lipopolysaccharide tolerance; however, whether mechanisms of tolerance limit innate immunity during virus infection remains unknow...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.101
更新日期：2020-03-17 00:00:00
abstract：:Cell growth is coupled to cell-cycle progression in mitotically proliferating mammalian cells, but the underlying molecular mechanisms are not well understood. CyclinD-Cdk4/6 is known to phosphorylate RB to promote S-phase entry, but recent work suggests they have additional functions. We show here that CyclinD-Cdk4/6...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.03.068
更新日期：2020-04-14 00:00:00
abstract：:Activation of postsynaptic metabotropic glutamate receptors (mGluRs) modulates neuronal excitability and synaptic plasticity, while deregulation of mGluR signaling has been implicated in neurodevelopmental disorders. Overstimulation of mGluRs is restricted by the rapid endocytosis of receptors after activation. Howeve...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.08.102
更新日期：2019-10-08 00:00:00
abstract：:The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for Duchenne muscular dystrophy. Here, we investigate a molecular basis for this variability. In muscle from Becker patients sharing the same exon 45-47 in-frame deletio...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.07.066
更新日期：2015-09-08 00:00:00
abstract：:Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we observe repression of host glycolysis in Mtb-infected macrophages, which is dependent on sustained u...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.015
更新日期：2020-01-07 00:00:00
abstract：:The conserved NAD+-dependent deacylase SIRT1 plays pivotal, sometimes contrasting, roles in diverse physiological and pathophysiological conditions. In this study, we uncover a tissue-restricted isoform of SIRT1 (SIRT1-ΔE2) that lacks exon 2 (E2). Candidate-based screening of SIRT1 substrates demonstrated that the dom...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.03.012
更新日期：2017-03-28 00:00:00
abstract：:The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.053
更新日期：2017-08-15 00:00:00
abstract：:Nutrient transporters can be rapidly removed from the cell surface via substrate-stimulated endocytosis as a way to control nutrient influx, but the molecular underpinnings are not well understood. In this work, we focus on zinc-dependent endocytosis of human ZIP4 (hZIP4), a zinc transporter that is essential for diet...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107582
更新日期：2020-04-28 00:00:00
abstract：:Riboswitches are mRNA elements regulating gene expression in response to direct binding of a metabolite. While these RNAs are increasingly well understood with respect to interactions between receptor domains and their cognate effector molecules, little is known about the specific mechanistic relationship between meta...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.03.087
更新日期：2016-05-03 00:00:00
abstract：:Indoleamine 2,3-dioxygenase (IDO) has been described as a major mechanism of immunosuppression in tumors, though the mechanisms of this are poorly understood. Here, we find that expression of IDO by tumor cells results in aggressive tumor growth and resistance to T-cell-targeting immunotherapies. We demonstrate that I...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.077
更新日期：2015-10-13 00:00:00
abstract：:Communication between organelles plays key roles in cell biology. In particular, physical and functional coupling of the endoplasmic reticulum (ER) and mitochondria is crucial for regulation of various physiological and pathophysiological processes. Here, we demonstrate that Presenilin 2 (PS2), mutations in which unde...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.05.013
更新日期：2016-06-07 00:00:00
abstract：:In spinal muscular atrophy, a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein, sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss. Whether central synaptic dysfunction and MN hyperexcitability are cell-autonomous events or t...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.087
更新日期：2016-08-02 00:00:00
abstract：:S1PR1 signaling has been shown to restrain the number and function of regulatory T (Treg) cells in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that S1PR1 signaling in T cells drives Treg accumulation in tumors, limits...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.02.016
更新日期：2014-03-27 00:00:00
abstract：:Mutation hotspots and showers occur across phylogeny and profoundly influence genome evolution, yet the mechanisms that produce hotspots remain obscure. We report that DNA double-strand breaks (DSBs) provoke mutation hotspots via stress-induced mutation in Escherichia coli. With tet reporters placed 2 kb to 2 Mb (half...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.08.033
更新日期：2012-10-25 00:00:00
abstract：:Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress the duration of Taxol-indu...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.03.038
更新日期：2017-04-04 00:00:00
abstract：:Soluble envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit neutralizing responses against HIV-1 strains closely related to the immunizing trimer. However, to date such stabilization has succeeded with only a limited number of HIV-1 strains. To address this issue, here we develop ADROITri...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108432
更新日期：2020-11-24 00:00:00
