Abstract：
:The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that lithium extends lifespan in female and male Drosophila, when administered throughout adulthood or only later in life. The life-extending mechanism involves the inhibition of glycogen synthase kinase-3 (GSK-3) and activation of the transcription factor nuclear factor erythroid 2-related factor (NRF-2). Combining genetic loss of the NRF-2 repressor Kelch-like ECH-associated protein 1 (Keap1) with lithium treatment revealed that high levels of NRF-2 activation conferred stress resistance, while low levels additionally promoted longevity. The discovery of GSK-3 as a therapeutic target for aging will likely lead to more effective treatments that can modulate mammalian aging and further improve health in later life.
journal_name
Cell Repjournal_title
Cell reportsauthors
Castillo-Quan JI,Li L,Kinghorn KJ,Ivanov DK,Tain LS,Slack C,Kerr F,Nespital T,Thornton J,Hardy J,Bjedov I,Partridge Ldoi
10.1016/j.celrep.2016.03.041subject
Has Abstractpub_date
2016-04-19 00:00:00pages
638-650issue
3issn
2211-1247pii
S2211-1247(16)30297-2journal_volume
15pub_type
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