当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

Abstract：

:This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations, and/or aberrant methylation of genes and microRNAs, which are correlated with the expression of multi-gene programs linked to squamous cell stemness, epithelial-to-mesenchymal differentiation, growth, genomic integrity, oxidative damage, death, and inflammation. Low-CNA SCCs tended to be HPV(+) and display hypermethylation with repression of TET1 demethylase and FANCF, previously linked to predisposition to SCC, or harbor mutations affecting CASP8, RAS-MAPK pathways, chromatin modifiers, and immunoregulatory molecules. We uncovered hypomethylation of the alternative promoter that drives expression of the ΔNp63 oncogene and embedded miR944. Co-expression of immune checkpoint, T-regulatory, and Myeloid suppressor cells signatures may explain reduced efficacy of immune therapy. These findings support possibilities for molecular classification and therapeutic approaches.

journal_name

Cell Rep

journal_title

Cell reports

authors

Campbell JD,Yau C,Bowlby R,Liu Y,Brennan K,Fan H,Taylor AM,Wang C,Walter V,Akbani R,Byers LA,Creighton CJ,Coarfa C,Shih J,Cherniack AD,Gevaert O,Prunello M,Shen H,Anur P,Chen J,Cheng H,Hayes DN,Bullman S,Ped

doi

10.1016/j.celrep.2018.03.063

subject

Has Abstract

pub_date

2018-04-03 00:00:00

pages

194-212.e6

issue

1

issn

2211-1247

pii

S2211-1247(18)30424-8

journal_volume

23

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3' UTR Elements.

    abstract：:CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which are enriched for 3' UTRs in synaptic protein-coding genes. ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108531

    authors： Rieger MA,King DM,Crosby H,Liu Y,Cohen BA,Dougherty JD

    更新日期：2020-12-22 00:00:00

  • Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.

    abstract：:Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and dise...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.05.050

    authors： Marcon E,Ni Z,Pu S,Turinsky AL,Trimble SS,Olsen JB,Silverman-Gavrila R,Silverman-Gavrila L,Phanse S,Guo H,Zhong G,Guo X,Young P,Bailey S,Roudeva D,Zhao D,Hewel J,Li J,Gräslund S,Paduch M,Kossiakoff AA,Lupien M,

    更新日期：2014-07-10 00:00:00

  • Systems-level response to point mutations in a core metabolic enzyme modulates genotype-phenotype relationship.

    abstract：:Linking the molecular effects of mutations to fitness is central to understanding evolutionary dynamics. Here, we establish a quantitative relation between the global effect of mutations on the E. coli proteome and bacterial fitness. We created E. coli strains with specific destabilizing mutations in the chromosomal f...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.03.051

    authors： Bershtein S,Choi JM,Bhattacharyya S,Budnik B,Shakhnovich E

    更新日期：2015-04-28 00:00:00

  • Autoreactive IgG and IgA B Cells Evolve through Distinct Subclass Switch Pathways in the Autoimmune Disease Pemphigus Vulgaris.

    abstract：:Lineage analysis of autoreactive B cells can reveal the origins of autoimmunity. In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether anti-DSG IgG4 B cell...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.093

    authors： Ellebrecht CT,Mukherjee EM,Zheng Q,Choi EJ,Reddy SG,Mao X,Payne AS

    更新日期：2018-08-28 00:00:00

  • Pancreatic Islet Blood Flow Dynamics in Primates.

    abstract：:Blood flow regulation in pancreatic islets is critical for function but poorly understood. Here, we establish an in vivo imaging platform in a non-human primate where islets transplanted autologously into the anterior chamber of the eye are monitored non-invasively and longitudinally at single-cell resolution. Engraft...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.07.039

    authors： Diez JA,Arrojo E Drigo R,Zheng X,Stelmashenko OV,Chua M,Rodriguez-Diaz R,Fukuda M,Köhler M,Leibiger I,Tun SBB,Ali Y,Augustine GJ,Barathi VA,Berggren PO

    更新日期：2017-08-08 00:00:00

  • Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1.

    abstract：:Cell growth is coupled to cell-cycle progression in mitotically proliferating mammalian cells, but the underlying molecular mechanisms are not well understood. CyclinD-Cdk4/6 is known to phosphorylate RB to promote S-phase entry, but recent work suggests they have additional functions. We show here that CyclinD-Cdk4/6...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.03.068

    authors： Romero-Pozuelo J,Figlia G,Kaya O,Martin-Villalba A,Teleman AA

    更新日期：2020-04-14 00:00:00

  • Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure.

    abstract：:Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the oncogenic potential of these cells have been described. However, the universal applicability of these tumor-suppressive barriers remains contro...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.04.006

    authors： Gerlach SU,Eichenlaub T,Herranz H

    更新日期：2018-05-01 00:00:00

  • A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.

    abstract：:A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs1696...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.07.020

    authors： Lewis A,Freeman-Mills L,de la Calle-Mustienes E,Giráldez-Pérez RM,Davis H,Jaeger E,Becker M,Hubner NC,Nguyen LN,Zeron-Medina J,Bond G,Stunnenberg HG,Carvajal JJ,Gomez-Skarmeta JL,Leedham S,Tomlinson I

    更新日期：2014-08-21 00:00:00

  • FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function.

    abstract：:53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficient cancers. In this study, we show that FOXK1 associates with 53BP1 and regula...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108018

    authors： Tang M,Feng X,Pei G,Srivastava M,Wang C,Chen Z,Li S,Zhang H,Zhao Z,Li X,Chen J

    更新日期：2020-08-11 00:00:00

  • The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1.

    abstract：:How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.04.078

    authors： Camacho J,Truong L,Kurt Z,Chen YW,Morselli M,Gutierrez G,Pellegrini M,Yang X,Allard P

    更新日期：2018-05-22 00:00:00

  • Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly.

    abstract：:Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instability in both mammals a...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.01.054

    authors： Bianchi FT,Tocco C,Pallavicini G,Liu Y,Vernì F,Merigliano C,Bonaccorsi S,El-Assawy N,Priano L,Gai M,Berto GE,Chiotto AM,Sgrò F,Caramello A,Tasca L,Ala U,Neri F,Oliviero S,Mauro A,Geley S,Gatti M,Di Cunto F

    更新日期：2017-02-14 00:00:00

  • Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity.

    abstract：:Neurons face the challenge of maintaining cellular homeostasis through lysosomal degradation. While enzymatically active degradative lysosomes are enriched in the soma, their axonal trafficking and positioning and impact on axonal physiology remain elusive. Here, we characterized axon-targeted delivery of degradative ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.06.013

    authors： Farfel-Becker T,Roney JC,Cheng XT,Li S,Cuddy SR,Sheng ZH

    更新日期：2019-07-02 00:00:00

  • Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.

    abstract：:The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2 are recruited to target sites in vertebrate cells are not well understood. Building on recent studies that determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that, in methylation-deficient emb...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.04.012

    authors： Cooper S,Dienstbier M,Hassan R,Schermelleh L,Sharif J,Blackledge NP,De Marco V,Elderkin S,Koseki H,Klose R,Heger A,Brockdorff N

    更新日期：2014-06-12 00:00:00

  • Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates.

    abstract：:Generating mammalian cells with desired mitochondrial DNA (mtDNA) sequences is enabling for studies of mitochondria, disease modeling, and potential regenerative therapies. MitoPunch, a high-throughput mitochondrial transfer device, produces cells with specific mtDNA-nuclear DNA (nDNA) combinations by transferring iso...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108562

    authors： Patananan AN,Sercel AJ,Wu TH,Ahsan FM,Torres A Jr,Kennedy SAL,Vandiver A,Collier AJ,Mehrabi A,Van Lew J,Zakin L,Rodriguez N,Sixto M,Tadros W,Lazar A,Sieling PA,Nguyen TL,Dawson ER,Braas D,Golovato J,Cisneros L,V

    更新日期：2020-12-29 00:00:00

  • Exosome secretion is enhanced by invadopodia and drives invasive behavior.

    abstract：:Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs) occurs across a broad set of systems and is reported to be upregulated in cancer, where it promotes aggressive behavior. However, regulatory control of exosome secretion is poorly understood. Using cancer cells, we identified specialized...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.10.050

    authors： Hoshino D,Kirkbride KC,Costello K,Clark ES,Sinha S,Grega-Larson N,Tyska MJ,Weaver AM

    更新日期：2013-12-12 00:00:00

  • Activity in Primary Motor Cortex Related to Visual Feedback.

    abstract：:Neural modulation in primate motor cortex exhibits complex patterns. We found that modulation during reaching could be separated into discrete temporal epochs. To determine if these epochs are driven by behavioral events, monkeys performed variations of a center-out reaching task. Monkeys viewed a computer cursor matc...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.069

    authors： Suway SB,Schwartz AB

    更新日期：2019-12-17 00:00:00

  • Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma.

    abstract：:Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual ependymomas is unknown. We perform multiplatform molecular profiling of 6 spatially distinct samples from an ependymoma with C11orf95-RELA fusion. DNA methylation and RNA sequencing distinguish clusters of samples accord...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.01.018

    authors： Liu SJ,Magill ST,Vasudevan HN,Hilz S,Villanueva-Meyer JE,Lastella S,Daggubati V,Spatz J,Choudhury A,Orr BA,Demaree B,Seo K,Ferris SP,Abate AR,Oberheim Bush NA,Bollen AW,McDermott MW,Costello JF,Raleigh DR

    更新日期：2020-02-04 00:00:00

  • DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.

    abstract：:Embryonic stem cells (ESCs) exhibit high levels of ribosomal RNA (rRNA) transcription and ribosome biogenesis. Here, we reveal an unexpected role for an essential DEAD-box helicase, DDX18, in antagonizing the polycomb repressive complex 2 (PRC2) to prevent deposition of the repressive H3K27me3 mark onto rDNA in plurip...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.12.021

    authors： Zhang H,Wu Z,Lu JY,Huang B,Zhou H,Xie W,Wang J,Shen X

    更新日期：2020-01-07 00:00:00

  • CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites.

    abstract：:The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of these interactions involve recruitment of the cohesin complex to chromatin via CTCF. We find that CTCF also interacts with the centromeric protein CENP-E both in v...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.08.005

    authors： Xiao T,Wongtrakoongate P,Trainor C,Felsenfeld G

    更新日期：2015-09-08 00:00:00

  • Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.

    abstract：:Successful anti-viral response requires the sustained activation and expansion of CD8+ T cells for periods that far exceed the time limit of physical T cell interaction with antigen-presenting cells (APCs). The expanding CD8+ T cell pool generates the effector and memory cell populations that provide viral clearance a...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.06.075

    authors： Dimitriou ID,Lee K,Akpan I,Lind EF,Barr VA,Ohashi PS,Samelson LE,Rottapel R

    更新日期：2018-07-31 00:00:00

  • The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge.

    abstract：:The macrophage NLRC4 inflammasome drives potent innate immune responses against Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (e.g., interleukin-1β [IL-1β]) and pyroptotic cell death. However, the potential contribution of other cell types to inflammasome-mediated host defense against...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.028

    authors： Chen KW,Groß CJ,Sotomayor FV,Stacey KJ,Tschopp J,Sweet MJ,Schroder K

    更新日期：2014-07-24 00:00:00

  • Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice.

    abstract：:Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the s...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.087

    authors： Munanairi A,Liu XY,Barry DM,Yang Q,Yin JB,Jin H,Li H,Meng QT,Peng JH,Wu ZY,Yin J,Zhou XY,Wan L,Mo P,Kim S,Huo FQ,Jeffry J,Li YQ,Bardoni R,Bruchas MR,Chen ZF

    更新日期：2018-04-17 00:00:00

  • Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.

    abstract：:The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close prox...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.007

    authors： De La Fuente AG,Lange S,Silva ME,Gonzalez GA,Tempfer H,van Wijngaarden P,Zhao C,Di Canio L,Trost A,Bieler L,Zaunmair P,Rotheneichner P,O'Sullivan A,Couillard-Despres S,Errea O,Mäe MA,Andrae J,He L,Keller A,Bátiz LF

    更新日期：2017-08-22 00:00:00

  • Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.

    abstract：:The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can substitute qualitatively for Nanog function in ESCs. Whether this functional substitution extend...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.12.060

    authors： Zhang M,Leitch HG,Tang WWC,Festuccia N,Hall-Ponsele E,Nichols J,Surani MA,Smith A,Chambers I

    更新日期：2018-01-09 00:00:00

  • Structural and Molecular Basis for Katanin-Mediated Severing of Glutamylated Microtubules.

    abstract：:Katanin was the first microtubule (MT)-severing enzyme discovered, but how katanin executes MT severing remains poorly understood. Here, we report X-ray crystal structures of the apo and ATPγS-bound states of the catalytic AAA domain of human katanin p60 at 3.0 and 2.9 Å resolution, respectively. Comparison of the two...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.01.020

    authors： Shin SC,Im SK,Jang EH,Jin KS,Hur EM,Kim EE

    更新日期：2019-01-29 00:00:00

  • A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis.

    abstract：:The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and anti-tumor effects of the Hipp...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108284

    authors： He L,Yuan L,Yu W,Sun Y,Jiang D,Wang X,Feng X,Wang Z,Xu J,Yang R,Zhang W,Feng H,Chen HZ,Zeng YA,Hui L,Wu Q,Zhang Y,Zhang L

    更新日期：2020-10-20 00:00:00

  • Spontaneous Vesicle Fusion Is Differentially Regulated at Cholinergic and GABAergic Synapses.

    abstract：:The locomotion of C. elegans is balanced by excitatory and inhibitory neurotransmitter release at neuromuscular junctions. However, the molecular mechanisms that maintain the balance of synaptic transmission remain enigmatic. Here, we investigated the function of voltage-gated Ca2+ channels in triggering spontaneous r...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.023

    authors： Liu H,Li L,Wang W,Gong J,Yang X,Hu Z

    更新日期：2018-02-27 00:00:00

  • Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene.

    abstract：:Many animals fight for dominance between conspecifics. Because winners could obtain more resources than losers, fighting outcomes are important for the animal's survival, especially in a situation with insufficient resources, such as hunger. However, it remains unclear whether and how hunger affects fighting outcomes....

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107790

    authors： Nakajo H,Chou MY,Kinoshita M,Appelbaum L,Shimazaki H,Tsuboi T,Okamoto H

    更新日期：2020-06-23 00:00:00

  • Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles.

    abstract：:Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining a genetic strategy with longitudinal live imaging, we find that indiv...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.01.089

    authors： Gao X,Zhang Z,Mashimo T,Shen B,Nyagilo J,Wang H,Wang Y,Liu Z,Mulgaonkar A,Hu XL,Piccirillo SGM,Eskiocak U,Davé DP,Qin S,Yang Y,Sun X,Fu YX,Zong H,Sun W,Bachoo RM,Ge WP

    更新日期：2020-02-25 00:00:00

  • The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation.

    abstract：:Activation of CaV2.1 voltage-gated calcium channels is facilitated by preceding calcium entry. Such self-modulatory facilitation is thought to contribute to synaptic facilitation. Using knockin mice with mutated CaV2.1 channels that do not facilitate (Ca IM-AA mice), we surprisingly found that, under conditions of phy...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.01.114

    authors： Weyrer C,Turecek J,Niday Z,Liu PW,Nanou E,Catterall WA,Bean BP,Regehr WG

    更新日期：2019-02-26 00:00:00