Abstract：
:Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two opposite long noncoding RNAs (lncRNAs), Hotdog and Twin of Hotdog, selectively contacts the expressed Hoxd genes in the framework of a topological domain, coinciding with robust transcription of these genes during cecum budding. Both lncRNAs are specifically transcribed in the cecum, albeit bearing no detectable function in trans. Hedgehogs have kept this regulatory potential despite the absence of the cecum, suggesting that these mechanisms are used in other developmental situations. In this context, we discuss the implementation of a common "budding toolkit" between the cecum and the limbs.
journal_name
Cell Repjournal_title
Cell reportsauthors
Delpretti S,Montavon T,Leleu M,Joye E,Tzika A,Milinkovitch M,Duboule Ddoi
10.1016/j.celrep.2013.09.002subject
Has Abstractpub_date
2013-10-17 00:00:00pages
137-50issue
1issn
2211-1247pii
S2211-1247(13)00500-7journal_volume
5pub_type
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