Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents.

abstract：:S1PR1 signaling has been shown to restrain the number and function of regulatory T (Treg) cells in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that S1PR1 signaling in T cells drives Treg accumulation in tumors, limits...

journal_title：Cell reports

authors： Priceman SJ,Shen S,Wang L,Deng J,Yue C,Kujawski M,Yu H

更新日期：2014-03-27 00:00:00

abstract：:PARP1 plays a critical role in regulating many biological processes linked to cellular stress responses. Although DNA strand breaks are potent stimuli of PARP1 enzymatic activity, the context-dependent mechanism regulating PARP1 activation and signaling is poorly understood. We performed global characterization of the...

journal_title：Cell reports

authors： Zhen Y,Zhang Y,Yu Y

更新日期：2017-11-21 00:00:00

abstract：:Lipoprotein cholesterol is delivered to the limiting membrane of late endosomes/lysosomes (LELs) by Niemann-Pick C1 (NPC1). However, the mechanism of cholesterol transport from LELs to the endoplasmic reticulum (ER) is poorly characterized. We report that oxysterol-binding protein-related protein 1L (ORP1L) is necessa...

journal_title：Cell reports

authors： Zhao K,Ridgway ND

更新日期：2017-05-30 00:00:00

abstract：:Cytotoxic CD8(+) T lymphocytes play a critical role in the host response to infection by viruses. The ability to secrete cytotoxic chemicals and cytokines is considered pivotal for eliminating virus. Of equal importance is how effector CD8(+) T cells home to virus-infected tissues. L-selectin has not been considered i...

journal_title：Cell reports

authors： Mohammed RN,Watson HA,Vigar M,Ohme J,Thomson A,Humphreys IR,Ager A

更新日期：2016-02-02 00:00:00

abstract：:Dysfunction of microglia, the tissue macrophages of the brain, has been associated with the etiology of several neuropsychiatric disorders. Consistently, microglia have been shown to regulate neurogenesis and synaptic maturation at perinatal and postnatal stages. However, microglia invade the brain during mid-embryoge...

journal_title：Cell reports

authors： Squarzoni P,Oller G,Hoeffel G,Pont-Lezica L,Rostaing P,Low D,Bessis A,Ginhoux F,Garel S

更新日期：2014-09-11 00:00:00

abstract：:Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell biological processes that lead to mineral nucleation remains elusive. Here, we r...

journal_title：Cell reports

authors： Müller KH,Hayward R,Rajan R,Whitehead M,Cobb AM,Ahmad S,Sun M,Goldberga I,Li R,Bashtanova U,Puszkarska AM,Reid DG,Brooks RA,Skepper JN,Bordoloi J,Chow WY,Oschkinat H,Groombridge A,Scherman OA,Harrison JA,Verhulst

更新日期：2019-06-11 00:00:00

abstract：:Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM04) that targets a uniquely exposed epitope within the RBS; cross-neutralizes E...

journal_title：Cell reports

authors： Howell KA,Qiu X,Brannan JM,Bryan C,Davidson E,Holtsberg FW,Wec AZ,Shulenin S,Biggins JE,Douglas R,Enterlein SG,Turner HL,Pallesen J,Murin CD,He S,Kroeker A,Vu H,Herbert AS,Fusco ML,Nyakatura EK,Lai JR,Keck ZY,

更新日期：2016-05-17 00:00:00

abstract：:Alzheimer's disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J20) mutations to investigate transcriptional changes associated with the progress...

journal_title：Cell reports

authors： Castanho I,Murray TK,Hannon E,Jeffries A,Walker E,Laing E,Baulf H,Harvey J,Bradshaw L,Randall A,Moore K,O'Neill P,Lunnon K,Collier DA,Ahmed Z,O'Neill MJ,Mill J

更新日期：2020-02-11 00:00:00

abstract：:Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how p...

journal_title：Cell reports

authors： Chatterjee A,Ghosh J,Ramdas B,Mali RS,Martin H,Kobayashi M,Vemula S,Canela VH,Waskow ER,Visconte V,Tiu RV,Smith CC,Shah N,Bunting KD,Boswell HS,Liu Y,Chan RJ,Kapur R

更新日期：2014-11-20 00:00:00

abstract：:Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α...

journal_title：Cell reports

authors： Traub S,Meier DT,Schulze F,Dror E,Nordmann TM,Goetz N,Koch N,Dalmas E,Stawiski M,Makshana V,Thorel F,Herrera PL,Böni-Schnetzler M,Donath MY

更新日期：2017-03-28 00:00:00

abstract：:Chromatin posttranslational modifications (PTMs), including monoubiquitylation of histone H2B on lysine 120 (H2Bub1), play a major role in regulating genome functions. To elucidate the molecular mechanisms of H2Bub1 activity, a chromatin template uniformly containing H2Bub1 was used as an affinity matrix to identify p...

journal_title：Cell reports

authors： Shema-Yaacoby E,Nikolov M,Haj-Yahya M,Siman P,Allemand E,Yamaguchi Y,Muchardt C,Urlaub H,Brik A,Oren M,Fischle W

更新日期：2013-08-15 00:00:00

abstract：:The endoplasmic reticulum (ER) unfolded protein response (UPR(er)) pathway plays an important role in helping pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPR(er) gene expression appears in rodent and human type 2 diabetic (T2D) islets, the underlyin...

journal_title：Cell reports

authors： Rabhi N,Denechaud PD,Gromada X,Hannou SA,Zhang H,Rashid T,Salas E,Durand E,Sand O,Bonnefond A,Yengo L,Chavey C,Bonner C,Kerr-Conte J,Abderrahmani A,Auwerx J,Fajas L,Froguel P,Annicotte JS

更新日期：2016-05-03 00:00:00

abstract：:Synapses are fundamental to the normal function of the nervous system. Glia play a pivotal role in regulating synaptic formation. However, how presynaptic neurons assemble synaptic structure in response to the glial signals remains largely unexplored. To address this question, we use cima-1 mutant C. elegans as an in ...

journal_title：Cell reports

authors： Dong X,Jin S,Shao Z

更新日期：2020-02-25 00:00:00

abstract：:Mutations in WNK kinases cause the human hypertensive disease pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK kinases are not well understood. Mutations in kelch-like 3 (KLHL3) and Cullin3 were also recently identified as causing PHAII. Therefore, new insights into the mechanisms of h...

journal_title：Cell reports

authors： Wakabayashi M,Mori T,Isobe K,Sohara E,Susa K,Araki Y,Chiga M,Kikuchi E,Nomura N,Mori Y,Matsuo H,Murata T,Nomura S,Asano T,Kawaguchi H,Nonoyama S,Rai T,Sasaki S,Uchida S

更新日期：2013-03-28 00:00:00

abstract：:Building an integrated view of cellular responses to environmental cues remains a fundamental challenge due to the complexity of intracellular networks in mammalian cells. Here, we introduce an integrative biochemical and genetic framework to dissect signal transduction events using multiple data types and, in particu...

journal_title：Cell reports

authors： Mertins P,Przybylski D,Yosef N,Qiao J,Clauser K,Raychowdhury R,Eisenhaure TM,Maritzen T,Haucke V,Satoh T,Akira S,Carr SA,Regev A,Hacohen N,Chevrier N

更新日期：2017-06-27 00:00:00

abstract：:Ectopic lipid deposition (ELD) is defined by excess fat storage in locations not classically associated with adipose tissue (AT) storage. ELD is positively correlated with insulin resistance and increased risk of metabolic disorders. ELD appears as lipid droplets or adipocytes, whose cell origin is unknown. We previou...

journal_title：Cell reports

authors： Girousse A,Gil-Ortega M,Bourlier V,Bergeaud C,Sastourné-Arrey Q,Moro C,Barreau C,Guissard C,Vion J,Arnaud E,Pradère JP,Juin N,Casteilla L,Sengenès C

更新日期：2019-04-09 00:00:00

abstract：:A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent antigenic stimulation. Here, we use in vivo deuterium labeling and ex vivo analys...

journal_title：Cell reports

authors： Ahmed R,Miners KL,Lahoz-Beneytez J,Jones RE,Roger L,Baboonian C,Zhang Y,Wang ECY,Hellerstein MK,McCune JM,Baird DM,Price DA,Macallan DC,Asquith B,Ladell K

更新日期：2020-12-15 00:00:00

abstract：:The hallmarks of age-related immune senescence are chronic inflammation, aberrant expansion of effector memory, and loss of naive T lymphocytes due in part to systemic activation of innate immune sensor NLRP3 inflammasome in myeloid lineage cells. The endogenous mechanisms that regulate inflammasome activation during ...

journal_title：Cell reports

authors： Spadaro O,Goldberg EL,Camell CD,Youm YH,Kopchick JJ,Nguyen KY,Bartke A,Sun LY,Dixit VD

更新日期：2016-02-23 00:00:00

abstract：:The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current experiments in rats investigate whether GDF15 induces an aversive visceral malaise-based state that mediates its acute anorectic effect and, through aversion cond...

journal_title：Cell reports

authors： Borner T,Wald HS,Ghidewon MY,Zhang B,Wu Z,De Jonghe BC,Breen D,Grill HJ

更新日期：2020-04-21 00:00:00

abstract：:The multiple functions of lysosomes are critically dependent on their ability to undergo bidirectional movement along microtubules between the center and the periphery of the cell. Centrifugal and centripetal movement of lysosomes is mediated by kinesin and dynein motors, respectively. We recently described a multi-su...

journal_title：Cell reports

authors： Guardia CM,Farías GG,Jia R,Pu J,Bonifacino JS

更新日期：2016-11-15 00:00:00

abstract：:The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was contradicted by the identification of capped transcripts missing portions of their 5' ends and a cytoplasmic complex that can restore the cap on uncapped mRNAs. In this study, we used accumulation of uncapped transcripts in cells inhibited ...

journal_title：Cell reports

authors： Mukherjee C,Patil DP,Kennedy BA,Bakthavachalu B,Bundschuh R,Schoenberg DR

更新日期：2012-09-27 00:00:00

abstract：:In Drosophila larvae, the class IV dendritic arborization (da) neurons are polymodal nociceptors. Here, we show that ppk26 (CG8546) plays an important role in mechanical nociception in class IV da neurons. Our immunohistochemical and functional results demonstrate that ppk26 is specifically expressed in class IV da ne...

journal_title：Cell reports

authors： Guo Y,Wang Y,Wang Q,Wang Z

更新日期：2014-11-20 00:00:00

abstract：:Oligodendrogenesis occurs during early postnatal development, coincident with neurogenesis and synaptogenesis, raising the possibility that microglia-dependent pruning mechanisms that modulate neurons regulate myelin sheath formation. Here we show a population of ameboid microglia migrating from the ventricular zone i...

journal_title：Cell reports

authors： Nemes-Baran AD,White DR,DeSilva TM

更新日期：2020-08-18 00:00:00

abstract：:Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) and other kinases, whereas long-term depression (LTD) requires phosphatases. Here, we found that LTD also requires CaMKII and its phospho-T286-induced "autonomous" (Ca(2+)-...

journal_title：Cell reports

authors： Coultrap SJ,Freund RK,O'Leary H,Sanderson JL,Roche KW,Dell'Acqua ML,Bayer KU

更新日期：2014-02-13 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease. CAV1 and CAV2 organize membrane lipid rafts (MLRs) important for cell signaling and neuronal survival, and overexpression of CAV1 ameliorates ALS phenotypes in vivo. Genome-wide association studies localize a large proportion of ALS risk va...

journal_title：Cell reports

authors： Cooper-Knock J,Zhang S,Kenna KP,Moll T,Franklin JP,Allen S,Nezhad HG,Iacoangeli A,Yacovzada NY,Eitan C,Hornstein E,Elhaik E,Celadova P,Bose D,Farhan S,Fishilevich S,Lancet D,Morrison KE,Shaw CE,Al-Chalabi A,Projec

更新日期：2020-12-01 00:00:00

abstract：:Long-lasting forms of synaptic plasticity such as synaptic scaling are critically dependent on transcription. Activity-dependent transcriptional dynamics in neurons, however, remain incompletely characterized because most previous efforts relied on measurement of steady-state mRNAs. Here, we use nascent RNA sequencing...

journal_title：Cell reports

authors： Garay PM,Chen A,Tsukahara T,Rodríguez Díaz JC,Kohen R,Althaus JC,Wallner MA,Giger RJ,Jones KS,Sutton MA,Iwase S

更新日期：2020-08-11 00:00:00

abstract：:Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency compar...

journal_title：Cell reports

authors： Li X,Liu S,Huang H,Liu N,Zhao C,Liao S,Yang C,Liu Y,Zhao C,Li S,Lu X,Liu C,Guan L,Zhao K,Shi X,Song W,Zhou P,Dong X,Guo H,Wen G,Zhang C,Jiang L,Ma N,Li B,Wang S,Tan H,Wang X,Dou QP,Liu J

更新日期：2013-01-31 00:00:00

abstract：:The Drosophila pharyngeal taste organs are poorly characterized despite their location at important sites for monitoring food quality. Functional analysis of pharyngeal neurons has been hindered by the paucity of molecular tools to manipulate them, as well as their relative inaccessibility for neurophysiological inves...

journal_title：Cell reports

authors： Chen YD,Dahanukar A

更新日期：2017-12-05 00:00:00

abstract：:Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene ...

journal_title：Cell reports

authors： Hatakeyama H,Wu SY,Lyons YA,Pradeep S,Wang W,Huang Q,Court KA,Liu T,Nie S,Rodriguez-Aguayo C,Shen F,Huang Y,Hisamatsu T,Mitamura T,Jennings N,Shim J,Dorniak PL,Mangala LS,Petrillo M,Petyuk VA,Schepmoes AA,Shukla

更新日期：2016-11-01 00:00:00

abstract：:Fc receptor for IgM (FcμR)-deficient mice display dysregulated function of neutrophils, dendritic cells, and B cells. The relevance of FcμR to human T cells is still unknown. We show that FcμR is mostly stored inside the cell and that surface expression is tightly regulated. Decreased surface expression on T cells fro...

journal_title：Cell reports

authors： Meryk A,Pangrazzi L,Hagen M,Hatzmann F,Jenewein B,Jakic B,Hermann-Kleiter N,Baier G,Jylhävä J,Hurme M,Trieb K,Grubeck-Loebenstein B

更新日期：2019-03-05 00:00:00