当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon response.

Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon response.

Abstract：

:The innate immune system senses cytosolic dsDNA and bacterial cyclic dinucleotides and initiates signaling via the adaptor STING to induce type 1 interferon (IFN) response. We demonstrate here that BTK-deficient cells have impaired IFN-β production and TBK1/IRF3 activation when stimulated with agonists or infected with pathogens that activate STING signaling. BTK interacts with STING and DDX41 helicase. The kinase and SH3/SH2 interaction domains of BTK bind, respectively, the DEAD-box domain of DDX41 and transmembrane region of STING. BTK phosphorylates DDX41, and its kinase activities are critical for STING-mediated IFN-β production. We show that Tyr364 and Tyr414 of DDX41 are critical for its recognition of AT-rich DNA and binding to STING, and tandem mass spectrometry identifies Tyr414 as the BTK phosphorylation site. Modeling studies further indicate that phospho-Tyr414 strengthens DDX41's interaction with STING. Hence, BTK plays a critical role in the activation of DDX41 helicase and STING signaling.

journal_name

Cell Rep

journal_title

Cell reports

authors

Lee KG,Kim SS,Kui L,Voon DC,Mauduit M,Bist P,Bi X,Pereira NA,Liu C,Sukumaran B,Rénia L,Ito Y,Lam KP

doi

10.1016/j.celrep.2015.01.039

subject

Has Abstract

pub_date

2015-02-24 00:00:00

pages

1055-65

issue

7

issn

2211-1247

pii

S2211-1247(15)00064-9

journal_volume

10

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Chaperoning HMGA2 protein protects stalled replication forks in stem and cancer cells.

    abstract：:Maintaining genome integrity requires the accurate and complete replication of chromosomal DNA. This is of the utmost importance for embryonic stem cells (ESCs), which differentiate into cells of all lineages, including germ cells. However, endogenous and exogenous factors frequently induce stalling of replication for...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.01.014

    authors： Yu H,Lim HH,Tjokro NO,Sathiyanathan P,Natarajan S,Chew TW,Klonisch T,Goodman SD,Surana U,Dröge P

    更新日期：2014-02-27 00:00:00

  • Interphase Microtubules Safeguard Mitotic Progression by Suppressing an Aurora B-Dependent Arrest Induced by DNA Replication Stress.

    abstract：:The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or active regulators of the process. We show...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.02.051

    authors： Laflamme G,Sim S,Leary A,Pascariu M,Vogel J,D'Amours D

    更新日期：2019-03-12 00:00:00

  • The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance.

    abstract：:The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the primary cilium. Additionally, Shh controls axon guidance through a non-canonical...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.015

    authors： Ferent J,Constable S,Gigante ED,Yam PT,Mariani LE,Legué E,Liem KF Jr,Caspary T,Charron F

    更新日期：2019-12-10 00:00:00

  • From Retina to Stem Cell and Back Again: Memories of a Chromatin Journey.

    abstract：:The use of retinal organoids requires efficient differentiation from induced pluripotent stem cells (iPSCs). In this issue of Cell Reports, Wang et al. (2018) examine how the chromatin landscape after iPSC programming predicts their ability to differentiate into retinal tissue. ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.078

    authors： Roberts JM,Vetter ML

    更新日期：2018-03-06 00:00:00

  • Folate Acts in E. coli to Accelerate C. elegans Aging Independently of Bacterial Biosynthesis.

    abstract：:Folates are cofactors for biosynthetic enzymes in all eukaryotic and prokaryotic cells. Animals cannot synthesize folate and must acquire it from their diet or microbiota. Previously, we showed that inhibiting E. coli folate synthesis increases C. elegans lifespan. Here, we show that restriction or supplementation of ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.01.051

    authors： Virk B,Jia J,Maynard CA,Raimundo A,Lefebvre J,Richards SA,Chetina N,Liang Y,Helliwell N,Cipinska M,Weinkove D

    更新日期：2016-02-23 00:00:00

  • Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.

    abstract：:Squamous cell carcinoma (SCC) of the lung is the second most common subtype of lung cancer. With limited treatment options, the 5-year survival rate of SCC is only 15%. Although genomic alterations in SCC have been characterized, identifying the alterations that drive SCC is critical for improving treatment strategies...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.05.036

    authors： Mukhopadhyay A,Berrett KC,Kc U,Clair PM,Pop SM,Carr SR,Witt BL,Oliver TG

    更新日期：2014-07-10 00:00:00

  • Increasing MuSK activity delays denervation and improves motor function in ALS mice.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating disease that progresses from detachment of motor nerve terminals to complete muscle paralysis and lethal respiratory failure within 5 years of diagnosis. Genetic studies have linked mutations in several genes to ALS, and mice bearing mutations in SOD1 recapitulate h...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.08.004

    authors： Pérez-García MJ,Burden SJ

    更新日期：2012-09-27 00:00:00

  • The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.

    abstract：:The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier, whereas their remodeling is required for angiogenesis in health and disease. Here, we position the ERAD-associated ubiquitin l...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107944

    authors： Tan JME,van der Stoel MM,van den Berg M,van Loon NM,Moeton M,Scholl E,van der Wel NN,Kovačević I,Hordijk PL,Loregger A,Huveneers S,Zelcer N

    更新日期：2020-08-04 00:00:00

  • AMPK modulates tissue and organismal aging in a non-cell-autonomous manner.

    abstract：:AMPK exerts prolongevity effects in diverse species; however, the tissue-specific mechanisms involved are poorly understood. Here, we show that upregulation of AMPK in the adult Drosophila nervous system induces autophagy both in the brain and also in the intestinal epithelium. Induction of autophagy is linked to impr...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.08.006

    authors： Ulgherait M,Rana A,Rera M,Graniel J,Walker DW

    更新日期：2014-09-25 00:00:00

  • The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.

    abstract：:DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental and cellular processes and ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.11.082

    authors： Veland N,Hardikar S,Zhong Y,Gayatri S,Dan J,Strahl BD,Rothbart SB,Bedford MT,Chen T

    更新日期：2017-12-19 00:00:00

  • DET1 and HY5 Control PIF4-Mediated Thermosensory Elongation Growth through Distinct Mechanisms.

    abstract：:Plant growth and development are defined by environmental cues. The transcription factor PHYTOCHROME INTERACTING FACTOR 4 (PIF4) is the central signaling hub that integrates environmental cues, including light and temperature, to regulate growth and development. The thermosensory mechanisms controlling the PIF4-mediat...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.046

    authors： Gangappa SN,Kumar SV

    更新日期：2017-01-10 00:00:00

  • Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling.

    abstract：:Effective approaches to neuropsychiatric disorders require detailed understanding of the cellular composition and circuitry of the complex mammalian brain. Here, we present a paradigm for deconstructing the diversity of neurons defined by a specific neurotransmitter using a microfluidic dynamic array to simultaneously...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.10.008

    authors： Poulin JF,Zou J,Drouin-Ouellet J,Kim KY,Cicchetti F,Awatramani RB

    更新日期：2014-11-06 00:00:00

  • An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.

    abstract：:There is an urgent need to identify new treatments for fungal infections. By combining sub-lethal concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, terbinafine, benomyl, and cyprodinil with ∼3,600 compounds in diverse fungal species, we generated a deep reservoir of chemical-chemical in...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.10.018

    authors： Robbins N,Spitzer M,Yu T,Cerone RP,Averette AK,Bahn YS,Heitman J,Sheppard DC,Tyers M,Wright GD

    更新日期：2015-11-17 00:00:00

  • A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress.

    abstract：:SUMOylation has been implicated in cellular stress adaptation, but its role in regulating liver kinase B1 (LKB1), a major upstream kinase of the energy sensor AMP-activated protein kinase (AMPK), is unknown. Here, we show that energy stress triggers an increase in SUMO1 modification of LKB1, despite a global reduction...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.07.002

    authors： Ritho J,Arold ST,Yeh ET

    更新日期：2015-08-04 00:00:00

  • Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.

    abstract：:Sleep regulation involves interdependent signaling among specialized neurons in distributed brain regions. Although acetylcholine promotes wakefulness and rapid eye movement (REM) sleep, it is unclear whether the cholinergic pathway is essential (i.e., absolutely required) for REM sleep because of redundancy from neur...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.082

    authors： Niwa Y,Kanda GN,Yamada RG,Shi S,Sunagawa GA,Ukai-Tadenuma M,Fujishima H,Matsumoto N,Masumoto KH,Nagano M,Kasukawa T,Galloway J,Perrin D,Shigeyoshi Y,Ukai H,Kiyonari H,Sumiyama K,Ueda HR

    更新日期：2018-08-28 00:00:00

  • Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis.

    abstract：:Pneumonias caused by influenza A virus (IAV) co- and secondary bacterial infections are characterized by their severity and high mortality rate. Previously, we have shown that bacterial pore-forming toxin (PFT)-mediated necroptosis is a key driver of acute lung injury during bacterial pneumonia. Here, we evaluate the ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108062

    authors： Gonzalez-Juarbe N,Riegler AN,Jureka AS,Gilley RP,Brand JD,Trombley JE,Scott NR,Platt MP,Dube PH,Petit CM,Harrod KS,Orihuela CJ

    更新日期：2020-08-25 00:00:00

  • A Chemogenetic Tool that Enables Functional Neural Circuit Analysis.

    abstract：:Chemogenetics enables manipulation of neuronal activity in experimental animals. While providing information about the transduced neuron expressing a ligand-activated molecule, chemogenetics does not provide understanding about the antecedent circuit that drives that neuron's activity. For current approaches, this is ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108139

    authors： Ngo HB,Melo MR,Layfield S,Connelly AA,Bassi JK,Xie L,Menuet C,McDougall SJ,Bathgate RAD,Allen AM

    更新日期：2020-09-15 00:00:00

  • Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death.

    abstract：:The stress-activated protein kinases c-Jun N-terminal kinase (JNK) and p38 are important players in cell-fate decisions in response to environmental stress signals. Crosstalk signaling between JNK and p38 is emerging as an important regulatory mechanism in inflammatory and stress responses. However, it is unknown how ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.08.020

    authors： Miura H,Kondo Y,Matsuda M,Aoki K

    更新日期：2018-09-04 00:00:00

  • mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression.

    abstract：:Effector, but not naïve, T cells are activated by toll-like receptor-2 (TLR2) stimulation, leading to cytokine production and proliferation. We found that the differential response is attributable to the lack of expression of the adaptor protein TIRAP in naive T cells. TIRAP expression is induced upon T-cell receptor ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107911

    authors： Imanishi T,Unno M,Kobayashi W,Yoneda N,Akira S,Saito T

    更新日期：2020-07-21 00:00:00

  • Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway.

    abstract：:The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the precise pathways relaying mechanoresponsive signals into intracellular sensors remain unclear. Here, we uncover a functi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.02.041

    authors： Chakraborty S,Njah K,Pobbati AV,Lim YB,Raju A,Lakshmanan M,Tergaonkar V,Lim CT,Hong W

    更新日期：2017-03-07 00:00:00

  • Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.

    abstract：:The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;Runx3 double-knockout (DKO) mice exhibited lethal phenotypes due to bo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.046

    authors： Wang CQ,Krishnan V,Tay LS,Chin DW,Koh CP,Chooi JY,Nah GS,Du L,Jacob B,Yamashita N,Lai SK,Tan TZ,Mori S,Tanuichi I,Tergaonkar V,Ito Y,Osato M

    更新日期：2014-08-07 00:00:00

  • Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection.

    abstract：:The enteroinvasive bacterium Shigella flexneri forces its uptake into non-phagocytic host cells through the translocation of T3SS effectors that subvert the actin cytoskeleton. Here, we report de novo actin polymerization after cellular entry around the bacterium-containing vacuole (BCV) leading to the formation of a ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107638

    authors： Kühn S,Bergqvist J,Gil M,Valenzuela C,Barrio L,Lebreton S,Zurzolo C,Enninga J

    更新日期：2020-05-12 00:00:00

  • Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.

    abstract：:We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6-8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression of mitochondr...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.093

    authors： Adam J,Ramracheya R,Chibalina MV,Ternette N,Hamilton A,Tarasov AI,Zhang Q,Rebelato E,Rorsman NJG,Martín-Del-Río R,Lewis A,Özkan G,Do HW,Spégel P,Saitoh K,Kato K,Igarashi K,Kessler BM,Pugh CW,Tamarit-Rodriguez J,Mu

    更新日期：2017-09-26 00:00:00

  • Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets.

    abstract：:Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal TRM cells remains undefined. Here, we investigate transcriptional and functional heterogeneity of human TRM cells through study of donor-derived ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108661

    authors： FitzPatrick MEB,Provine NM,Garner LC,Powell K,Amini A,Irwin SL,Ferry H,Ambrose T,Friend P,Vrakas G,Reddy S,Soilleux E,Klenerman P,Allan PJ

    更新日期：2021-01-19 00:00:00

  • Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.

    abstract：:Proprioception, the sense of limb and body position, is essential for generating proper movement. Unconscious proprioceptive information travels through cerebellar-projecting neurons in the spinal cord and medulla. The progenitor domain defined by the basic-helix-loop-helix (bHLH) transcription factor, ATOH1, has been...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.09.064

    authors： Yuengert R,Hori K,Kibodeaux EE,McClellan JX,Morales JE,Huang TP,Neul JL,Lai HC

    更新日期：2015-11-10 00:00:00

  • Structural Basis of the Diversity of Adrenergic Receptors.

    abstract：:Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, and understanding this diversity is key for designing selective or biased drugs for them. Here, we determine two crystal structures of the α2A adrenergic receptor (α2AAR) in complex with a partia...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.088

    authors： Qu L,Zhou Q,Xu Y,Guo Y,Chen X,Yao D,Han GW,Liu ZJ,Stevens RC,Zhong G,Wu D,Zhao S

    更新日期：2019-12-03 00:00:00

  • Discovery and Characterization of piRNAs in the Human Fetal Ovary.

    abstract：:Piwi-interacting RNAs (piRNAs), a class of 26- to 32-nt non-coding RNAs (ncRNAs), function in germline development, transposon silencing, and epigenetic regulation. We performed deep sequencing and annotation of untreated and periodate-treated small RNA cDNA libraries from human fetal and adult germline and reference ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.09.030

    authors： Williams Z,Morozov P,Mihailovic A,Lin C,Puvvula PK,Juranek S,Rosenwaks Z,Tuschl T

    更新日期：2015-10-27 00:00:00

  • Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.

    abstract：:Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requisite for the respons...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.066

    authors： Wei T,Najmi SM,Liu H,Peltonen K,Kucerova A,Schneider DA,Laiho M

    更新日期：2018-04-10 00:00:00

  • Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis.

    abstract：:The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations of EZH2 and their role in cancer pathogenesis. Here, we show that SET and MYND domain containing 2 (S...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.004

    authors： Zeng Y,Qiu R,Yang Y,Gao T,Zheng Y,Huang W,Gao J,Zhang K,Liu R,Wang S,Hou Y,Yu W,Leng S,Feng D,Liu W,Zhang X,Wang Y

    更新日期：2019-11-05 00:00:00

  • Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation.

    abstract：:Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.123

    authors： Takahashi Y,Sekine K,Kin T,Takebe T,Taniguchi H

    更新日期：2018-05-08 00:00:00