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The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity.

Abstract：

:Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.

journal_name

Cell Rep

journal_title

Cell reports

authors

Christoffersen C,Federspiel CK,Borup A,Christensen PM,Madsen AN,Heine M,Nielsen CH,Kjaer A,Holst B,Heeren J,Nielsen LB

doi

10.1016/j.celrep.2017.12.029

subject

Has Abstract

pub_date

2018-01-02 00:00:00

pages

175-188

issue

1

issn

2211-1247

pii

S2211-1247(17)31838-7

journal_volume

22

pub_type

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