Abstract：
:Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene deficiency leads to azoospermia because of the loss of haploid germ cells. When differentiating spermatogonia emerge in normal spermatogenesis, H3t appears and replaces the canonical H3 proteins. Structural and biochemical analyses reveal that H3t-containing nucleosomes are more flexible than the canonical nucleosomes. Thus, by incorporating H3t into the genome during spermatogonial differentiation, male germ cells are able to enter meiosis and beyond.
journal_name
Cell Repjournal_title
Cell reportsauthors
Ueda J,Harada A,Urahama T,Machida S,Maehara K,Hada M,Makino Y,Nogami J,Horikoshi N,Osakabe A,Taguchi H,Tanaka H,Tachiwana H,Yao T,Yamada M,Iwamoto T,Isotani A,Ikawa M,Tachibana T,Okada Y,Kimura H,Ohkawa Y,Kurudoi
10.1016/j.celrep.2016.12.065subject
Has Abstractpub_date
2017-01-17 00:00:00pages
593-600issue
3issn
2211-1247pii
S2211-1247(16)31772-7journal_volume
18pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized mechanism of transcription interference. Here, we propose a comprehensive model ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107612
更新日期：2020-05-05 00:00:00
abstract：:Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human (HeLa) cells, and ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.07.024
更新日期：2013-08-29 00:00:00
abstract：:Early lineage-specific master regulators are essential for the specification of cell types. However, once cells are committed to a specific fate, it is critical to restrict the activity of such factors to enable differentiation. To date, it remains unclear how these factors are silenced. Using the Drosophila mesoderm ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108577
更新日期：2021-01-05 00:00:00
abstract：:Schwann cells (SCs) myelinate peripheral neurons to promote the rapid conduction of action potentials, and the process of myelination is known to be regulated by signals from axons to SCs. Given that SC mitochondria are one of the potential regulators of myelination, we investigated whether SC mitochondria are regulat...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.039
更新日期：2015-09-29 00:00:00
abstract：:At presynaptic active zones, exocytosis of neurotransmitter vesicles (SVs) is driven by SNARE complexes that recruit Syb2 and SNAP25. However, it remains unknown which SNAREs promote the secretion of neuronal proteins, including those essential for circuit development and experience-dependent plasticity. Here we demon...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.04.032
更新日期：2015-05-19 00:00:00
abstract：:Some epigenetic modifications are inherited from one generation to the next, providing a potential mechanism for the inheritance of environmentally acquired traits. Transgenerational inheritance of RNAi phenotypes in Caenorhabditis elegans provides an excellent model to study this phenomenon, and although studies have...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.10.085
更新日期：2018-11-20 00:00:00
abstract：:The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more responsive than are binucleated cardiomyocytes to pro-proliferative stimuli. We...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.034
更新日期：2020-03-03 00:00:00
abstract：:The innate immune system senses cytosolic dsDNA and bacterial cyclic dinucleotides and initiates signaling via the adaptor STING to induce type 1 interferon (IFN) response. We demonstrate here that BTK-deficient cells have impaired IFN-β production and TBK1/IRF3 activation when stimulated with agonists or infected wit...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.01.039
更新日期：2015-02-24 00:00:00
abstract：:It is known that plant cells can contain multiple distinct vacuoles; however, the abundance of multivacuolar cells and the mechanisms underlying vacuolar differentiation and communication among different types of vacuoles remain unknown. PH1 and PH5 are tonoplast P-ATPases that form a heteromeric pump that hyper-acidi...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.05.076
更新日期：2017-06-20 00:00:00
abstract：:Plasmodium parasites infect the liver and replicate inside hepatocytes before they invade erythrocytes and trigger clinical malaria. Analysis of host signaling pathways affected by liver-stage infection could provide critical insights into host-pathogen interactions and reveal targets for intervention. Using protein l...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.02.010
更新日期：2013-03-28 00:00:00
abstract：:T and innate lymphoid cells (ILCs) share some aspects of their developmental programs. However, although Notch signaling is strictly required for T cell development, it is dispensable for fetal ILC development. Constitutive activation of Notch signaling, at the common lymphoid progenitor stage, drives T cell developme...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.01.015
更新日期：2016-02-16 00:00:00
abstract：:Animal nervous systems remodel following stress. Although global stress-dependent changes are well documented, contributions of individual neuron remodeling events to animal behavior modification are challenging to study. In response to environmental insults, C. elegans become stress-resistant dauers. Dauer entry indu...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108607
更新日期：2021-01-12 00:00:00
abstract：:Senescence is a cellular response preventing tumorigenesis. The Ras oncogene is frequently activated or mutated in human cancers, but Ras activation is insufficient to transform primary cells. In a search for cooperating oncogenes, we identify the lysine demethylase JMJD2A/KDM4A. We show that JMJD2A functions as a neg...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.09.033
更新日期：2012-11-29 00:00:00
abstract：:Quiescence is a fundamental property of adult stem cells. Recent evidence indicates that quiescence is not a default state but requires active signaling that prevents accidental or untimely activation of stem cells. The calcitonin receptor (CalcR) is critical for sustaining quiescence in muscle satellite (stem) cells ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.10.057
更新日期：2019-11-19 00:00:00
abstract：:Breast cancer stem cells (BCSCs) play a critical role in tumor recurrence and metastasis. Exposure of breast cancer cells to chemotherapy leads to an enrichment of BCSCs. Here, we find that chemotherapy induces the expression of glutathione S-transferase omega 1 (GSTO1), which is dependent on hypoxia-inducible factor ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.02.001
更新日期：2017-02-21 00:00:00
abstract：:The mammalian target of rapamycin complex 1 (mTORC1) integrates signals important for cell growth, and its dysregulation in neural stem cells (NSCs) is implicated in several neurological disorders associated with abnormal neurogenesis and brain size. However, the function of mTORC1 on NSC self-renewal and the downstre...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.09.017
更新日期：2013-10-31 00:00:00
abstract：:Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo. Analysis of resting microglia identified 29 genes that distinguish mic...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.06.018
更新日期：2013-07-25 00:00:00
abstract：:Sensory information is selectively or non-selectively enhanced and inhibited in the brain, but it remains unclear whether and how this occurs at the most peripheral level. Using in vivo calcium imaging of mouse olfactory bulb and olfactory epithelium in wild-type and mutant animals, we show that odors produce not only...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107814
更新日期：2020-06-30 00:00:00
abstract：:In the presynaptic terminal, the magnitude and location of Ca2+ entry through voltage-gated Ca2+ channels (VGCCs) regulate the efficacy of neurotransmitter release. However, how presynaptic active zone proteins control mammalian VGCC levels and organization is unclear. To address this, we deleted the CAST/ELKS protein...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.024
更新日期：2018-07-10 00:00:00
abstract：:People tend to fall asleep when gently rocked or vibrated. Experimental studies have shown that rocking promotes sleep in humans and mice. However, the mechanisms underlying the phenomenon are not well understood. A habituation model proposes that habituation, a form of non-associative learning, mediates sleep inducti...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108462
更新日期：2020-12-01 00:00:00
abstract：:Horizontal transmission of the microbiota between different individuals is widely used to normalize the microbiota in laboratory mice. However, little is known about the dynamics of microbial communities and the level of microbiota transmission after cohousing. We extensively analyzed the fecal microbiota in Jackson a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.05.042
更新日期：2019-06-11 00:00:00
abstract：:Nuclear factor κB (NF-κB) RelA is the potent transcriptional activator of inflammatory response genes. We stringently defined a list of direct RelA target genes by integrating physical (chromatin immunoprecipitation sequencing [ChIP-seq]) and functional (RNA sequencing [RNA-seq] in knockouts) datasets. We then dissect...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.01.108
更新日期：2020-02-25 00:00:00
abstract：:Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the oncogenic potential of these cells have been described. However, the universal applicability of these tumor-suppressive barriers remains contro...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.04.006
更新日期：2018-05-01 00:00:00
abstract：:The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the primary cilium. Additionally, Shh controls axon guidance through a non-canonical...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.11.015
更新日期：2019-12-10 00:00:00
abstract：:The Drosophila pharyngeal taste organs are poorly characterized despite their location at important sites for monitoring food quality. Functional analysis of pharyngeal neurons has been hindered by the paucity of molecular tools to manipulate them, as well as their relative inaccessibility for neurophysiological inves...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.11.041
更新日期：2017-12-05 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease. CAV1 and CAV2 organize membrane lipid rafts (MLRs) important for cell signaling and neuronal survival, and overexpression of CAV1 ameliorates ALS phenotypes in vivo. Genome-wide association studies localize a large proportion of ALS risk va...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108456
更新日期：2020-12-01 00:00:00
abstract：:Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate and are thus essential for glutamatergic neurotransmission. However, VGLUTs were originally discovered as members of a transporter subfamily specific for inorganic phosphate (Pi). It is still unclear how VGLUTs accommodate glutamate transp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.055
更新日期：2018-04-10 00:00:00
abstract：:Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. Here we show that TLR2 induces complement factors C3 and CFB, the common and rate-limiting fac...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.01.064
更新日期：2020-02-18 00:00:00
abstract：:Mutations in WNK kinases cause the human hypertensive disease pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK kinases are not well understood. Mutations in kelch-like 3 (KLHL3) and Cullin3 were also recently identified as causing PHAII. Therefore, new insights into the mechanisms of h...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.02.024
更新日期：2013-03-28 00:00:00
abstract：:The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM and 7-methyl guanosine diphosphate (7-MeGpp). We identify feature...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.08.091
更新日期：2016-09-20 00:00:00
