Abstract：
:The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations of EZH2 and their role in cancer pathogenesis. Here, we show that SET and MYND domain containing 2 (SMYD2) directly methylates EZH2 at lysine 307 (K307) and enhances its stability, which can be relieved by the histone H3K4 demethylase lysine-specific demethylase 1 (LSD1). SMYD2 is critical for EZH2 function in repressing a cohort of genes governing several cancer-associated pathways. In addition, SMYD2 promotes breast cancer cell proliferation, epithelial-mesenchymal transition, and invasion through EZH2 K307 methylation, and it is markedly upregulated in various human cancers. Our data suggest that dynamic crosstalk between SMYD2-mediated EZH2 methylation plays an important role in fine-tuning EZH2 functions in chromatin recruitment and transcriptional repression.
journal_name
Cell Repjournal_title
Cell reportsauthors
Zeng Y,Qiu R,Yang Y,Gao T,Zheng Y,Huang W,Gao J,Zhang K,Liu R,Wang S,Hou Y,Yu W,Leng S,Feng D,Liu W,Zhang X,Wang Ydoi
10.1016/j.celrep.2019.10.004subject
Has Abstractpub_date
2019-11-05 00:00:00pages
1482-1498.e4issue
6issn
2211-1247pii
S2211-1247(19)31297-5journal_volume
29pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Spinal cord longitudinal axons comprise some of the longest axons in our body. However, mechanisms that drive this extra long-distance axonal growth are largely unclear. We found that ascending axons of rapidly adapting (RA) mechanoreceptors closely abut a previously undescribed population of roof plate-derived radial...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.05.025
更新日期：2018-06-05 00:00:00
abstract：:The 40,000 neurons of the medulla, the largest visual processing center of the Drosophila brain, derive from a sheet of neuroepithelial cells. During larval development, a wave of differentiation sweeps across the neuroepithelium, converting neuroepithelial cells into neuroblasts that sequentially express transcriptio...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.047
更新日期：2017-08-08 00:00:00
abstract：:Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos. During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygotic epigenome. Here, we demonstrate that Xenopus laevis Npm post-tran...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.02.038
更新日期：2015-03-17 00:00:00
abstract：:Memories are believed to be stored in distributed neuronal assemblies through activity-induced changes in synaptic and intrinsic properties. However, the specific mechanisms by which different memories become associated or linked remain a mystery. Here, we develop a simplified, biophysically inspired network model tha...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.10.015
更新日期：2016-11-01 00:00:00
abstract：:Kainate receptors (KARs) mediate postsynaptic currents with a key impact on neuronal excitability. However, the molecular determinants controlling KAR postsynaptic localization and stabilization are poorly understood. Here, we exploit optogenetic and single-particle tracking approaches to study the role of KAR conform...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107735
更新日期：2020-06-09 00:00:00
abstract：:Working memory is mediated by the coordinated activation of frontal and parietal cortices occurring in the theta and alpha frequency ranges. Here, we test whether electrically stimulating frontal and parietal regions at the frequency of interaction is effective in modulating working memory. We identify working memory ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.10.072
更新日期：2019-11-26 00:00:00
abstract：:Mitophagy plays an important role in mitochondrial quality control. In yeast, phosphorylation of the mitophagy receptor Atg32 by casein kinase 2 (CK2) upon induction of mitophagy is a prerequisite for interaction of Atg32 with Atg11 (an adaptor protein for selective autophagy) and following delivery of mitochondria to...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.05.064
更新日期：2018-06-19 00:00:00
abstract：:Maintaining genome integrity requires the accurate and complete replication of chromosomal DNA. This is of the utmost importance for embryonic stem cells (ESCs), which differentiate into cells of all lineages, including germ cells. However, endogenous and exogenous factors frequently induce stalling of replication for...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.01.014
更新日期：2014-02-27 00:00:00
abstract：:Learning critically depends on the ability to rapidly form and store non-overlapping representations of the external world. In line with their postulated role in episodic memory, hippocampal place cells can undergo a rapid reorganization of their firing fields upon contextual manipulations. To explore the mechanisms u...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.031
更新日期：2018-04-03 00:00:00
abstract：:The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of these interactions involve recruitment of the cohesin complex to chromatin via CTCF. We find that CTCF also interacts with the centromeric protein CENP-E both in v...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.005
更新日期：2015-09-08 00:00:00
abstract：:Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal transition and cancer metastasis. Mutation of ZEB1 is associated with human diseases and defective brain development. Here we show that downregulation of Zeb1 expression in embryonic cortical neural progenitor cells (NPCs) is nece...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.081
更新日期：2019-05-21 00:00:00
abstract：:Lineage analysis of autoreactive B cells can reveal the origins of autoimmunity. In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether anti-DSG IgG4 B cell...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.07.093
更新日期：2018-08-28 00:00:00
abstract：:Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by spontaneous pain and mechanical hypersensitivity. Although loss of inhibitory tone in the dorsal horn of the spinal cord is a major contributor to neuropathic pain, th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.09.080
更新日期：2015-11-10 00:00:00
abstract：:CRISPR/Cas-based technologies have revolutionized genetic approaches to addressing a wide range of neurobiological questions. The ability of CRISPR/Cas to introduce mutations into target genes allows us to perform in vivo loss-of-function experiments without generating genetically engineered mice. However, the lack of...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.06.038
更新日期：2019-07-09 00:00:00
abstract：:The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was contradicted by the identification of capped transcripts missing portions of their 5' ends and a cytoplasmic complex that can restore the cap on uncapped mRNAs. In this study, we used accumulation of uncapped transcripts in cells inhibited ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.07.011
更新日期：2012-09-27 00:00:00
abstract：:5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be elucidated. Here, we show that chronic restraint stress (CRS) induced depression-l...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.11.061
更新日期：2018-12-11 00:00:00
abstract：:The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor p...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.002
更新日期：2018-02-20 00:00:00
abstract：:A systematic cataloging of genes affected by genomic rearrangement, using multiple patient cohorts and cancer types, can provide insight into cancer-relevant alterations outside of exomes. By integrative analysis of whole-genome sequencing (predominantly low pass) and gene expression data from 1,448 cancers involving ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.025
更新日期：2018-07-10 00:00:00
abstract：:SUMOylation is the covalent conjugation of SUMO polypeptides to cellular target proteins. Psmd1 is a subunit of the proteasomal 19S regulatory particle that acts as a docking site for Adrm1, another proteasome subunit that recruits ubiquitinated substrates for proteolysis. Here, we show that the SUMO deconjugating enz...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.05.009
更新日期：2014-06-26 00:00:00
abstract：:The circadian clock generates biological rhythms of metabolic and physiological processes, including the sleep-wake cycle. We previously identified a missense mutation in the flavin adenine dinucleotide (FAD) binding pocket of CRYPTOCHROME2 (CRY2), a clock protein that causes human advanced sleep phase. This prompted ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.03.041
更新日期：2017-04-11 00:00:00
abstract：:Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS fragility in human cell...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.103
更新日期：2019-04-23 00:00:00
abstract：:Pancreatic β cells secrete insulin by Ca2+-triggered exocytosis. However, there is no apparent secretory site similar to the neuronal active zones, and the cellular and molecular localization mechanism underlying polarized exocytosis remains elusive. Here, we report that ELKS, a vertebrate active zone protein, is used...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.12.106
更新日期：2019-01-29 00:00:00
abstract：:Nutrient transporters can be rapidly removed from the cell surface via substrate-stimulated endocytosis as a way to control nutrient influx, but the molecular underpinnings are not well understood. In this work, we focus on zinc-dependent endocytosis of human ZIP4 (hZIP4), a zinc transporter that is essential for diet...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107582
更新日期：2020-04-28 00:00:00
abstract：:DC-SIGN+ monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial infections and inflammatory diseases, but the factors regulating their differentiation and proinflammatory status remain poorly defined. Here, we identify a microRNA, miR-181a, and a molecular mechanism that simultaneously regulate th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.077
更新日期：2020-03-17 00:00:00
abstract：:The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor formation. Here, we uncover a role for HUWE1 in cell migration and invasion through degrading the RAC activator TIAM1, implying an additional function in malignant progression. In MDCKII cells in response to HGF, HUWE1 catalyzes TIAM...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.12.012
更新日期：2015-01-06 00:00:00
abstract：:PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.03.030
更新日期：2015-04-21 00:00:00
abstract：:In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated at Ser139 to promote DSB repair. Here we show that H2AX is rapidly stabilized in response to DSBs to efficiently generate γH2AX foci. This mechanism operated even in quiescent cells that barely expressed H2AX. H2AX stabilization resulted fr...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.11.054
更新日期：2015-12-29 00:00:00
abstract：:Dietary nutrients interact with gene networks to orchestrate adaptive responses during metabolic stress. Here, we identify Baf60a as a diet-sensitive subunit of the SWI/SNF chromatin-remodeling complexes in the mouse liver that links the consumption of fat- and cholesterol-rich diet to elevated plasma cholesterol leve...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.10.033
更新日期：2015-11-24 00:00:00
abstract：:This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.063
更新日期：2018-04-03 00:00:00
abstract：:Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2+ cells at the apex of tumor progression and relapse. To test whether this mechanism is rooted in a normal developmental process, we studie...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.03.075
更新日期：2020-04-14 00:00:00
