Abstract：
:The cerebral cortex is organized in vertical columns that contain neurons with similar functions. The cellular micro-architecture of such columns is an essential determinant of brain dynamics and cortical information processing. However, a detailed understanding of columns is incomplete, even in the best studied cortical regions, and mostly restricted to the upper cortical layers. Here, we developed a two-photon Ca2+-imaging-based method for the serial functional mapping of all pyramidal layers of the mouse primary auditory cortex at single-neuron resolution in individual animals. We demonstrate that the best frequency-responsive neurons are organized in all-layers-crossing narrow columns, with fuzzy boundaries and a bandwidth of about one octave. This micro-architecture is, in many ways, different from what has been reported before, indicating the region and stimulus specificity of functional cortical columns in vivo.
journal_name
Cell Repjournal_title
Cell reportsauthors
Tischbirek CH,Noda T,Tohmi M,Birkner A,Nelken I,Konnerth Adoi
10.1016/j.celrep.2019.04.007subject
Has Abstractpub_date
2019-04-30 00:00:00pages
1319-1326.e5issue
5issn
2211-1247pii
S2211-1247(19)30462-0journal_volume
27pub_type
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