Abstract：
:Despite the comprehensive knowledge on odor coding, our understanding of the relationship between sensory input and behavioral output in Drosophila remains weak. Here, we measure the behavioral responses generated by larval and adult flies in response to 34 fruit odors and find that larval preference for fruit odors differs from that of adult flies. Next, we provide a functional analysis of the full repertoire of the peripheral olfactory system using the same comprehensive stimulus spectrum. We find that 90% and 53% of larval and adult olfactory receptors tested here, respectively, are involved in evaluating these fruit odors. Finally, we find that the total amount of olfactory neuronal activity correlates strongly positively with behavioral output in larvae and correlates weakly negatively in adult flies. Our results suggest that larval and adult flies have evolved different mechanisms for detection and computation of fruit odors, mechanisms likely mirroring the different lifestyles of both developmental stages.
journal_name
Cell Repjournal_title
Cell reportsauthors
Dweck HKM,Ebrahim SAM,Retzke T,Grabe V,Weißflog J,Svatoš A,Hansson BS,Knaden Mdoi
10.1016/j.celrep.2018.04.085subject
Has Abstractpub_date
2018-05-22 00:00:00pages
2524-2531issue
8issn
2211-1247pii
S2211-1247(18)30663-6journal_volume
23pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Synaptic efficacy plays crucial roles in neuronal circuit operation and synaptic plasticity. Presynaptic determinants of synaptic efficacy are neurotransmitter content in synaptic vesicles and the number of vesicles undergoing exocytosis at a time. Bursts of presynaptic firings depress synaptic efficacy, mainly due to...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.080
更新日期：2018-03-20 00:00:00
abstract：:Naproxen is a non-steroidal anti-inflammatory drug that has previously been shown to exert antiviral activity against influenza A virus by inhibiting nucleoprotein (NP) binding to RNA. Here, we show that naproxen is a potential broad, multi-mechanistic anti-influenza virus therapeutic, as it inhibits influenza B virus...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.053
更新日期：2019-05-07 00:00:00
abstract：:Antibodies secreted within the intestinal tract provide protection from the invasion of microbes into the host tissues. Germinal center (GC) formation in lymph nodes and spleen strictly requires SLAM-associated protein (SAP)-mediated T cell functions; however, it is not known whether this mechanism plays a similar rol...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.01.032
更新日期：2020-02-11 00:00:00
abstract：:MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells follow...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.08.060
更新日期：2017-09-12 00:00:00
abstract：:Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM04) that targets a uniquely exposed epitope within the RBS; cross-neutralizes E...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.04.026
更新日期：2016-05-17 00:00:00
abstract：:Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program of multisite phosphorylation that regulates the conversion of Gli proteins into transcriptional activators. In the absence of Hh ligands, Gli activity is restrained by the direct phospho...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.12.003
更新日期：2014-01-16 00:00:00
abstract：:Glioblastoma (GBM) is highly refractory to therapy and associated with poor clinical outcome. Here, we reveal a critical function of the promitotic and adhesion-mediating discoidin domain receptor 1 (DDR1) in modulating GBM therapy resistance. In GBM cultures and clinical samples, we show a DDR1 and GBM stem cell mark...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.02.096
更新日期：2019-03-26 00:00:00
abstract：:Haplo-insufficiency of telomerase genes in humans leads to telomere syndromes such as dyskeratosis congenital and idiopathic pulmonary fibrosis. Generation of pluripotent stem cells from telomerase haplo-insufficient donor cells would provide unique opportunities toward the realization of patient-specific stem cell th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.10.052
更新日期：2014-12-11 00:00:00
abstract：:Emerging evidence has shown that noncoding RNAs, particularly microRNAs (miRNAs), contribute to the pathogenesis of mood and anxiety disorders, although the molecular mechanisms are poorly understood. Here, we show that altered levels of miR-17-92 in adult hippocampal neural progenitors have a significant impact on ne...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.101
更新日期：2016-08-09 00:00:00
abstract：:Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functions. Here, we show ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2011.12.002
更新日期：2012-02-23 00:00:00
abstract：:The mechanisms by which p53 suppresses tumor growth remain ill defined. In this issue of Cell Reports, Timofeev et al. (2013) and Valente et al. (2013) reveal context-dependent contributions of p53-dependent apoptosis to its tumor-suppressive function. ...
journal_title：Cell reports
pub_type： 评论,杂志文章
doi：10.1016/j.celrep.2013.05.011
更新日期：2013-05-30 00:00:00
abstract：:Cell size control emerges from a regulated balance between the rates of cell growth and division. In bacteria, simple quantitative laws connect cellular growth rate to ribosome abundance. However, it remains poorly understood how translation regulates bacterial cell size and shape under growth perturbations. Here, we ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108183
更新日期：2020-09-22 00:00:00
abstract：:It has been proposed that sleep's contribution to memory consolidation is to reactivate prior encoded information. To elucidate the neural mechanisms carrying reactivation-related mnemonic information, we investigated whether content-specific memory signatures associated with memory reactivation during wakefulness reo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.09.037
更新日期：2018-10-09 00:00:00
abstract：:Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two opp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.09.002
更新日期：2013-10-17 00:00:00
abstract：:Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)-18 and driving an essential interferon (IFN)-γ response that primes casp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107967
更新日期：2020-07-28 00:00:00
abstract：:Squamous cell carcinoma (SCC) of the lung is the second most common subtype of lung cancer. With limited treatment options, the 5-year survival rate of SCC is only 15%. Although genomic alterations in SCC have been characterized, identifying the alterations that drive SCC is critical for improving treatment strategies...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.05.036
更新日期：2014-07-10 00:00:00
abstract：:DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental and cellular processes and ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.11.082
更新日期：2017-12-19 00:00:00
abstract：:The Hsp90 chaperone is essential in eukaryotes and activates a large array of client proteins. In contrast, its role is still elusive in bacteria, and only a few Hsp90 bacterial clients are known. Here, we found that Hsp90 is essential in the model bacterium Shewanella oneidensis under heat stress. A genetic screen fo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.03.082
更新日期：2017-04-25 00:00:00
abstract：:Altering the redox state of cysteine residues on protein surfaces is an important response to environmental challenges. Although aging and fasting alter many redox processes, the role of cysteine residues is uncertain. To address this, we used a redox proteomic technique, oxidative isotope-coded affinity tags (OxICAT)...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.05.033
更新日期：2015-06-30 00:00:00
abstract：:Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate pathogen-induced signals to drive or suppress transcriptional programs speci...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.03.060
更新日期：2017-04-18 00:00:00
abstract：:The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of glomerular podocytes. Combining functional measurements of oxygen consumption r...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.012
更新日期：2019-04-30 00:00:00
abstract：:The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to be accelerated aging due to hyperphosphatemia and soft tissue calcification. In contrast, the overexpression of αKlotho increases lifespan. Given the severe mouse phenotype, we generated zebrafish mutants for αklotho as well as i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.08.013
更新日期：2019-09-10 00:00:00
abstract：:DNA methylation provides a mechanism by which environmental factors can control insulin sensitivity in obesity. Here, we assessed DNA methylation in skeletal muscle from obese people before and after Roux-en-Y gastric bypass (RYGB). Obesity was associated with altered expression of a subset of genes enriched in metabo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.03.018
更新日期：2013-04-25 00:00:00
abstract：:Recent reports suggest that botulinum neurotoxin (BoNT) A, which is widely used clinically to inhibit neurotransmission, can spread within networks of neurons to have distal effects, but this remains controversial. Moreover, it is not known whether other members of this toxin family are transferred between neurons. He...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.104
更新日期：2016-08-16 00:00:00
abstract：:5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be elucidated. Here, we show that chronic restraint stress (CRS) induced depression-l...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.11.061
更新日期：2018-12-11 00:00:00
abstract：:Increased calpain activity is linked to neuroinflammation including a heritable retinal disease caused by hyper-activating mutations in the calcium-activated calpain-5 (CAPN5) protease. Although structures for classical calpains are known, the structure of CAPN5, a non-classical calpain, remains undetermined. Here we ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.077
更新日期：2020-01-21 00:00:00
abstract：:Indoleamine 2,3-dioxygenase (IDO) has been described as a major mechanism of immunosuppression in tumors, though the mechanisms of this are poorly understood. Here, we find that expression of IDO by tumor cells results in aggressive tumor growth and resistance to T-cell-targeting immunotherapies. We demonstrate that I...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.077
更新日期：2015-10-13 00:00:00
abstract：:Transport of RNAs to dendrites occurs in neuronal RNA granules, which allows local synthesis of specific proteins at active synapses on demand, thereby contributing to learning and memory. To gain insight into the machinery controlling dendritic mRNA localization and translation, we established a stringent protocol to...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.11.023
更新日期：2013-12-26 00:00:00
abstract：:Presenilin 1 (PS1) is the catalytic core of γ-secretase, which cleaves type 1 transmembrane proteins, including the amyloid precursor protein (APP). PS1 also has γ-secretase-independent functions, and dominant PS1 missense mutations are the most common cause of familial Alzheimer's disease (FAD). Whether PS1 FAD mutat...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.10.018
更新日期：2013-11-27 00:00:00
abstract：:The architecture of renal glomeruli is acquired through intricate and still poorly understood developmental steps. In our study we identify a crucial glomerular morphogenetic event in nephrogenesis that drives the remodeling/separation of the prospective vascular pole (the future entrance of the glomerular arterioles)...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108304
更新日期：2020-10-27 00:00:00
