Abstract:
:The dynamic interactions between synaptic excitation and inhibition (E/I) shape membrane potential fluctuations and determine patterns of neuronal outputs; however, the spatiotemporal organization of these interactions within a single cell is poorly understood. Here, we investigated the relationship between local synaptic excitation and global inhibition in hippocampal pyramidal neurons using functional dendrite imaging in combination with whole-cell recordings of inhibitory postsynaptic currents. We found that the sums of spine inputs over dendritic trees were counterbalanced by a proportional amount of somatic inhibitory inputs. This online E/I correlation was maintained in dendritic segments that were longer than 50 μm. However, at the single spine level, only 22% of the active spines were activated with inhibitory inputs. This inhibition-coupled activity occurred mainly in the spines with large heads. These results shed light on a microscopic E/I-balancing mechanism that operates at selected synapses and that may increase the accuracy of neural information.
journal_name
Cell Repjournal_title
Cell reportsauthors
Takahashi N,Kobayashi C,Ishikawa T,Ikegaya Ydoi
10.1016/j.celrep.2016.01.024subject
Has Abstractpub_date
2016-02-16 00:00:00pages
1348-1354issue
6issn
2211-1247pii
S2211-1247(16)00045-0journal_volume
14pub_type
杂志文章相关文献
Cell Reports文献大全abstract::The first cell fate choice of the preimplantation embryo generates the extraembryonic trophoblast and embryonic epiblast lineages. Embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) can be utilized to investigate molecular mechanisms of this first cell fate decision. It has been established that ESCs can be...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.04.040
更新日期:2017-05-09 00:00:00
abstract::The recent availability of somatic haploid cell lines has provided a unique tool for genetic studies in mammals. However, the percentage of haploid cells rapidly decreases in these cell lines, which we recently showed is due to their overgrowth by diploid cells present in the cultures. Based on this property, we have ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.06.060
更新日期:2019-07-16 00:00:00
abstract::Remyelination is a multistep regenerative process that results in the reformation of myelin sheaths around demyelinated axons and is a critical therapeutic target. Here we show that immediate access to a running wheel following toxin-induced demyelination in mice enhances oligodendrogenesis, the rate of remyelination,...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.08.060
更新日期:2018-09-18 00:00:00
abstract::The root stem cell niche, which is composed of four mitotically inactive quiescent center (QC) cells and the surrounding actively divided stem cells in Arabidopsis, is critical for growth and root development. Here, we demonstrate that the Arabidopsis prohibitin protein PHB3 is required for the maintenance of root ste...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.12.105
更新日期:2018-01-30 00:00:00
abstract::Current treatment regimens for pancreatic ductal adenocarcinoma (PDAC) yield poor 5-year survival, emphasizing the critical need to identify druggable targets essential for PDAC maintenance. We developed an unbiased and in vivo target discovery approach to identify molecular vulnerabilities in low-passage and patient-...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.05.063
更新日期:2016-06-28 00:00:00
abstract::APOBEC family cytidine deaminases have recently been implicated as powerful mutators of cancer genomes. How APOBECs, which are ssDNA-specific enzymes, gain access to chromosomal DNA is unclear. To ascertain the chromosomal ssDNA substrates of the APOBECs, we expressed APOBEC3A and APOBEC3B, the two most probable APOBE...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.01.021
更新日期:2016-02-16 00:00:00
abstract::Mutations of WD40-repeat protein 62 (WDR62) have been identified recently to cause human MCPH (autosomal-recessive primary microcephaly), a neurodevelopmental disorder characterized by decreased brain size. However, the underlying mechanism is unclear. Here, we investigate the function of WDR62 in brain development an...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.12.016
更新日期:2014-01-16 00:00:00
abstract::The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for Duchenne muscular dystrophy. Here, we investigate a molecular basis for this variability. In muscle from Becker patients sharing the same exon 45-47 in-frame deletio...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.07.066
更新日期:2015-09-08 00:00:00
abstract::Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD(+)-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the development of f...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.10.007
更新日期:2013-11-14 00:00:00
abstract::Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex. ...
journal_title:Cell reports
pub_type: 评论,杂志文章
doi:10.1016/j.celrep.2015.10.007
更新日期:2015-10-27 00:00:00
abstract::The traditional view of macrolide antibiotics as plugs inside the ribosomal nascent peptide exit tunnel (NPET) has lately been challenged in favor of a more complex, heterogeneous mechanism, where drug-peptide interactions determine the fate of a translating ribosome. To investigate these highly dynamic processes, we ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.04.034
更新日期:2014-06-12 00:00:00
abstract::Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of glutamine-deprived cells. However, pancreatic cancers are often poorly va...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.09.056
更新日期:2019-10-29 00:00:00
abstract::Human cells contain five canonical, replication-dependent somatic histone H1 subtypes (H1.1, H1.2, H1.3, H1.4, and H1.5). Although they are key chromatin components, the genomic distribution of the H1 subtypes is still unknown, and their role in chromatin processes has thus far remained elusive. Here, we map the genom...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.05.003
更新日期:2013-06-27 00:00:00
abstract::Chromothripsis represents a novel phenomenon in the structural variation landscape of cancer genomes. Here, we analyze the genomes of ten patients with congenital disease who were preselected to carry complex chromosomal rearrangements with more than two breakpoints. The rearrangements displayed unanticipated complexi...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2012.05.009
更新日期:2012-06-28 00:00:00
abstract::Measurements of flow velocities at the level of individual arterial vessels and sinusoidal capillaries are crucial for understanding the dynamics of hematopoietic stem and progenitor cell homing in the bone marrow vasculature. We have developed two complementary intravital two-photon imaging approaches to determine bl...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.01.042
更新日期:2017-02-14 00:00:00
abstract::The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or active regulators of the process. We show...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.02.051
更新日期:2019-03-12 00:00:00
abstract::Innate immunity is central to the pathophysiology of neurodegenerative disorders, but it remains unclear why immunity is altered in the disease state and whether changes in immunity are a cause or a consequence of neuronal dysfunction. Here, we identify a molecular pathway that links innate immunity to age-dependent l...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.12.025
更新日期:2019-01-02 00:00:00
abstract::Huntington's disease (HD) is a monogenic neurodegenerative disorder representing an ideal candidate for gene silencing with oligonucleotide therapeutics (i.e., antisense oligonucleotides [ASOs] and small interfering RNAs [siRNAs]). Using an ultra-sensitive branched fluorescence in situ hybridization (FISH) method, we ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.07.106
更新日期:2018-09-04 00:00:00
abstract::Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal TRM cells remains undefined. Here, we investigate transcriptional and functional heterogeneity of human TRM cells through study of donor-derived ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.108661
更新日期:2021-01-19 00:00:00
abstract::How mutations in glial fibrillary acidic protein (GFAP) cause Alexander disease (AxD) remains elusive. We generated iPSCs from two AxD patients and corrected the GFAP mutations to examine the effects of mutant GFAP on human astrocytes. AxD astrocytes displayed GFAP aggregates, recapitulating the pathological hallmark ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.09.083
更新日期:2018-10-23 00:00:00
abstract::How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.04.078
更新日期:2018-05-22 00:00:00
abstract::Chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nAChRs), and such upregulation is critical for the development of nicotine dependence in humans and animal models. However, how nicotine upregulates nAChRs is not well understood. Here, we identify a key role for microRNA in regulating nicotin...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.10.043
更新日期:2017-11-07 00:00:00
abstract::Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular origins, and this may bias sub...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.01.075
更新日期:2018-03-06 00:00:00
abstract::ATP citrate lyase (ACL) plays a key role in regulating mitochondrial function, as well as glucose and lipid metabolism in skeletal muscle. We report here that ACL silencing impairs myoblast and satellite cell (SC) differentiation, and it is accompanied by a decrease in fast myosin heavy chain isoforms and MYOD. Conver...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.11.038
更新日期:2017-12-12 00:00:00
abstract::In this issue of Cell Reports, Almendro et al. report one of the first comprehensive studies on the intratumor heterogeneity of cell phenotypes and genotypes before and after chemotherapy in breast cancer. These data challenge the concept of genetic population bottlenecks and suggest that cellular phenotypes play an i...
journal_title:Cell reports
pub_type: 评论,杂志文章
doi:10.1016/j.celrep.2014.01.035
更新日期:2014-02-13 00:00:00
abstract::The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based appro...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.03.085
更新日期:2019-04-23 00:00:00
abstract::Genome editing has now been reported in many systems using TALEN and CRISPR-Cas9 nucleases. Precise mutations can be introduced during homology-directed repair with donor DNA carrying the wanted sequence edit, but efficiency is usually lower than for gene knockout and optimal strategies have not been extensively inves...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.02.018
更新日期:2016-03-08 00:00:00
abstract::Redox-mediated posttranslational modifications represent a molecular switch that controls major mechanisms of cell function. Nitric oxide (NO) can mediate redox reactions via S-nitrosylation, representing transfer of an NO group to a critical protein thiol. NO is known to modulate neurogenesis and neuronal survival in...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.06.005
更新日期:2014-07-10 00:00:00
abstract::Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe an...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.02.050
更新日期:2018-03-06 00:00:00
abstract::Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) and other kinases, whereas long-term depression (LTD) requires phosphatases. Here, we found that LTD also requires CaMKII and its phospho-T286-induced "autonomous" (Ca(2+)-...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.01.005
更新日期:2014-02-13 00:00:00