Abstract：
:Exercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors to brain repair and brain health. Nonetheless, the molecular details underlying these effects remain poorly understood. Conditional ablation of the Snf2h gene impairs cerebellar development producing mice with poor motor function, progressive ataxia, and death between postnatal days 25-45. Here, we show that voluntary running induced an endogenous brain repair mechanism that resulted in a striking increase in hindbrain myelination and the long-term survival of Snf2h cKO mice. Further experiments identified the VGF growth factor as a major driver underlying this effect. VGF neuropeptides promote oligodendrogenesis in vitro, whereas Snf2h cKO mice treated with full-length VGF-encoding adenoviruses removed the requirement of exercise for survival. Together, these results suggest that VGF delivery could represent a therapeutic strategy for cerebellar ataxia and other pathologies of the CNS.
journal_name
Cell Repjournal_title
Cell reportsauthors
Alvarez-Saavedra M,De Repentigny Y,Yang D,O'Meara RW,Yan K,Hashem LE,Racacho L,Ioshikhes I,Bulman DE,Parks RJ,Kothary R,Picketts DJdoi
10.1016/j.celrep.2016.09.030subject
Has Abstractpub_date
2016-10-11 00:00:00pages
862-875issue
3issn
2211-1247pii
S2211-1247(16)31252-9journal_volume
17pub_type
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