Tumor evolution in response to chemotherapy: phenotype versus genotype.

Abstract:

:In this issue of Cell Reports, Almendro et al. report one of the first comprehensive studies on the intratumor heterogeneity of cell phenotypes and genotypes before and after chemotherapy in breast cancer. These data challenge the concept of genetic population bottlenecks and suggest that cellular phenotypes play an important role in developing resistance to therapy.

journal_name

Cell Rep

journal_title

Cell reports

authors

Navin NE

doi

10.1016/j.celrep.2014.01.035

subject

Has Abstract

pub_date

2014-02-13 00:00:00

pages

417-9

issue

3

issn

2211-1247

pii

S2211-1247(14)00069-2

journal_volume

6

pub_type

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