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Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers.

Abstract：

:Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

journal_name

Cell Rep

journal_title

Cell reports

authors

Hatakeyama H,Wu SY,Lyons YA,Pradeep S,Wang W,Huang Q,Court KA,Liu T,Nie S,Rodriguez-Aguayo C,Shen F,Huang Y,Hisamatsu T,Mitamura T,Jennings N,Shim J,Dorniak PL,Mangala LS,Petrillo M,Petyuk VA,Schepmoes AA,Shukla

doi

10.1016/j.celrep.2016.10.020

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1621-1631

issue

6

issn

2211-1247

pii

S2211-1247(16)31406-1

journal_volume

17

pub_type

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