Identification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stability.

abstract：:Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate pathogen-induced signals to drive or suppress transcriptional programs speci...

journal_title：Cell reports

authors： Piovesan D,Tempany J,Di Pietro A,Baas I,Yiannis C,O'Donnell K,Chen Y,Peperzak V,Belz GT,Mackay CR,Smyth GK,Groom JR,Tarlinton DM,Good-Jacobson KL

更新日期：2017-04-18 00:00:00

abstract：:MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it challenging to delineate miRNA-mediated effects. Here, we describe an approach to characterizing miRNA-regulatory networks b...

journal_title：Cell reports

authors： Gosline SJ,Gurtan AM,JnBaptiste CK,Bosson A,Milani P,Dalin S,Matthews BJ,Yap YS,Sharp PA,Fraenkel E

更新日期：2016-01-12 00:00:00

abstract：:Transcription factors often activate and repress different target genes in the same cell. How activation and repression are encoded by different arrangements of transcription factor binding sites in cis-regulatory elements is poorly understood. We investigated how sites for the transcription factor CRX encode both act...

journal_title：Cell reports

authors： White MA,Kwasnieski JC,Myers CA,Shen SQ,Corbo JC,Cohen BA

更新日期：2016-10-25 00:00:00

abstract：:The RNA binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system, and disruption of Rbfox1 has been implicated in autism. However, comprehensive identification of functional Rbfox targets has been challenging. Here, we perform HITS-CLIP for all three Rbfox family members in order to globally map...

journal_title：Cell reports

authors： Weyn-Vanhentenryck SM,Mele A,Yan Q,Sun S,Farny N,Zhang Z,Xue C,Herre M,Silver PA,Zhang MQ,Krainer AR,Darnell RB,Zhang C

更新日期：2014-03-27 00:00:00

abstract：:Ribosomes and a subset of cellular mRNAs are trafficked into axons of developing neurons. The axonal localization of translational machinery allows new proteins to be rapidly and locally synthesized during axonal growth and pathfinding. However, in mature neurons, axonal ribosomes are significantly reduced or even abs...

journal_title：Cell reports

authors： Costa RO,Martins H,Martins LF,Cwetsch AW,Mele M,Pedro JR,Tomé D,Jeon NL,Cancedda L,Jaffrey SR,Almeida RD

更新日期：2019-07-23 00:00:00

abstract：:Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs) occurs across a broad set of systems and is reported to be upregulated in cancer, where it promotes aggressive behavior. However, regulatory control of exosome secretion is poorly understood. Using cancer cells, we identified specialized...

journal_title：Cell reports

authors： Hoshino D,Kirkbride KC,Costello K,Clark ES,Sinha S,Grega-Larson N,Tyska MJ,Weaver AM

更新日期：2013-12-12 00:00:00

abstract：:Cilia mediate Hedgehog (Hh) signaling in vertebrates and Hh deregulation results in several clinical manifestations, such as obesity, cognitive disabilities, developmental malformations, and various cancers. Drosophila cells are nonciliated during development, which has led to the assumption that cilia-mediated Hh sig...

journal_title：Cell reports

authors： Kuzhandaivel A,Schultz SW,Alkhori L,Alenius M

更新日期：2014-05-08 00:00:00

abstract：:As three-dimensional cell culture formats gain in popularity, there emerges a need for tools that produce vast amounts of data on individual cells within the spheroids or organoids. Here, we present a microfluidic platform that provides access to such data by parallelizing the manipulation of individual spheroids with...

journal_title：Cell reports

authors： Tomasi RF,Sart S,Champetier T,Baroud CN

更新日期：2020-05-26 00:00:00

abstract：:The development of an embryo requires precise spatiotemporal regulation of cellular processes. During Drosophila gastrulation, a precise temporal pattern of cell division is encoded through transcriptional regulation of cdc25(string) in 25 distinct mitotic domains. Using a genetic screen, we demonstrate that the same ...

journal_title：Cell reports

authors： Momen-Roknabadi A,Di Talia S,Wieschaus E

更新日期：2016-09-13 00:00:00

abstract：:Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA) and Joubert-syndrome and related disorders (JSRD). We examined cilia biogenesis and function in cells derived from CEP290-LCA and CEP290-JSRD patients. CEP290 protein was reduced in L...

journal_title：Cell reports

authors： Shimada H,Lu Q,Insinna-Kettenhofen C,Nagashima K,English MA,Semler EM,Mahgerefteh J,Cideciyan AV,Li T,Brooks BP,Gunay-Aygun M,Jacobson SG,Cogliati T,Westlake CJ,Swaroop A

更新日期：2017-07-11 00:00:00

abstract：:Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messe...

journal_title：Cell reports

authors： Sinturel F,Navickas A,Wery M,Descrimes M,Morillon A,Torchet C,Benard L

更新日期：2015-09-22 00:00:00

abstract：:Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instability in both mammals a...

journal_title：Cell reports

authors： Bianchi FT,Tocco C,Pallavicini G,Liu Y,Vernì F,Merigliano C,Bonaccorsi S,El-Assawy N,Priano L,Gai M,Berto GE,Chiotto AM,Sgrò F,Caramello A,Tasca L,Ala U,Neri F,Oliviero S,Mauro A,Geley S,Gatti M,Di Cunto F

更新日期：2017-02-14 00:00:00

abstract：:Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...

journal_title：Cell reports

authors： Moore AR,Ran L,Guan Y,Sher JJ,Hitchman TD,Zhang JQ,Hwang C,Walzak EG,Shoushtari AN,Monette S,Murali R,Wiesner T,Griewank KG,Chi P,Chen Y

更新日期：2018-02-27 00:00:00

abstract：:Polymorphisms that alter serotonin transporter SERT expression and functionality increase the risks for autism and psychiatric traits. Here, we investigate how SERT controls serotonin signaling in developing CNS in mice. SERT is transiently expressed in specific sets of glutamatergic neurons and uptakes extrasynaptic ...

journal_title：Cell reports

authors： Chen X,Ye R,Gargus JJ,Blakely RD,Dobrenis K,Sze JY

更新日期：2015-01-20 00:00:00

abstract：:Spinal cord longitudinal axons comprise some of the longest axons in our body. However, mechanisms that drive this extra long-distance axonal growth are largely unclear. We found that ascending axons of rapidly adapting (RA) mechanoreceptors closely abut a previously undescribed population of roof plate-derived radial...

journal_title：Cell reports

authors： Kridsada K,Niu J,Haldipur P,Wang Z,Ding L,Li JJ,Lindgren AG,Herrera E,Thomas GM,Chizhikov VV,Millen KJ,Luo W

更新日期：2018-06-05 00:00:00

abstract：:We report the emergence of an endogenous circadian clock that regulates organogenesis in mouse fetal kidney. We detect circadian rhythms both in vivo with transcriptional profiling and ex vivo by bioluminescence. High-resolution structural analysis of embryonic explants reveals that global or local clock disruption re...

journal_title：Cell reports

authors： Dan H,Ruan T,Sampogna RV

更新日期：2020-05-19 00:00:00

abstract：:Measurements of flow velocities at the level of individual arterial vessels and sinusoidal capillaries are crucial for understanding the dynamics of hematopoietic stem and progenitor cell homing in the bone marrow vasculature. We have developed two complementary intravital two-photon imaging approaches to determine bl...

journal_title：Cell reports

authors： Bixel MG,Kusumbe AP,Ramasamy SK,Sivaraj KK,Butz S,Vestweber D,Adams RH

更新日期：2017-02-14 00:00:00

abstract：:The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-translational modifications also influence PP5 phosphatase activity. Here, we show a...

journal_title：Cell reports

authors： Dushukyan N,Dunn DM,Sager RA,Woodford MR,Loiselle DR,Daneshvar M,Baker-Williams AJ,Chisholm JD,Truman AW,Vaughan CK,Haystead TA,Bratslavsky G,Bourboulia D,Mollapour M

更新日期：2017-11-14 00:00:00

abstract：:High-grade serous ovarian carcinoma (HGSOC) originates mainly from the fallopian tube (FT) epithelium and always carries early TP53 mutations. We previously reported that tumors initiate in the FT fimbria epithelium because of apoptotic failure and the expansion of cells with DNA double-strand breaks (DSB) caused by b...

journal_title：Cell reports

authors： Wu NY,Huang HS,Chao TH,Chou HM,Fang C,Qin CZ,Lin CY,Chu TY,Zhou HH

更新日期：2017-03-14 00:00:00

abstract：:Increased calpain activity is linked to neuroinflammation including a heritable retinal disease caused by hyper-activating mutations in the calcium-activated calpain-5 (CAPN5) protease. Although structures for classical calpains are known, the structure of CAPN5, a non-classical calpain, remains undetermined. Here we ...

journal_title：Cell reports

authors： Velez G,Sun YJ,Khan S,Yang J,Herrmann J,Chemudupati T,MacLaren RE,Gakhar L,Wakatsuki S,Bassuk AG,Mahajan VB

更新日期：2020-01-21 00:00:00

abstract：:Cognitive dysfunction and decreased mobility from aging and neurodegenerative conditions, such as Parkinson and Alzheimer diseases, are major biomedical challenges in need of more effective therapies. Increasing brain resilience may represent a new treatment strategy. Klotho, a longevity factor, enhances cognition whe...

journal_title：Cell reports

authors： Leon J,Moreno AJ,Garay BI,Chalkley RJ,Burlingame AL,Wang D,Dubal DB

更新日期：2017-08-08 00:00:00

abstract：:Natural killer (NK) cells possess potent cytotoxic mechanisms that need to be tightly controlled. Here, we explored the regulation and function of GPR56/ADGRG1, an adhesion G protein-coupled receptor implicated in developmental processes and expressed distinctively in mature NK cells. Expression of GPR56 was triggered...

journal_title：Cell reports

authors： Chang GW,Hsiao CC,Peng YM,Vieira Braga FA,Kragten NA,Remmerswaal EB,van de Garde MD,Straussberg R,König GM,Kostenis E,Knäuper V,Meyaard L,van Lier RA,van Gisbergen KP,Lin HH,Hamann J

更新日期：2016-05-24 00:00:00

abstract：:MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells follow...

journal_title：Cell reports

authors： Chen Z,Stelekati E,Kurachi M,Yu S,Cai Z,Manne S,Khan O,Yang X,Wherry EJ

更新日期：2017-09-12 00:00:00

abstract：:In Drosophila larvae, the class IV dendritic arborization (da) neurons are polymodal nociceptors. Here, we show that ppk26 (CG8546) plays an important role in mechanical nociception in class IV da neurons. Our immunohistochemical and functional results demonstrate that ppk26 is specifically expressed in class IV da ne...

journal_title：Cell reports

authors： Guo Y,Wang Y,Wang Q,Wang Z

更新日期：2014-11-20 00:00:00

abstract：:Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how p...

journal_title：Cell reports

authors： Chatterjee A,Ghosh J,Ramdas B,Mali RS,Martin H,Kobayashi M,Vemula S,Canela VH,Waskow ER,Visconte V,Tiu RV,Smith CC,Shah N,Bunting KD,Boswell HS,Liu Y,Chan RJ,Kapur R

更新日期：2014-11-20 00:00:00

abstract：:Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the ...

journal_title：Cell reports

authors： Wang Y,Xu X,Maglic D,Dill MT,Mojumdar K,Ng PK,Jeong KJ,Tsang YH,Moreno D,Bhavana VH,Peng X,Ge Z,Chen H,Li J,Chen Z,Zhang H,Han L,Du D,Creighton CJ,Mills GB,Cancer Genome Atlas Research Network.,Camargo F,Liang

更新日期：2018-10-30 00:00:00

abstract：:Macrophages exist predominantly in two distinct states, G0 and a G1-like state that is accompanied by phosphorylation of SAMHD1 at T592. Here, we demonstrate that Toll-like receptor 4 (TLR4) activation can potently induce G0 arrest and SAMHD1 antiretroviral activity by an interferon (IFN)-independent pathway. This pat...

journal_title：Cell reports

authors： Mlcochova P,Winstone H,Zuliani-Alvarez L,Gupta RK

更新日期：2020-03-24 00:00:00

abstract：:Ectopic lipid deposition (ELD) is defined by excess fat storage in locations not classically associated with adipose tissue (AT) storage. ELD is positively correlated with insulin resistance and increased risk of metabolic disorders. ELD appears as lipid droplets or adipocytes, whose cell origin is unknown. We previou...

journal_title：Cell reports

authors： Girousse A,Gil-Ortega M,Bourlier V,Bergeaud C,Sastourné-Arrey Q,Moro C,Barreau C,Guissard C,Vion J,Arnaud E,Pradère JP,Juin N,Casteilla L,Sengenès C

更新日期：2019-04-09 00:00:00

abstract：:The H3K4me3 demethylase Kdm5a regulates gene transcription and is implicated in carcinogenesis. However, the role of Kdm5a in innate immune response remains poorly understood. Here, we demonstrate that Kdm5a deficiency impairs activation of natural killer (NK) cells, with decreased IFN-γ production. Accordingly, Kdm5a...

journal_title：Cell reports

authors： Zhao D,Zhang Q,Liu Y,Li X,Zhao K,Ding Y,Li Z,Shen Q,Wang C,Li N,Cao X

更新日期：2016-04-12 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is necessary for in vivo activation of HIFs and organismal adaptation to hy...

journal_title：Cell reports

authors： Hamanaka RB,Weinberg SE,Reczek CR,Chandel NS

更新日期：2016-04-19 00:00:00