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miR-17-92 Cluster Regulates Adult Hippocampal Neurogenesis, Anxiety, and Depression.

Abstract：

:Emerging evidence has shown that noncoding RNAs, particularly microRNAs (miRNAs), contribute to the pathogenesis of mood and anxiety disorders, although the molecular mechanisms are poorly understood. Here, we show that altered levels of miR-17-92 in adult hippocampal neural progenitors have a significant impact on neurogenesis and anxiety- and depression-related behaviors in mice. miR-17-92 deletion in adult neural progenitors decreases neurogenesis in the dentate gyrus, while its overexpression increases neurogenesis. miR-17-92 affects neurogenesis by regulating genes in the glucocorticoid pathway, especially serum- and glucocorticoid-inducible protein kinase-1 (Sgk1). miR-17-92 knockout mice show anxiety- and depression-like behaviors, whereas miR-17-92 overexpressing mice exhibit anxiolytic and antidepression-like behaviors. Furthermore, we show that miR-17-92 expression in the adult mouse hippocampus responds to chronic stress, and miR-17-92 rescues proliferation defects induced by corticosterone in hippocampal neural progenitors. Our study uncovers a crucial role for miR-17-92 in adult neural progenitors through regulation of neurogenesis and anxiety- and depression-like behaviors.

journal_name

Cell Rep

journal_title

Cell reports

authors

Jin J,Kim SN,Liu X,Zhang H,Zhang C,Seo JS,Kim Y,Sun T

doi

10.1016/j.celrep.2016.06.101

subject

Has Abstract

pub_date

2016-08-09 00:00:00

pages

1653-1663

issue

6

issn

2211-1247

pii

S2211-1247(16)30870-1

journal_volume

16

pub_type

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