Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.

Abstract:

:Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains failed to cause disease in immunocompetent mice, each accumulated in the brain, spleen, eye, testis, and kidney when type I interferon signaling was blocked and unexpectedly caused infection, immune cell infiltration, and swelling in the ankle. In pregnant mice, SPOV replicated in the placenta and fetus but did not cause placental insufficiency or microcephaly. We identified human antibodies from ZIKV or DENV immune subjects that neutralized SPOV infection and protected against lethal challenge. Our experiments describe similarities and differences in clinical syndromes between SPOV and ZIKV and suggest that their serological relatedness has implications for antibody therapeutics and flavivirus vaccine development.

journal_name

Cell Rep

journal_title

Cell reports

authors

Salazar V,Jagger BW,Mongkolsapaya J,Burgomaster KE,Dejnirattisai W,Winkler ES,Fernandez E,Nelson CA,Fremont DH,Pierson TC,Crowe JE Jr,Screaton GR,Diamond MS

doi

10.1016/j.celrep.2019.01.052

subject

Has Abstract

pub_date

2019-02-05 00:00:00

pages

1585-1597.e4

issue

6

issn

2211-1247

pii

S2211-1247(19)30081-6

journal_volume

26

pub_type

杂志文章
  • Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature.

    abstract::Mural cells (pericytes and vascular smooth muscle cells) are essential for the regulation of vascular networks and maintenance of vascular integrity, but their origins are diverse in different tissues and not known in the organs that arise from the ectoderm, such as skin. Here, we show that tissue-localized myeloid pr...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.02.069

    authors: Yamazaki T,Nalbandian A,Uchida Y,Li W,Arnold TD,Kubota Y,Yamamoto S,Ema M,Mukouyama YS

    更新日期:2017-03-21 00:00:00

  • ABCE1 Controls Ribosome Recycling by an Asymmetric Dynamic Conformational Equilibrium.

    abstract::The twin-ATPase ABCE1 has a vital function in mRNA translation by recycling terminated or stalled ribosomes. As for other functionally distinct ATP-binding cassette (ABC) proteins, the mechanochemical coupling of ATP hydrolysis to conformational changes remains elusive. Here, we use an integrated biophysical approach ...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.06.052

    authors: Gouridis G,Hetzert B,Kiosze-Becker K,de Boer M,Heinemann H,Nürenberg-Goloub E,Cordes T,Tampé R

    更新日期:2019-07-16 00:00:00

  • Mechanotransmission and Mechanosensing of Human alpha-Actinin 1.

    abstract::α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton through crosslinking the actin filaments, as well as in focal adhesion maturation. However, the molecular mechanisms underlying its functio...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.11.040

    authors: Le S,Hu X,Yao M,Chen H,Yu M,Xu X,Nakazawa N,Margadant FM,Sheetz MP,Yan J

    更新日期:2017-12-05 00:00:00

  • Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.

    abstract::Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how p...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2014.10.039

    authors: Chatterjee A,Ghosh J,Ramdas B,Mali RS,Martin H,Kobayashi M,Vemula S,Canela VH,Waskow ER,Visconte V,Tiu RV,Smith CC,Shah N,Bunting KD,Boswell HS,Liu Y,Chan RJ,Kapur R

    更新日期:2014-11-20 00:00:00

  • Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.

    abstract::Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show that the endonuclease Regnase-1 is critical for the degradation ...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.05.009

    authors: Yoshinaga M,Nakatsuka Y,Vandenbon A,Ori D,Uehata T,Tsujimura T,Suzuki Y,Mino T,Takeuchi O

    更新日期:2017-05-23 00:00:00

  • HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification.

    abstract::The recent HIV-1 vaccine failures highlight the need to better understand virus-host interactions. One key question is why CD8(+) T cell responses to two HIV-Gag regions are uniquely associated with delayed disease progression only in patients expressing a few rare HLA class I variants when these regions encode epitop...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2014.03.031

    authors: Tenzer S,Crawford H,Pymm P,Gifford R,Sreenu VB,Weimershaus M,de Oliveira T,Burgevin A,Gerstoft J,Akkad N,Lunn D,Fugger L,Bell J,Schild H,van Endert P,Iversen AKN

    更新日期:2014-04-24 00:00:00

  • A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2.

    abstract::The MEF2 family of transcription factors restricts excitatory synapse number in an activity-dependent fashion during development, yet MEF2 has not been implicated in long-term synaptic depression (LTD), which is thought to initiate synapse elimination. Mutations in MEF2 pathways are implicated in autism spectrum disor...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.01.004

    authors: Andzelm MM,Vanness D,Greenberg ME,Linden DJ

    更新日期:2019-01-29 00:00:00

  • Symmetry Breaking in an Edgeless Epithelium by Fat2-Regulated Microtubule Polarity.

    abstract::Planar cell polarity (PCP) information is a critical determinant of organ morphogenesis. While PCP in bounded epithelial sheets is increasingly well understood, how PCP is organized in tubular and acinar tissues is not. Drosophila egg chambers (follicles) are an acinus-like "edgeless epithelium" and exhibit a continuo...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.04.014

    authors: Chen DY,Lipari KR,Dehghan Y,Streichan SJ,Bilder D

    更新日期:2016-05-10 00:00:00

  • Specificity and function of archaeal DNA replication initiator proteins.

    abstract::Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and Cdt1. We find that the three origins in the single chromosome of the...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2013.01.002

    authors: Samson RY,Xu Y,Gadelha C,Stone TA,Faqiri JN,Li D,Qin N,Pu F,Liang YX,She Q,Bell SD

    更新日期:2013-02-21 00:00:00

  • miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.

    abstract::Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide protection from future encounters, and their generation is the goal of many vaccin...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.07.064

    authors: Gagnon JD,Kageyama R,Shehata HM,Fassett MS,Mar DJ,Wigton EJ,Johansson K,Litterman AJ,Odorizzi P,Simeonov D,Laidlaw BJ,Panduro M,Patel S,Jeker LT,Feeney ME,McManus MT,Marson A,Matloubian M,Sanjabi S,Ansel KM

    更新日期:2019-08-20 00:00:00

  • Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

    abstract::The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) cells, a subset of suppressive Foxp3+ regulatory T cells located within ...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.12.076

    authors: Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA

    更新日期:2020-01-21 00:00:00

  • Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling.

    abstract::Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the lipidome of white adipose tissue (WAT) and brown adipose tissue (BAT) are unknown. Here, we utilize MS/MSALL shotgun lipidomics to determine the molecular signatur...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.01.038

    authors: May FJ,Baer LA,Lehnig AC,So K,Chen EY,Gao F,Narain NR,Gushchina L,Rose A,Doseff AI,Kiebish MA,Goodyear LJ,Stanford KI

    更新日期:2017-02-07 00:00:00

  • Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles.

    abstract::Presynaptic endosomes reportedly participate in synaptic vesicle (SV) recycling. However, it remains unclear whether they differentially regulate SV biogenesis and synaptic transmission in different types of synapses and how they are implicated in diseases. Using cryo-electron tomography and endocytic tracing, we unco...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.06.006

    authors: Li X,Qin L,Li Y,Yu H,Zhang Z,Tao C,Liu Y,Xue Y,Zhang X,Xu Z,Wang Y,Lou H,Tan Z,Saftig P,Chen Z,Xu T,Bi G,Duan S,Gao Z

    更新日期:2019-07-23 00:00:00

  • CD57+ Memory T Cells Proliferate In Vivo.

    abstract::A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent antigenic stimulation. Here, we use in vivo deuterium labeling and ex vivo analys...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.108501

    authors: Ahmed R,Miners KL,Lahoz-Beneytez J,Jones RE,Roger L,Baboonian C,Zhang Y,Wang ECY,Hellerstein MK,McCune JM,Baird DM,Price DA,Macallan DC,Asquith B,Ladell K

    更新日期:2020-12-15 00:00:00

  • Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils.

    abstract::Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional features of their differentiation stages from bone marrow-residing progenitors ...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2018.08.018

    authors: Grassi L,Pourfarzad F,Ullrich S,Merkel A,Were F,Carrillo-de-Santa-Pau E,Yi G,Hiemstra IH,Tool ATJ,Mul E,Perner J,Janssen-Megens E,Berentsen K,Kerstens H,Habibi E,Gut M,Yaspo ML,Linser M,Lowy E,Datta A,Clarke L,F

    更新日期:2018-09-04 00:00:00

  • Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis.

    abstract::Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R agonist conjugate with modif...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.107768

    authors: Borner T,Workinger JL,Tinsley IC,Fortin SM,Stein LM,Chepurny OG,Holz GG,Wierzba AJ,Gryko D,Nexø E,Shaulson ED,Bamezai A,Da Silva VAR,De Jonghe BC,Hayes MR,Doyle RP

    更新日期:2020-06-16 00:00:00

  • Accessibility to Peptidoglycan Is Important for the Recognition of Gram-Positive Bacteria in Drosophila.

    abstract::In Drosophila, it is thought that peptidoglycan recognition proteins (PGRPs) SA and LC structurally discriminate between bacterial peptidoglycans with lysine (Lys) or diaminopimelic (DAP) acid, respectively, thus inducing differential antimicrobial transcription response. Here, we find that accessibility to PG at the ...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.04.103

    authors: Vaz F,Kounatidis I,Covas G,Parton RM,Harkiolaki M,Davis I,Filipe SR,Ligoxygakis P

    更新日期:2019-05-21 00:00:00

  • Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection.

    abstract::Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type I IFN ligands and ...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.108345

    authors: Irving AT,Zhang Q,Kong PS,Luko K,Rozario P,Wen M,Zhu F,Zhou P,Ng JHJ,Sobota RM,Wang LF

    更新日期:2020-11-03 00:00:00

  • Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity.

    abstract::Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is sufficient to extend lifespan in the fruit fly. This effect can be recapi...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.01.017

    authors: Martínez Corrales G,Filer D,Wenz KC,Rogan A,Phillips G,Li M,Feseha Y,Broughton SJ,Alic N

    更新日期:2020-02-11 00:00:00

  • Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.

    abstract::Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of glutamine-deprived cells. However, pancreatic cancers are often poorly va...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.09.056

    authors: Bott AJ,Shen J,Tonelli C,Zhan L,Sivaram N,Jiang YP,Yu X,Bhatt V,Chiles E,Zhong H,Maimouni S,Dai W,Velasquez S,Pan JA,Muthalagu N,Morton J,Anthony TG,Feng H,Lamers WH,Murphy DJ,Guo JY,Jin J,Crawford HC,Zhang

    更新日期:2019-10-29 00:00:00

  • YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis.

    abstract::Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in regulating the actomyosin network by suppressing Rho GTPase in medaka fish. Here, we identify Rho GTPase activating protein 29 (ARHGAP29) as a transc...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.04.075

    authors: Qiao Y,Chen J,Lim YB,Finch-Edmondson ML,Seshachalam VP,Qin L,Jiang T,Low BC,Singh H,Lim CT,Sudol M

    更新日期:2017-05-23 00:00:00

  • Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.

    abstract::Obesity is associated with colon cancer pathogenesis, but the underlying mechanism is actively debated. Here, we confirm that diet-induced obesity promotes tumor growth in two murine colon cancer models and show that this effect is reversed by an orally administered controlled-release mitochondrial protonophore (CRMP)...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2018.06.008

    authors: Wang Y,Nasiri AR,Damsky WE,Perry CJ,Zhang XM,Rabin-Court A,Pollak MN,Shulman GI,Perry RJ

    更新日期:2018-07-03 00:00:00

  • Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex.

    abstract::In contrast to our extensive knowledge on covalent small ubiquitin-like modifier (SUMO) target proteins, we are limited in our understanding of non-covalent SUMO-binding proteins. We identify interactors of different SUMO isoforms-monomeric SUMO1, monomeric SUMO2, or linear trimeric SUMO2 chains-using a mass spectrome...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2021.108691

    authors: González-Prieto R,Eifler-Olivi K,Claessens LA,Willemstein E,Xiao Z,Talavera Ormeno CMP,Ovaa H,Ulrich HD,Vertegaal ACO

    更新日期:2021-01-26 00:00:00

  • Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer.

    abstract::CD4 and CD8 T cells play a pivotal role in controlling tumor growth. However, the interplay of both cell types and their role in tumor suppression still remain elusive. In this study, we investigated the regulation of CD4 and CD8 T cell responses to different classes of tumor-specific antigens in liver cancer mouse mo...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.10.086

    authors: Knocke S,Fleischmann-Mundt B,Saborowski M,Manns MP,Kühnel F,Wirth TC,Woller N

    更新日期:2016-11-22 00:00:00

  • In Vivo Single-Cell Genotyping of Mouse Cortical Neurons Transfected with CRISPR/Cas9.

    abstract::CRISPR/Cas-based technologies have revolutionized genetic approaches to addressing a wide range of neurobiological questions. The ability of CRISPR/Cas to introduce mutations into target genes allows us to perform in vivo loss-of-function experiments without generating genetically engineered mice. However, the lack of...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.06.038

    authors: Steinecke A,Kurabayashi N,Hayano Y,Ishino Y,Taniguchi H

    更新日期:2019-07-09 00:00:00

  • Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics.

    abstract::A better understanding of the impact of antibiotics on bacteria is required to increase the efficiency of antibiotic treatments and to slow the emergence of resistance. Using Escherichia coli, we examined how bacteria exposed to sublethal concentrations of ampicillin adjust gene expression patterns and metabolism to s...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.09.001

    authors: Mathieu A,Fleurier S,Frénoy A,Dairou J,Bredeche MF,Sanchez-Vizuete P,Song X,Matic I

    更新日期:2016-09-27 00:00:00

  • Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors.

    abstract::Medium spiny neurons (MSNs) of mice show opposing activities upon the initiation of a food-seeking lever press task. Ventromedial striatal (VMS)-MSNs are inhibited but ventrolateral striatal (VLS)-MSNs are activated; these activities mediate action selection and action initiation, respectively. To understand what inpu...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.107829

    authors: Yoshida K,Tsutsui-Kimura I,Kono A,Yamanaka A,Kobayashi K,Watanabe M,Mimura M,Tanaka KF

    更新日期:2020-06-30 00:00:00

  • Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening.

    abstract::The recent success of derivation of mammalian haploid embryonic stem cells (haESCs) has provided a powerful tool for large-scale functional analysis of the mammalian genome. However, haESCs rapidly become diploidized after differentiation, posing challenges for genetic analysis. Here, we show that the spontaneous dipl...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.07.081

    authors: He ZQ,Xia BL,Wang YK,Li J,Feng GH,Zhang LL,Li YH,Wan HF,Li TD,Xu K,Yuan XW,Li YF,Zhang XX,Zhang Y,Wang L,Li W,Zhou Q

    更新日期:2017-08-29 00:00:00

  • B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.

    abstract::Antibodies secreted within the intestinal tract provide protection from the invasion of microbes into the host tissues. Germinal center (GC) formation in lymph nodes and spleen strictly requires SLAM-associated protein (SAP)-mediated T cell functions; however, it is not known whether this mechanism plays a similar rol...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.01.032

    authors: Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z

    更新日期:2020-02-11 00:00:00

  • Subcellular Imbalances in Synaptic Activity.

    abstract::The dynamic interactions between synaptic excitation and inhibition (E/I) shape membrane potential fluctuations and determine patterns of neuronal outputs; however, the spatiotemporal organization of these interactions within a single cell is poorly understood. Here, we investigated the relationship between local syna...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.01.024

    authors: Takahashi N,Kobayashi C,Ishikawa T,Ikegaya Y

    更新日期:2016-02-16 00:00:00