Flow Dynamics and HSPC Homing in Bone Marrow Microvessels.

abstract：:Cyclin-dependent kinases (CDKs) contribute to vital cellular processes including cell cycle regulation. Loss of CDKs is associated with impaired insulin secretion and β cell survival; however, the function of CDK8 in β cells remains elusive. Here, we report that genetic ablation of Cdk8 improves glucose tolerance by i...

journal_title：Cell reports

authors： Xue J,Scotti E,Stoffel M

更新日期：2019-09-10 00:00:00

abstract：:The dynamic interactions between synaptic excitation and inhibition (E/I) shape membrane potential fluctuations and determine patterns of neuronal outputs; however, the spatiotemporal organization of these interactions within a single cell is poorly understood. Here, we investigated the relationship between local syna...

journal_title：Cell reports

authors： Takahashi N,Kobayashi C,Ishikawa T,Ikegaya Y

更新日期：2016-02-16 00:00:00

abstract：:Recycling of neurotransmitters is essential for sustained neuronal signaling, yet recycling pathways for various transmitters, including histamine, remain poorly understood. In the first visual ganglion (lamina) of Drosophila, photoreceptor-released histamine is taken up into perisynaptic glia, converted to carcinine,...

journal_title：Cell reports

authors： Chaturvedi R,Luan Z,Guo P,Li HS

更新日期：2016-03-08 00:00:00

abstract：:ADP-ribosylation (ADPr) is a reversible posttranslational modification involved in a range of cellular processes. Here, we report system-wide identification of serine ADPr in human cells upon oxidative stress. High-resolution mass spectrometry and unrestricted data processing confirm that serine residues are the major...

journal_title：Cell reports

authors： Larsen SC,Hendriks IA,Lyon D,Jensen LJ,Nielsen ML

更新日期：2018-08-28 00:00:00

abstract：:Amphotericin, miconazole, and ciclopirox are antifungal agents from three different drug classes that can effectively kill planktonic yeast, yet their complete fungicidal mechanisms are not fully understood. Here, we employ a systems biology approach to identify a common oxidative-damage cellular death pathway trigger...

journal_title：Cell reports

authors： Belenky P,Camacho D,Collins JJ

更新日期：2013-02-21 00:00:00

abstract：:It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state levels of only a minority of transcripts. Here, we use high-resolution Capture Hi-C to interrogate the dynamics of chromosomal contacts of all annota...

journal_title：Cell reports

authors： Thiecke MJ,Wutz G,Muhar M,Tang W,Bevan S,Malysheva V,Stocsits R,Neumann T,Zuber J,Fraser P,Schoenfelder S,Peters JM,Spivakov M

更新日期：2020-07-21 00:00:00

abstract：:Antiangiogenic therapy is commonly used in the clinic, but its beneficial effects are short-lived, leading to tumor relapse within months. Here, we found that the efficacy of angiogenic inhibitors targeting the VEGF/VEGFR pathway was dependent on induction of the angiostatic and immune-stimulatory chemokine CXCL14 in ...

journal_title：Cell reports

authors： Rivera LB,Meyronet D,Hervieu V,Frederick MJ,Bergsland E,Bergers G

更新日期：2015-04-28 00:00:00

abstract：:Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) an...

journal_title：Cell reports

authors： Brägelmann J,Dammert MA,Dietlein F,Heuckmann JM,Choidas A,Böhm S,Richters A,Basu D,Tischler V,Lorenz C,Habenberger P,Fang Z,Ortiz-Cuaran S,Leenders F,Eickhoff J,Koch U,Getlik M,Termathe M,Sallouh M,Greff Z,Varga Z

更新日期：2017-09-19 00:00:00

abstract：:How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, an essential member of the MLL chromatin modifying complex, that reg...

journal_title：Cell reports

authors： Li Q,Mao F,Zhou B,Huang Y,Zou Z,denDekker AD,Xu J,Hou S,Liu J,Dou Y,Rao RC

更新日期：2020-01-14 00:00:00

abstract：:The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined that the ablation of Esrp1 and Esrp2 impairs e...

journal_title：Cell reports

authors： Lee S,Cieply B,Yang Y,Peart N,Glaser C,Chan P,Carstens RP

更新日期：2018-11-27 00:00:00

abstract：:The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier, whereas their remodeling is required for angiogenesis in health and disease. Here, we position the ERAD-associated ubiquitin l...

journal_title：Cell reports

authors： Tan JME,van der Stoel MM,van den Berg M,van Loon NM,Moeton M,Scholl E,van der Wel NN,Kovačević I,Hordijk PL,Loregger A,Huveneers S,Zelcer N

更新日期：2020-08-04 00:00:00

abstract：:Virus infection is sensed by pattern recognition receptors (PRRs) detecting virus nucleic acids and initiating an innate immune response. DNA-dependent protein kinase (DNA-PK) is a PRR that binds cytosolic DNA and is antagonized by vaccinia virus (VACV) protein C16. Here, VACV protein C4 is also shown to antagonize DN...

journal_title：Cell reports

authors： Scutts SR,Ember SW,Ren H,Ye C,Lovejoy CA,Mazzon M,Veyer DL,Sumner RP,Smith GL

更新日期：2018-11-13 00:00:00

abstract：:SUMOylation has been implicated in cellular stress adaptation, but its role in regulating liver kinase B1 (LKB1), a major upstream kinase of the energy sensor AMP-activated protein kinase (AMPK), is unknown. Here, we show that energy stress triggers an increase in SUMO1 modification of LKB1, despite a global reduction...

journal_title：Cell reports

authors： Ritho J,Arold ST,Yeh ET

更新日期：2015-08-04 00:00:00

abstract：:Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. Here, we perform a combined whole-genome, coding and non-coding RNA and CpG methylation study following nerve injury. We show that genes involved in t...

journal_title：Cell reports

authors： Arthur-Farraj PJ,Morgan CC,Adamowicz M,Gomez-Sanchez JA,Fazal SV,Beucher A,Razzaghi B,Mirsky R,Jessen KR,Aitman TJ

更新日期：2017-09-12 00:00:00

abstract：:AMPK exerts prolongevity effects in diverse species; however, the tissue-specific mechanisms involved are poorly understood. Here, we show that upregulation of AMPK in the adult Drosophila nervous system induces autophagy both in the brain and also in the intestinal epithelium. Induction of autophagy is linked to impr...

journal_title：Cell reports

authors： Ulgherait M,Rana A,Rera M,Graniel J,Walker DW

更新日期：2014-09-25 00:00:00

abstract：:Dentate gyrus (DG) development requires specification of granule cell (GC) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG. We identify the Plexin family members Plxna2 and Plxna4 as important regulators of DG development. Distribution of immature GCs...

journal_title：Cell reports

authors： Zhao XF,Kohen R,Parent R,Duan Y,Fisher GL,Korn MJ,Ji L,Wan G,Jin J,Püschel AW,Dolan DF,Parent JM,Corfas G,Murphy GG,Giger RJ

更新日期：2018-01-09 00:00:00

abstract：:Glucose-stimulated insulin secretion from islet β cells is mediated by KATP channels. However, the role of non-KATP K+ channels in insulin secretion is largely unknown. Here, we show that a non-KATP K+ channel, KCNH6, plays a key role in insulin secretion and glucose hemostasis in humans and mice. KCNH6 p.P235L hetero...

journal_title：Cell reports

authors： Yang JK,Lu J,Yuan SS,Asan,Cao X,Qiu HY,Shi TT,Yang FY,Li Q,Liu CP,Wu Q,Wang YH,Huang HX,Kayoumu A,Feng JP,Xie RR,Zhu XR,Liu C,Yang GR,Zhang MR,Xie CL,Chen C,Zhang B,Liu G,Zhang XQ,Xu A

更新日期：2018-12-26 00:00:00

abstract：:Neurons face the challenge of maintaining cellular homeostasis through lysosomal degradation. While enzymatically active degradative lysosomes are enriched in the soma, their axonal trafficking and positioning and impact on axonal physiology remain elusive. Here, we characterized axon-targeted delivery of degradative ...

journal_title：Cell reports

authors： Farfel-Becker T,Roney JC,Cheng XT,Li S,Cuddy SR,Sheng ZH

更新日期：2019-07-02 00:00:00

abstract：:Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. However, recent work also shows that key molecular aspects of human END regulation differ even from rodents. Differentiation of human embryonic stem cells (ESCs) to END offers a tractable system to study the mole...

journal_title：Cell reports

authors： Genga RMJ,Kernfeld EM,Parsi KM,Parsons TJ,Ziller MJ,Maehr R

更新日期：2019-04-16 00:00:00

abstract：:The 40,000 neurons of the medulla, the largest visual processing center of the Drosophila brain, derive from a sheet of neuroepithelial cells. During larval development, a wave of differentiation sweeps across the neuroepithelium, converting neuroepithelial cells into neuroblasts that sequentially express transcriptio...

journal_title：Cell reports

authors： Caygill EE,Brand AH

更新日期：2017-08-08 00:00:00

abstract：:Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene deficiency leads to azoospermia b...

journal_title：Cell reports

authors： Ueda J,Harada A,Urahama T,Machida S,Maehara K,Hada M,Makino Y,Nogami J,Horikoshi N,Osakabe A,Taguchi H,Tanaka H,Tachiwana H,Yao T,Yamada M,Iwamoto T,Isotani A,Ikawa M,Tachibana T,Okada Y,Kimura H,Ohkawa Y,Kuru

更新日期：2017-01-17 00:00:00

abstract：:Telomerase biogenesis is a complex process where several steps remain poorly understood. Single-strand-selective uracil-DNA glycosylase (SMUG1) associates with the DKC1-containing H/ACA ribonucleoprotein complex, which is essential for telomerase biogenesis. Herein, we show that SMUG1 interacts with the telomeric RNA ...

journal_title：Cell reports

authors： Kroustallaki P,Lirussi L,Carracedo S,You P,Esbensen QY,Götz A,Jobert L,Alsøe L,Sætrom P,Gagos S,Nilsen H

更新日期：2019-08-13 00:00:00

abstract：:Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here,...

journal_title：Cell reports

authors： Ruivo MTG,Vera IM,Sales-Dias J,Meireles P,Gural N,Bhatia SN,Mota MM,Mancio-Silva L

更新日期：2016-09-06 00:00:00

abstract：:Huntington's disease (HD) is a monogenic neurodegenerative disorder representing an ideal candidate for gene silencing with oligonucleotide therapeutics (i.e., antisense oligonucleotides [ASOs] and small interfering RNAs [siRNAs]). Using an ultra-sensitive branched fluorescence in situ hybridization (FISH) method, we ...

journal_title：Cell reports

authors： Didiot MC,Ferguson CM,Ly S,Coles AH,Smith AO,Bicknell AA,Hall LM,Sapp E,Echeverria D,Pai AA,DiFiglia M,Moore MJ,Hayward LJ,Aronin N,Khvorova A

更新日期：2018-09-04 00:00:00

abstract：:Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers, regulates the self-renewal ability and pluripotency of ESCs. BRD4 inhibition resu...

journal_title：Cell reports

authors： Di Micco R,Fontanals-Cirera B,Low V,Ntziachristos P,Yuen SK,Lovell CD,Dolgalev I,Yonekubo Y,Zhang G,Rusinova E,Gerona-Navarro G,Cañamero M,Ohlmeyer M,Aifantis I,Zhou MM,Tsirigos A,Hernando E

更新日期：2014-10-09 00:00:00

abstract：:In mammals, a cell's decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here, we show that, in contrast, de...

journal_title：Cell reports

authors： Ehmer U,Zmoos AF,Auerbach RK,Vaka D,Butte AJ,Kay MA,Sage J

更新日期：2014-07-24 00:00:00

abstract：:Metazoan genomes are partitioned into modular chromosomal domains containing active or repressive chromatin. In flies, Polycomb group (PcG) response elements (PREs) recruit PHO and other DNA-binding factors and act as nucleation sites for the formation of Polycomb repressive domains. The sequence specificity of PREs i...

journal_title：Cell reports

authors： Schuettengruber B,Oded Elkayam N,Sexton T,Entrevan M,Stern S,Thomas A,Yaffe E,Parrinello H,Tanay A,Cavalli G

更新日期：2014-10-09 00:00:00

abstract：:Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia (AML), as these polyme...

journal_title：Cell reports

authors： Zhao Y,Liu Q,Acharya P,Stengel KR,Sheng Q,Zhou X,Kwak H,Fischer MA,Bradner JE,Strickland SA,Mohan SR,Savona MR,Venters BJ,Zhou MM,Lis JT,Hiebert SW

更新日期：2016-08-16 00:00:00

abstract：:The growth of B cell receptor (BCR) microclusters upon antigen stimulation drives B cell activation. Here, we show that PI3K-mediated PIP3 production is required for the growth of BCR microclusters. This growth is likely inhibited by PTEN and dependent on its plasma membrane binding and lipid phosphatase activities. M...

journal_title：Cell reports

authors： Wang J,Xu L,Shaheen S,Liu S,Zheng W,Sun X,Li Z,Liu W

更新日期：2017-11-28 00:00:00

abstract：:One of the most notable characteristics of synaptic transmission is the wide variation in synaptic strength in response to identical stimulation. In hippocampal neurons, approximately one-third of axonal mitochondria are highly motile, and some dynamically pass through presynaptic boutons. This raises a fundamental qu...

journal_title：Cell reports

authors： Sun T,Qiao H,Pan PY,Chen Y,Sheng ZH

更新日期：2013-08-15 00:00:00