Abstract：
:Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among the most common gastrointestinal disorders. Inflamed tissues frequently experience conditions of insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia and consequent stabilization of the hypoxia-inducible factor 1α (HIF1α) transcription factor occur in murine and human pancreatitis. Mice lacking pancreas-specific HIF1α expression display markedly impaired pancreatic regeneration following cerulein-induced pancreatitis, which is associated with excessive intrapancreatic B cell accumulation. Notably, B cell depletion in mice with established pancreatitis significantly enhances tissue regeneration. Our study reveals a crosstalk between pancreatic HIF1α expression and B cell trafficking that regulates tissue regeneration, and identifies plausible molecular targets for treating pancreatitis patients.
journal_name
Cell Repjournal_title
Cell reportsauthors
Lee KE,Spata M,Maduka R,Vonderheide RH,Simon MCdoi
10.1016/j.celrep.2018.05.071subject
Has Abstractpub_date
2018-06-19 00:00:00pages
3457-3464issue
12issn
2211-1247pii
S2211-1247(18)30835-0journal_volume
23pub_type
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