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A Simple Grammar Defines Activating and Repressing cis-Regulatory Elements in Photoreceptors.

Abstract：

:Transcription factors often activate and repress different target genes in the same cell. How activation and repression are encoded by different arrangements of transcription factor binding sites in cis-regulatory elements is poorly understood. We investigated how sites for the transcription factor CRX encode both activation and repression in photoreceptors by assaying thousands of genomic and synthetic cis-regulatory elements in wild-type and Crx-/- retinas. We found that sequences with high affinity for CRX repress transcription, whereas sequences with lower affinity activate. This rule is modified by a cooperative interaction between CRX sites and sites for the transcription factor NRL, which overrides the repressive effect of high affinity for CRX. Our results show how simple rearrangements of transcription factor binding sites encode qualitatively different responses to a single transcription factor and explain how CRX plays multiple cis-regulatory roles in the same cell.

journal_name

Cell Rep

journal_title

Cell reports

authors

White MA,Kwasnieski JC,Myers CA,Shen SQ,Corbo JC,Cohen BA

doi

10.1016/j.celrep.2016.09.066

subject

Has Abstract

pub_date

2016-10-25 00:00:00

pages

1247-1254

issue

5

issn

2211-1247

pii

S2211-1247(16)31322-5

journal_volume

17

pub_type

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